Elsevier bv aug 1998 (5 résultats)

Buch. Etat : Neu. Neuware - The 16th volume in a series on advances in stratification research. Topics addressed include: the changing international context of social stratification; race, immigration and life chances; and the distinctiveness of independent business as a locus of social stratification.…

Buch. Etat : Neu. Neuware - Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts 'translate' into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, 'high risk' or 'preneoplastic' legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.…

Buch. Etat : Neu. Neuware - This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells. In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria. Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by avariety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some.…

Buch. Etat : Neu. Neuware - This fourth volume in the series Organic Synthesis: Theory and Applications is composed of five chapters that span a wide range of disciplines. Alkaloid chemistry, total synthesis, synthetic methodology, carbohydrate technology, and spin-trapping agents are all covered by experts in these fields.The first chapter is one of the finest examples of deductive reasoning in the chemical literature, examining the rich history of the chemistry of morphine. Within the following chapters, synthetic challenges of the marine terpenoids are brought into focus, the chemistry and synthetic applications of cyclobutenediones are reviewed and the utility of glycosyl iodides in the preparation of glycosides are summarized. Finally a report on a new class of spin-traping agents, azulenyl nitrones is covered. In all, five diverse subdisciplines are brought together and reviewed in this volume.…

Buch. Etat : Neu. Neuware - Volume 11 of this prestigious series, as the preceding volumes, has a dual purpose. As a textbook it is intended to be of assistance to those who wish to be introduced to a given topic in the field of magnetism without the need to read the vast amount of literature published. As a work of reference it is intended for scientists active in magnetism research. In keeping with this dual purpose, Volume 11 of the Handbook is composed of topical review articles written by leading authorities. In each of these articles an extensive description is given in graphical as well as in tabular form, much emphasis being placed on the discussion of the experimental material in the framework of physics, chemistry and materials science.Chapter one focuses on the growing interest in intermetallic compounds based on uranium. Recent research activities have finally led to the crystallisation of new concepts in actinide magnetism which, together with the large amount of experimental work are reviewed in this chapter.The last few decades have witnessed quite an extraordinary development in magnetic recording technology. In the near future magnetic recording technology will have an enormous growth potential, one of it's main aims being the further reduction in the peripheral device sizes while maintaining an increase in capacity. Chapter two deals with the magnetism and materials aspects of hard disk media which are the most prominent type of mass storage today, due to their low cost, high speed and relatively high storage capacity.Magnets based on rare earth elements are unequalled with regard to coercivity and maximum energy production. Considerable progress has been made in the development of rare earth based permanent magnets which goes hand in hand with a better understanding of the physical properties and especially the magnetism of the underlying class of materials. Chapter three presents a survey of the physical principles involved with this technique and how these can be applied advantageously to the study of strongly ferromagnetic materials.The final chapter is devoted to inelastic neutron scattering when applied to study the crystal field interaction in lanthanide compounds. Included in this review is a description of how this technique is complementary to various other modern and conventional techniques.…