humana press jul 2009 (36 résultats)

Buch. Etat : Neu. Neuware -In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on higher eukaryote (animal) and cancer genomes. Written in the highly successful Methods in Molecular Biology¿ series format, chapters include a brief introduction to their respective subjects, lists of the necessary materials and reagents, step-by-step protocols, and time-saving notes on troubleshooting and avoiding known pitfalls.Authoritative and easy-to-use, Microarray Analysis of the Physical Genome: Methods and Protocols is of great value to the molecular biologist or computational biologist interested in understanding the principles of these analyses or in planning future experiments using microarrays to characterize the physical genome.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 236 pp. Englisch.

Buch. Etat : Neu. Neuware -Since the publication of the first edition, the number of unique heritable mtDNA mutations recognized as being associated with bioenergetic dysfunction, cell death and disease has grown. Likewise, our understanding of the basic biology of somatic mtDNA mutations continues to improve. In Mitochondrial DNA: Methods and Protocols, Second Edition, specialists from eight countries share their expertise, providing detailed protocols for studying many aspects of mtDNA. The volume is divided into three sections, which cover the transduction of information from mtDNA to functionally active respiratory complexes, mitochondrial reactive oxygen species (ROS) production as well as mtDNA damage and its repair, and the identification and quantification of heteroplasmic mtDNA mutations. Written in the highly successful Methods in Molecular Biology¿ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, Mitrochondrial DNA: Methods and Protocols, Second Edition promises to aid researchers in further expanding our knowledge of this vital area of cell biology.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 416 pp. Englisch.

Buch. Etat : Neu. Neuware -The ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular Biology¿ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 412 pp. Englisch.

Buch. Etat : Neu. Neuware -aboratory Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Lauren M. Pachman 5 Inclusion Body Myositis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 Lawrence J. Kagen 6 The Role of Muscle Biopsy in the Diagnosis of Inflammatory Myopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Sakir Humayun Gultekin 7 Electromyography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 1 Hans L. Carlson 8 Magnetic Resonance Imaging of Myopathies and Myositis . . . . . . . . . . . . . . . . . 127 Carolyn M. Sofka 9 Ultrasound in the Evaluation of the Inflammatory Myopathies . . . . . . . . . 147 Ronald S. Adler and Giovanna Garofalo vii viii Contents 10 Serological Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 Ira N.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 356 pp. Englisch.

Buch. Etat : Neu. Neuware -In the years since the release of the popular first edition, the field of High Throughput Screening (HTS) has evolved considerably, from a small niche area of study to a major, essential scientific technique. In High Throughput Screening: Methods and Protocols, Second Edition, experts in the field fully update the previous edition to best serve as an introduction to HTS for scientists who are just entering the field, and as a provider of key, significant detail so as to be useful to scientists in established HTS operations. Featuring new screening technologies as well as many well established methods, chapters offer comprehensive treatment of the activities directly related to HTS, such as compound library management, data handling, and robotics. As a volume in the highly successful Methods in Molecular Biology¿ series, this work provides the kind of meticulous description and implementation advice that is crucial for getting optimal results.Authoritative and intrinsically practical, High Throughput Screening: Methods and Protocols, Second Edition promises to share the highest knowledge and enthusiasm with all those who use this versatile technology in their own labs.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.

Buch. Etat : Neu. Neuware -Diabetes is now reaching epidemic proportions, and the associated complications of this disease can be disabling and even life-threatening. In Type 2 Diabetes: Methods and Protocols, leading investigators provide up-to-date explanations of commonly used laboratory protocols used in diabetes research. Covering the commonly described in vivo and in vitro model systems, the volume ultimately leads to an overall view of how cellular dysfunction and degeneration leads to susceptibility and diabetes disease progression. Written in the highly successful Methods in Molecular Biology¿ series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and expert notes on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Type 2 Diabetes: Methods and Protocols offers succinct, proven techniques to aid research scientists and clinicians in continuing the study of this debilitating disease.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 288 pp. Englisch.

Buch. Etat : Neu. Neuware -The book, Biomembrane Frontiers: Nanostructures, Models, and the Design of Life, a volume in the Handbook of Modern Biophysics series, is based on a workshop held on the 20th and 21st of March 2008 at the University of California Davis. Unlike other meeting monographs, the book presents the exciting frontiers of biomembrane research for both expert and student c- leagues interested in research at the interface of biology and physics. The idea of the workshop originated from discussions about how to create an effective o- reach for the NSF-NIRT joint project ¿Aerogel and Nanoporous Materials for Biomolecular Applications¿ between the Longo, Faller, and Risbud groups at UC Davis and the groups of Curt Frank at Stanford and Joe Satcher at Lawrence Livermore National Laboratory. In the p- ject we interacted with researchers from diverse backgrounds and hoped to create an oppor- nity to foster a multi- and interdisciplinary exchange of ideas. Thus, the workshop idea was c- ceived. The workshop brought together experts working on many different aspects of biological membranes: from theory and simulation, to supported model bilayers, and to clinical appli- tions. Several material scientists working on the interactions of biological membranes with b- logical or nonbiological materials also participated. Such a diverse set of experts in one meeting is unusual, as the different communities of theorists and experimentalists working on model membranes and real biological systems are typically quite distinct and do not often interact.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

Buch. Etat : Neu. Neuware -In recent years, large-scale advances in technology have led to greater understanding of the world on a much tinier scale: the biomolecular level. In Micro and Nano Technologies in Bioanalysis: Methods and Protocols, expert researchers from across the globe explore the technology which makes this analysis possible, investigating the worlds of microfluidics and nanotechnologies, and examining physical science techniques for the separation, detection, manipulation, and analysis of biomolecules. This volume contains innovative protocols on the application of microfluidics and the utilization of physical science-related technologies that will prove to be invaluable in the field of molecular biology. Chapters contain cutting edge applications of emerging nanotechnologies, including quantum dots and molecular fluorescence for the imaging and tracking of biomolecules. Composed in the highly successful Methods in Molecular Biology¿ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Comprehensive and groundbreaking, Micro and Nano Technologies in Bioanalysis: Methods and Protocols is a necessary tool for cellular biologists, biochemists, microbiologists, geneticists and medical researchers alike.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 688 pp. Englisch.

