Nasal and Pulmonary Drug Delivery System: Advancement in Naso-pulmonary Drug Delivery System - Couverture souple

Satapara, Rahul; Satapara, Vijay; Patel, L.D.

 
9783659170607: Nasal and Pulmonary Drug Delivery System: Advancement in Naso-pulmonary Drug Delivery System
Couverture souple
ISBN 10 : 3659170607 ISBN 13 : 9783659170607
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The widespread interest in intranasal route for therapeutic purposes other than the topically nasal drug delivery arises from the particular anatomical, physiological and histological characteristics of the nasal cavity, which provides potential for rapid systemic drug absorption and quick onset of action. In addition, intranasal absorption avoids the gastrointestinal and hepatic presystemic metabolism, enhancing drug bioavailability in comparison with that obtained after gastrointestinal absorption. Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs could provide a large absorptive surface area (up to 100 m2 ) but extremely thin (0.1 μm – 0.2 μm) absorptive mucosal membrane and good blood supply. However, recent advances show great promise, but pulmonary delivery of peptides and proteins is complicated by the complexity of the anatomic structure of the human respiratory system and the effect of disposition exerted by the respiration process.

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Présentation de l'éditeur

The widespread interest in intranasal route for therapeutic purposes other than the topically nasal drug delivery arises from the particular anatomical, physiological and histological characteristics of the nasal cavity, which provides potential for rapid systemic drug absorption and quick onset of action. In addition, intranasal absorption avoids the gastrointestinal and hepatic presystemic metabolism, enhancing drug bioavailability in comparison with that obtained after gastrointestinal absorption. Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs could provide a large absorptive surface area (up to 100 m2 ) but extremely thin (0.1 μm – 0.2 μm) absorptive mucosal membrane and good blood supply. However, recent advances show great promise, but pulmonary delivery of peptides and proteins is complicated by the complexity of the anatomic structure of the human respiratory system and the effect of disposition exerted by the respiration process.

Biographie de l'auteur

Mr.Rahul G. Satapara is doing M.pharma. in Pharmaceutics from Gujarat Technological University. He also doing Post graduate diploma in patent lawfrom Nalsar university,Hyderabad.He has completed D.Pharma. & B.Pharma. from Saurashtra University.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659170607
ISBN 13 
9783659170607
Reliure
Broché
Nombre de pages
76
Coordonnées du fabricant
non disponible
Personne responsable
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