Development and Evaluation of Poorly Soluble Rilpivirine by Snedds: Self Nanoemulsifying Drug Delivery System - Couverture souple

Sandhya, Pamu ; Kumar, V. Vijay ; Bhikshapathi, D. V. R. N.

9786202667678: Development and Evaluation of Poorly Soluble Rilpivirine by Snedds: Self Nanoemulsifying Drug Delivery System

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ISBN 10 : 6202667672 ISBN 13 : 9786202667678

Editeur : LAP LAMBERT Academic Publishing, 2020

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2020
Langue: anglais
ISBN 10: 6202667672
ISBN 13: 9786202667678
Reliure: Broch�
Nombre de pages: 100
Coordonn�es du fabricant: non disponible
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Development and Evaluation of Poorly Soluble Rilpivirine by Snedds

Pamu Sandhya

Edit� par LAP LAMBERT Academic Publishing Okt 2020, 2020

ISBN 10 : 6202667672 ISBN 13 : 9786202667678

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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this work a SNEDDS formulation of a poorly water-soluble drug, Rilpivirine was developed by using different polymers. The solubility study was conducted to find out the suitable oil, surfactant and co-surfactant for Rilpivirine and was shown good solubility in oil like Captex 355, surfactant Kolliphor RH 40 and co-surfactant Propylene glycol. The drug content of all the formulations was performed. Maximum drug content was found in the formulation F5. The in vitro dissolution studies were performed for all the fifteen SNEDDS formulations. The release from liquid SNEDDS formulation F5 was faster than SNEDDS formulations F1 toF15 indicating the influence of droplet size on the rate of drug dissolution. On the basis of visual observation test and faster dissolution rate, formulation F5 was finalized as optimized formulation. The present exploratory work successfully illustrates the potential utility of liquid SNEDDS formulation for the delivery of poor water-soluble compound such as Rilpivirine. The results from this study demonstrate the utility of SNEDDS to enhance solubility and dissolution of Rilpivirine which may result in improved therapeutic performance. 100 pp. Englisch. N� de r�f. du vendeur 9786202667678

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Development and Evaluation of Poorly Soluble Rilpivirine by Snedds : Self Nanoemulsifying Drug Delivery System

Pamu Sandhya

Edit� par LAP LAMBERT Academic Publishing, 2020

ISBN 10 : 6202667672 ISBN 13 : 9786202667678

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - In this work a SNEDDS formulation of a poorly water-soluble drug, Rilpivirine was developed by using different polymers. The solubility study was conducted to find out the suitable oil, surfactant and co-surfactant for Rilpivirine and was shown good solubility in oil like Captex 355, surfactant Kolliphor RH 40 and co-surfactant Propylene glycol. The drug content of all the formulations was performed. Maximum drug content was found in the formulation F5. The in vitro dissolution studies were performed for all the fifteen SNEDDS formulations. The release from liquid SNEDDS formulation F5 was faster than SNEDDS formulations F1 toF15 indicating the influence of droplet size on the rate of drug dissolution. On the basis of visual observation test and faster dissolution rate, formulation F5 was finalized as optimized formulation. The present exploratory work successfully illustrates the potential utility of liquid SNEDDS formulation for the delivery of poor water-soluble compound such as Rilpivirine. The results from this study demonstrate the utility of SNEDDS to enhance solubility and dissolution of Rilpivirine which may result in improved therapeutic performance. N� de r�f. du vendeur 9786202667678

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Development and Evaluation of Poorly Soluble Rilpivirine by Snedds

Pamu Sandhya|V.Vijay Kumar|D.V.R.N. Bhikshapathi

Edit� par LAP LAMBERT Academic Publishing, 2020

ISBN 10 : 6202667672 ISBN 13 : 9786202667678

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sandhya PamuDr. Pamu Sandhya, M. Pharm, Ph.D, Head, Department of Pharmaceutics, at Shadan Women s College of Pharmacy, Hyderabad. She has research experience in NDDS by using QbD. She published 62 research papers in reputed Internat. N� de r�f. du vendeur 493530133

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Development and Evaluation of Poorly Soluble Rilpivirine by Snedds

Pamu Sandhya

Edit� par LAP LAMBERT Academic Publishing Okt 2020, 2020

ISBN 10 : 6202667672 ISBN 13 : 9786202667678

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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this work a SNEDDS formulation of a poorly water-soluble drug, Rilpivirine was developed by using different polymers. The solubility study was conducted to find out the suitable oil, surfactant and co-surfactant for Rilpivirine and was shown good solubility in oil like Captex 355, surfactant Kolliphor RH 40 and co-surfactant Propylene glycol. The drug content of all the formulations was performed. Maximum drug content was found in the formulation F5. The in vitro dissolution studies were performed for all the fifteen SNEDDS formulations. The release from liquid SNEDDS formulation F5 was faster than SNEDDS formulations F1 toF15 indicating the influence of droplet size on the rate of drug dissolution. On the basis of visual observation test and faster dissolution rate, formulation F5 was finalized as optimized formulation. The present exploratory work successfully illustrates the potential utility of liquid SNEDDS formulation for the delivery of poor water-soluble compound such as Rilpivirine. The results from this study demonstrate the utility of SNEDDS to enhance solubility and dissolution of Rilpivirine which may result in improved therapeutic performance.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 100 pp. Englisch. N� de r�f. du vendeur 9786202667678

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