Theoretical Aspects of Anticancer Drugs: Development of Structure-Activity Relationships for Drug Design - Couverture souple

Sarmah, Pubalee; C. Deka, Ramesh

 
9783844382808: Theoretical Aspects of Anticancer Drugs: Development of Structure-Activity Relationships for Drug Design
Couverture souple
ISBN 10 : 3844382801 ISBN 13 : 9783844382808
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Cancer has a high mortality rate worldwide till date. Several approaches viz., surgery, radiation therapyand chemotherapy have been employed to treat cancer. Since new anticancer drugs have been discovered, thecuring rate of chemotherapy has improved over thelast decades. Designing and development of new drugsfrom the laboratory bench to the clinic is a complex,expensive, and very time consuming task. In thiscontext rational computer-aided drug design with thehelp of available data, especially the insilico-based quantitative structure-activityrelationship (QSAR) techniques have emerged as apromising alternative tool toward the effectivescreening of potential drugs. In this book, theauthors present the comprehensive structure-activitymodelling of some anticancer drugs using DensityFunctional Theory (DFT) based reactivity descriptors. Further, the theoretical studies of platinumdrug-DNA adduct provide the evidence ofintermolecular proton transfer between the base pairswhich explains the damage of DNA when the drugmolecule binds with it. This book will be helpfulfor researchers working in the field of medicinalchemistry and drug design.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Cancer has a high mortality rate worldwide till date. Several approaches viz., surgery, radiation therapyand chemotherapy have been employed to treat cancer. Since new anticancer drugs have been discovered, thecuring rate of chemotherapy has improved over thelast decades. Designing and development of new drugsfrom the laboratory bench to the clinic is a complex,expensive, and very time consuming task. In thiscontext rational computer-aided drug design with thehelp of available data, especially the insilico-based quantitative structure-activityrelationship (QSAR) techniques have emerged as apromising alternative tool toward the effectivescreening of potential drugs. In this book, theauthors present the comprehensive structure-activitymodelling of some anticancer drugs using DensityFunctional Theory (DFT) based reactivity descriptors. Further, the theoretical studies of platinumdrug-DNA adduct provide the evidence ofintermolecular proton transfer between the base pairswhich explains the damage of DNA when the drugmolecule binds with it. This book will be helpfulfor researchers working in the field of medicinalchemistry and drug design.

Biographie de l'auteur

Dr. Sarmah, (Ph. D. Tezpur University, India) is an AssistantProfessor of Dept. of Chemistry, Royal School of Engineering &Tech., India. Prof. Deka, Ph. D. from NCL Pune, did hispost-doctoral research at Tokyo University before joining TU in2001. He is also an AvH fellow. His research interests aremolecular modelling and catalysis.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844382801
ISBN 13 
9783844382808
Reliure
Broché
Nombre de pages
192
Coordonnées du fabricant
non disponible
Personne responsable
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