Vol 508 No.7495, April 2014, Vital Connections. Cet article n’est pas disponible.Vol 508 No.7495, April 2014, Vital Connections

Climate policy: Streamline IPCC reports As the Intergovernmental Panel on Climate Change asks how its assessment process should evolve, Dave Griggs argues for decadal updates and eased workloads. Global warming: Improve economic models of climate change Costs of carbon emissions are being underestimated, but current estimates are still valuable for setting mitigation policy, say Richard L. Revesz and colleagues. Biotechnology: Recombinant gold Nathaniel Comfort applauds a nuanced history of genetic engineering's early years. Review of Gene Jockeys: Life Science and the Rise of Biotech Enterprise Nicolas Rasmussen Ecology: Wilson in Africa Stuart Pimm enjoys a fellow naturalist's first visit to sub-Saharan Africa, and the global lessons drawn from it. Review of A Window on Eternity: A Biologist's Walk Through Gorongosa National Park Edward O. Wilson New in paperback Highlights of this season's releases Climate Economics: A strained relationship Scott Barrett examines a study probing the nexus between climate change and energy. Review of Planetary Economics: Energy, Climate Change and the Three Domains of Sustainable Development Michael Grubb, Jean-Charles Hourcade & Karsten Neuhoff Medicine: Outside the fold Giovanna Mallucci assesses the autobiography of Stanley Prusiner, the discoverer of prions. Review of Madness and Memory: The Discovery of Prions ? A New Biological Principle of Disease Stanley B. Prusiner Drugs: Gut response Maryn McKenna finds much to digest in a warning about the demise of our bodily bacteria. Review of Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues Martin J. Blaser Education: Digital lessons learned Robert Lue enjoys a deft study of online pedagogy. Review of The War on Learning: Gaining Ground in the Digital University Elizabeth Losh Energy: The new oil era Chris Nelder relishes a lively history of fracking that delves into the complexities. Review of The Boom: How Fracking Ignited the American Energy Revolution and Changed the World Russell Gold Solar system: Cracking up on asteroids Heather A. Viles See also Letter by Delbo et al. Cancer: Damage prevention targeted Dan Dominissini & Chuan He See also Article by Gad et al. See also Article by Huber et al. Biogeoscience: Africa's greenhouse-gas budget is in the red Cheikh Mbow Metabolism: Targeting a fat-accumulation gene Charles Brenner See also Letter by Kraus et al. Quantum physics: A strong hybrid couple Luming Duan See also Letter by Reiserer et al. See also Letter by Tiecke et al. Structural biology: The purple heart of photosynthesis Richard J. Cogdell & Aleksander W. Roszak See also Article by Niwa et al. Articles Top Transcriptional landscape of the prenatal human brain Jeremy A. Miller, Song-Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng + et al. A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders. A mesoscale connectome of the mouse brain Seung Wook Oh, Julie A. Harris, Lydia Ng, Brent Winslow, Nicholas Cain + et al. In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A. Jacques + et al. In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 ? in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells.…