G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders. Neuromethods, Band 31

Mishra, Ram K., Glen B. Baker and Alan A. Boulton:

ISBN 10: 0896034909 / ISBN 13: 9780896034907

Edité par Humana Press, 1997

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Détails bibliographiques

• Titre: G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders. Neuromethods, Band 31
• Éditeur: Humana Press
• Date de parution: 1997
• Langue: anglais
• ISBN à 10 chiffres: 0896034909
• ISBN à 13 chiffres: 9780896034907
• Reliure: gebundene Ausgabe
• État de l'article: Gut
• Catalogues du vendeur:
  • 90 Varia

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Synopsis

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.