Vancomycin and Staphylococcus aureus capsule gene: Analysis Of Capsule Gene Expression In Clinical Strains of Staphylococcus aureus Exposed To Vancomycin

OTOKUNEFOR, KOME; UPTON (PhD), MAT

ISBN 10: 3838383982 / ISBN 13: 9783838383989

Edité par LAP LAMBERT Academic Publishing, 2010

In English. N° de réf. du vendeur ria9783838383989_new

Synopsis :

With more than 10 years following the emergence of low level vancomycin resistance in Staphylococcus aureus isolates, the molecular mechanism responsible for this resistance is not fully understood. This piece of work which explores the effect of varying concentrations of vancomycin on the capsule gene expression points at a role for the S. aureus capsule in resistance with an important link noted between increased capsule gene expression and survival at lethal vancomycin concentrations. It thereby provides the scientific community with an insight into the molecular mechanisms associated with low level vancomycin resistance and raises the effect of strain genetic background on low level vancomycin resistance and treatment failure. The study also offers an in-depth exploration of relevant literature and detailed description of methods.

Présentation de l'éditeur: With more than 10 years following the emergence of low level vancomycin resistance in Staphylococcus aureus isolates, the molecular mechanism responsible for this resistance is not fully understood. This piece of work which explores the effect of varying concentrations of vancomycin on the capsule gene expression points at a role for the S. aureus capsule in resistance with an important link noted between increased capsule gene expression and survival at lethal vancomycin concentrations. It thereby provides the scientific community with an insight into the molecular mechanisms associated with low level vancomycin resistance and raises the effect of strain genetic background on low level vancomycin resistance and treatment failure. The study also offers an in-depth exploration of relevant literature and detailed description of methods.

Détails bibliographiques

Titre : Vancomycin and Staphylococcus aureus capsule...
Éditeur : LAP LAMBERT Academic Publishing
Date d'édition : 2010
Reliure : Couverture souple
Etat : New