ISBN: 9783847340669 - genotoxicity of fluoride: modulation of endogenous glutathione level: an in vivo approach with swiss-albino mice to characterize f genotoxicity (6 résultats)

Taschenbuch. Etat : Neu. Genotoxicity of fluoride: Modulation of endogenous glutathione level | An in vivo approach with Swiss-albino mice to characterize F genotoxicity | Santosh Podder (u. a.) | Taschenbuch | 120 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783847340669 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.…

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fluoride (F) toxicity has become a global problem today and needs great concern.F contaminated drinking water could be injurious to bone marrow cells (BMCs) evidenced by chromosomal aberrations (CAs),reduced rate of cell division and induction of apoptosis.As little as 3.4 mg F ion/L in the drinking water F found to be genotoxic,whereas higher concentrations seemed to be less toxic.It results depletion of GSH level and increase in GST activity,MDA production as well as expression of Hsp 70.The tissue-specific pattern of Hsp synthesis may provide a useful toxicological signature to characterize F toxicity.Depletion of endogenous GSH by BSO significantly enhanced the frequency of aberrations.NAC pre-treatment not only led to significant increase in GSH level but also significantly decreased the NaF induced CAs.These indicate the involvement of endogenous GSH in determining F-induced genotoxicity in mouse BMCs.Supply of safe water may be a simpler way to tackle the F-toxicity in large F-endemic population.This book may draw a general concern on the safety level of F contamination and help to better understand the mechanism of action of its genotoxicity and concomitant GSH metabolism. 120 pp. Englisch.…

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Fluoride (F) toxicity has become a global problem today and needs great concern.F contaminated drinking water could be injurious to bone marrow cells (BMCs) evidenced by chromosomal aberrations (CAs),reduced rate of cell division and induction of apoptosis.As little as 3.4 mg F ion/L in the drinking water F found to be genotoxic,whereas higher concentrations seemed to be less toxic.It results depletion of GSH level and increase in GST activity,MDA production as well as expression of Hsp 70.The tissue-specific pattern of Hsp synthesis may provide a useful toxicological signature to characterize F toxicity.Depletion of endogenous GSH by BSO significantly enhanced the frequency of aberrations.NAC pre-treatment not only led to significant increase in GSH level but also significantly decreased the NaF induced CAs.These indicate the involvement of endogenous GSH in determining F-induced genotoxicity in mouse BMCs.Supply of safe water may be a simpler way to tackle the F-toxicity in large F-endemic population.This book may draw a general concern on the safety level of F contamination and help to better understand the mechanism of action of its genotoxicity and concomitant GSH metabolism.…

Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Podder SantoshDr.PodderM.Sc. from University of Burdwan and Ph.D from Visva Bharati University.Presently doing his postdoctoral research in the North Eastern Hill University,India.Dr. Chattopadhyay,Associate Professor in the departm.…

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Fluoride (F) toxicity has become a global problem today and needs great concern.F contaminated drinking water could be injurious to bone marrow cells (BMCs) evidenced by chromosomal aberrations (CAs),reduced rate of cell division and induction of apoptosis.As little as 3.4 mg F ion/L in the drinking water F found to be genotoxic,whereas higher concentrations seemed to be less toxic.It results depletion of GSH level and increase in GST activity,MDA production as well as expression of Hsp 70.The tissue-specific pattern of Hsp synthesis may provide a useful toxicological signature to characterize F toxicity.Depletion of endogenous GSH by BSO significantly enhanced the frequency of aberrations.NAC pre-treatment not only led to significant increase in GSH level but also significantly decreased the NaF induced CAs.These indicate the involvement of endogenous GSH in determining F-induced genotoxicity in mouse BMCs.Supply of safe water may be a simpler way to tackle the F-toxicity in large F-endemic population.This book may draw a general concern on the safety level of F contamination and help to better understand the mechanism of action of its genotoxicity and concomitant GSH metabolism.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch.…