Elsevier bv jan 2000 (7 résultats)

Taschenbuch. Etat : Neu. Neuware - In 1999 the IFAC/IFIP Workshop on Real Time Programming (WRTP) joined forces with the Workshop on Active and Real-Time Database Systems (ARTDB). Both series of workshops provide an excellent forum for exchanging information on recent scientific and technological advances and practices in real time computing, a field that is becoming an essential enabling discipline of both control engineering and computer science and engineering. The annual Workshop on Real Time Programming and the bi-annual Workshop on Active and Real-time Databases Systems are intended as meetings of relatively small numbers of experts in their fields taking place as truly international events. The 1999 Workshop maintained the outstanding quality of both series, providing an opportunity to assess the state-of-the-art, to present new results, and to discuss possible lines of future developments. Primarily, it focused on software development for real time systems, real time operating systems and active and real time database systems. In particular, the technical programme of the Workshop covered latest research and developments in requirements engineering, software engineering, active and real time database systems, communication and clock synchronisation, embedded systems, formal methods, operating systems and scheduling. Out of 58 submissions from 19 countries, the International Programme Committee selected 26 regular papers and 8 reserve papers for presentation at the Workshop. Contributions come from Europe, North America, Australia, and the Far East. In addition to these, the programme also featured two world renowned keynote speakers, and a discussion panel about the state-of-the-art in the field of active real time database systems.…

Buch. Etat : Neu. Neuware - Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested. …

Buch. Etat : Neu. Neuware - The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpiont of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists wiht disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pahtogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is becoming increasingly clear that large viruses (e.g. Vaccinia) and Listeria monocytogenes, share common strategies in invasion and intercellular spread.…

Buch. Etat : Neu. Neuware - This series is designed to provide a vehicle in which investigators, who have demonstrated a high degree of competence in some aspect of free radical chemistry, can present a particular area of interest. The series encompasses a wide variety of topics which are of current interest.…

Buch. Etat : Neu. Neuware - This volume presents work from six different groups working on various aspects of cycloaddition chemistry. José Mascareñas gives us a very interesting account of the chemistry of &Bgr;-alkoxy-&ggr;-pyrones and related species. Al Padwa and Chris Staub discuss further advances in rhodium carbenoid chemistry and the unusual cycloaddition processes possible with these intermediates. Higher order cycloadditions mediated by transition metals highlight Jim Rigby's update on his group's efforts in this area. Lily Lee and John Snyder present us with a detailed account of the indole ring as a dienophile, challenging us to consider the untapped potential in this area. Brian Keay and Ian Hunt discuss the intramolecular Diels-Alder reactions of furan; a report that is both top-notch science, and what could be a great learning tool for students who need to see how fundamental chemical principles can and should be applied to synthetic problems. Finally, Kay Brummond introduces us to a new version of the Pauson-Khand reactions, one that will no doubt be further exploited in productive ways by her group well into the future.…

Buch. Etat : Neu. Neuware - The International Conference on Mechanical Design and Production has over the years established itself as an excellent forum for the exchange of ideas in these established fields. The first of these conferences was held in 1979. The seventh, and most recent, conference in the series was held in Cairo during February 15-17, 2000. International engineers and scientists gathered to exchange experiences and highlight the state-of-the-art research in the fields of mechanical design and production. In addition a heavy emphasis was placed on the issue of technology transfer. Over 100 papers were accepted for presentation at the conference. Current Advances in Mechanical Design & Production VII does not, however, attempt to publish the complete work presented but instead offers a sample that represents the quality and breadth of both the work and the conference. Ten invited papers and 54 ordinary papers have been selected for inclusion in these proceedings. They cover a range of basic and applied topics that can be classified into six main categories: System Dynamics, Solid Mechanics, Material Science, Manufacturing Processes, Design and Tribology, and Industrial Engineering and its Applications.…

Buch. Etat : Neu. Neuware - This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.…