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Taschenbuch. Etat : Neu. Molecular Dynamics Simulations of the Neu Transmembrane Domain | Physical Characterization of Native and Mutated Neu in a Membrane Environment | Bryan van der Ende | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639127621 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. …

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Kartoniert / Broschiert. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: van der Ende BryanDr. Bryan van der Ende studied physics in Canada: in Burnaby,nBritish Columbia and Guelph, Ontario. He is currently anpostdoctoral fellow in Utrecht, The Netherlands.Neu is a membrane-bound protein whose struct.…

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Neu is a membrane-bound protein whose structureincludes a single helix which spans the width of acellular membrane. It is a growth factor receptorwhich dimerizes (forms pairs) when signaling cellgrowth and proliferation. Key mutations at a specificlocation in the transmembrane domain (TMD) of the neuprotein have been demonstrated to result in permanentdimerization of mutated pairs, and are simultaneouslyassociated with the formation of cancerous tumors.The physical effects of these key point mutationsthat lead to such permanent dimerization are notknown. Atomistic molecular dynamics (MD) simulations,whereby Newton's equations of motion are numericallysolved for the atoms in the neu TMD and itssurrounding membrane environment, provide furtherphysical insight into this important problem. Thisbook reviews the MD simulation method as well asprevious work characterizing the neu protein; thebook further examines the results of detailed MDsimulations of native and mutant neu TMDs in hydratedmembrane environments. The reader should have somebasic background in biophysical chemistry, Newtoniandynamics, and statistical mechanics.…