Articles liés à REGULATORY T CELLS AND INTERLEUKIN-10: Role in Pulmonary...

REGULATORY T CELLS AND INTERLEUKIN-10: Role in Pulmonary Tuberculosis - Couverture souple

Nasser, Marwa; Nasr, Rasha; Draz, Nehal

 
9783845404370: REGULATORY T CELLS AND INTERLEUKIN-10: Role in Pulmonary Tuberculosis
Couverture souple
ISBN 10 : 384540437X ISBN 13 : 9783845404370
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Mycobacterium tuberculosis infects one-third of the world's population and causes almost 2 million deaths per year. In spite of intense research on the immune response elicited during tuberculosis, the mechanisms involved in the development of active disease remain obscure. There is growing evidence that regulatory T cells may play an important role in the regulation of host immune responses against M. tuberculosis. In some circumstances, the regulation exerted by regulatory T cells is excessive and prevents the establishment of protective immune responses, whereas in other circumstances, this control is not sufficient to prevent immunopathology. IL-10 has been described as a T helper 2 cytokine with immunosuppressive properties. In addition, IL-10 secretion has been reported as one of the mechanisms by which regulatory T cells may exert their suppressive function. This study, therefore, was conducted to determine CD4+CD25+ regulatory T cells % and the levels of IL-10 mRNA expression in peripheral blood of patients with active pulmonary tuberculosis. This should help to assess a possible role of these cells in the immunopathogenesis of TB, and should be especially useful to researc

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Présentation de l'éditeur

Mycobacterium tuberculosis infects one-third of the world's population and causes almost 2 million deaths per year. In spite of intense research on the immune response elicited during tuberculosis, the mechanisms involved in the development of active disease remain obscure. There is growing evidence that regulatory T cells may play an important role in the regulation of host immune responses against M. tuberculosis. In some circumstances, the regulation exerted by regulatory T cells is excessive and prevents the establishment of protective immune responses, whereas in other circumstances, this control is not sufficient to prevent immunopathology. IL-10 has been described as a T helper 2 cytokine with immunosuppressive properties. In addition, IL-10 secretion has been reported as one of the mechanisms by which regulatory T cells may exert their suppressive function. This study, therefore, was conducted to determine CD4+CD25+ regulatory T cells % and the levels of IL-10 mRNA expression in peripheral blood of patients with active pulmonary tuberculosis. This should help to assess a possible role of these cells in the immunopathogenesis of TB, and should be especially useful to researc

Biographie de l'auteur

Marwa Shabban El Sayed Ibrahim Nasser,M.Sc.,Ph.D.: Medical Microbiology and Immunology Faculty of Medicine, Ain Shams University.Lecturer of Medical Microbiology and Immunology,Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
384540437X
ISBN 13 
9783845404370
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
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