Articles liés à Genotoxicity of fluoride: Modulation of endogenous...

Genotoxicity of fluoride: Modulation of endogenous glutathione level: An in vivo approach with Swiss-albino mice to characterize F genotoxicity - Couverture souple

Podder, Santosh; Chattopadhyay, Ansuman; Bhattacharya, Shelley

 
9783847340669: Genotoxicity of fluoride: Modulation of endogenous glutathione level: An in vivo approach with Swiss-albino mice to characterize F genotoxicity
Couverture souple
ISBN 10 : 3847340662 ISBN 13 : 9783847340669
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Fluoride (F) toxicity has become a global problem today and needs great concern.F contaminated drinking water could be injurious to bone marrow cells (BMCs) evidenced by chromosomal aberrations (CAs),reduced rate of cell division and induction of apoptosis.As little as 3.4 mg F ion/L in the drinking water F found to be genotoxic,whereas higher concentrations seemed to be less toxic.It results depletion of GSH level and increase in GST activity,MDA production as well as expression of Hsp 70.The tissue-specific pattern of Hsp synthesis may provide a useful toxicological signature to characterize F toxicity.Depletion of endogenous GSH by BSO significantly enhanced the frequency of aberrations.NAC pre-treatment not only led to significant increase in GSH level but also significantly decreased the NaF induced CAs.These indicate the involvement of endogenous GSH in determining F-induced genotoxicity in mouse BMCs.Supply of safe water may be a simpler way to tackle the F-toxicity in large F-endemic population.This book may draw a general concern on the safety level of F contamination and help to better understand the mechanism of action of its genotoxicity and concomitant GSH metabolism.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Fluoride (F) toxicity has become a global problem today and needs great concern.F contaminated drinking water could be injurious to bone marrow cells (BMCs) evidenced by chromosomal aberrations (CAs),reduced rate of cell division and induction of apoptosis.As little as 3.4 mg F ion/L in the drinking water F found to be genotoxic,whereas higher concentrations seemed to be less toxic.It results depletion of GSH level and increase in GST activity,MDA production as well as expression of Hsp 70.The tissue-specific pattern of Hsp synthesis may provide a useful toxicological signature to characterize F toxicity.Depletion of endogenous GSH by BSO significantly enhanced the frequency of aberrations.NAC pre-treatment not only led to significant increase in GSH level but also significantly decreased the NaF induced CAs.These indicate the involvement of endogenous GSH in determining F-induced genotoxicity in mouse BMCs.Supply of safe water may be a simpler way to tackle the F-toxicity in large F-endemic population.This book may draw a general concern on the safety level of F contamination and help to better understand the mechanism of action of its genotoxicity and concomitant GSH metabolism.

Biographie de l'auteur

Dr.Podder;M.Sc. from University of Burdwan and Ph.D from Visva Bharati University.Presently doing his postdoctoral research in the North Eastern Hill University,India.Dr. Chattopadhyay,Associate Professor in the department of Zoology, Visva Bharati University,India.Dr.Bhattacharya is known for her notable contribution in environmental toxicology.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3847340662
ISBN 13 
9783847340669
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
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