Mechanism of Bone Destruction

Gupta, Shivani; Agarwal, Prerna; Agarwal, Ashutosh

ISBN 10: 620844523X / ISBN 13: 9786208445232

Edité par LAP Lambert Academic Publishing, 2025

A propos de cet article

N° de réf. du vendeur I-9786208445232

Détails bibliographiques

• Titre: Mechanism of Bone Destruction
• Éditeur: LAP Lambert Academic Publishing
• Date de parution: 2025
• Langue: anglais
• ISBN à 10 chiffres: 620844523X
• ISBN à 13 chiffres: 9786208445232
• Reliure: Couverture souple
• État de l'article: New

A propos de ce titre

Synopsis

Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF-α, IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-β, fueling tumor growth and perpetuating degradation. Enzymes like MMPs and cathepsin K degrade bone matrix, while hypoxia and mechanical stress also contribute. Understanding these mechanisms supports treatments like bisphosphonates, RANKL inhibitors (e.g., denosumab), and anti-cytokine therapies, which effectively reduce bone loss.