Buch. Etat : Neu. Neuware -From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex 'genome-wide' assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as 'systems biology,' and its applications in drug discovery, medicine and basic disease research. The volume is divided into three convenient sections, covering the elucidation of protein, compound and gene interactions, analytical tools, including networks, interactome and ontologies, and applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology¿ series, this work provides detailed descriptions and hands-on implementation advice. Authoritative and cutting-edge, Protein Networks and Pathway Analysis presents both 'wet lab' experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Buch. Etat : Neu. Neuware -Since its introduction almost 20 years ago, phage display technology has revolutionized approaches to the analysis of biomedical problems, quickly impacting the fields of immunology, cell biology, biotechnology, pharmacology, and drug discovery. In Antibody Phage Display: Methods and Protocols, Second Edition, expert researchers explore the latest in this cutting-edge technology, providing an invaluable resource that will guide readers in the design and execution of experiments based around antibody phage display. Chapters present a wide range of methods of isolating recombinant antibodies from phage display libraries, examine how the targets recognized by antibodies of interest can be identified, discuss the identification and exploitation of antibodies that can enter cells and bind to cytosolic targets, and include novel approaches to the expression of recombinant antibodies. Composed in the highly successful Methods in Molecular Biology¿ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Detailed and innovative, Antibody Phage Display: Methods and Protocols, Second Edition is a critical handbook on phage display technology which is certain to stimulate the reader¿s imagination as much as it will guide future practice in the laboratory.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 252 pp. Englisch.

Buch. Etat : Neu. Neuware -Cardiovascular heart disease mortality in African Americans is the highest of all major racial/ethnic subpopulations in the United States. Examining race and ethnicity, Cardiovascular Disease in Racial and Ethnic Minorities will reveal that there are unacceptable healthcare disparities in risk factor prevalence, disease states, and cardiovascular outcomes in the United States. Written by a team of experts, Cardiovascular Disease in Racial and Ethnic Minorities examines to what degree biomedical and scientific literature can clarify the impact of genetic variation versus environment as related to cardiovascular disease. Chapters illustrate the magnitude of cardiovascular and metabolic disparities and the effect of environment on diseases. 352 pp. Englisch.

Buch. Etat : Neu. Neuware -Surgical pathology is the cornerstone in the management of neoplastic disorders. Written for the practicing surgical pathologist in mind, Surgical Pathology of Endocrine and Neuroendocrine Tumors provides an up-to-date text on surgical pathology of endocrine and neuroendocrine tumors. The text begins with radiological imaging of tumors, followed by a section on fine needle aspiration biopsy. The main section focuses on surgical pathology of endocrine and neuroendocrine tumors. The volume closes with applications of molecular techniques and their potential for the future. Surgical Pathology of Endocrine and Neuroendocrine Tumors is written by a panel of internationally recognized pathologists who are not only experts in their fields, but who also contribute their own valuable insights making this new book an essential resource for practicing general and specialist surgical pathologists and pathologists in training.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 256 pp. Englisch.

Buch. Etat : Neu. Neuware - Each generation in a sexually reproducing organism such as a fly or a mouse passes through the bottleneck of meiosis, which is the specialized cell division that gives rise to haploid reproductive cells (sperm, eggs, spores, etc. ). The principal function of meiosis is to reduce the genome complement by half, which is accomplished through sequential execution of one round of DNA replication followed by two rounds of chromosome segregation. Within the extended prophase between DNA replication and the first meiotic division in most organisms, homologous maternal and paternal chromosomes pair with one another and undergo homologous recombination, which establishes physical connections that link the homologous chromosomes until the time they are separated at anaphase I. Recombination also serves to increase genetic diversity from one generation to the next by breaking up linkage groups. The unique chromosome dynamics of meiosis have fascinated scientists for well over a century, but in recent years there has been an explosion of new information about how meiotic chromosomes pair, recombine, and are segregated. Progress has been driven by advances in three main areas: (1) genetic identification of meiosis-defective mutants and cloning of the genes involved; (2) development of direct physical assays for DNA intermediates and products of recombination; and (3) increasingly sophisticated cy- logical methods that describe chromosome behaviors and the spatial and temporal patterns by which specific proteins associate with meiotic chromosomes.

Buch. Etat : Neu. Neuware -For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 312 pp. Englisch.

Buch. Etat : Neu. Neuware -This rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 720 pp. Englisch.

Buch. Etat : Neu. Neuware -This rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 716 pp. Englisch.

Buch. Etat : Neu. Neuware - Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ''state of the art'' in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Buch. Etat : Neu. Neuware -Antimicrobial Drug Resistance is the first major comprehensive reference to antimicrobial drug resistance. The first volume of the book is devoted to the biological basis of drug resistance and effective avenues for drug development. The second volume is devoted to the clinical aspects of drug resistance.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 1440 pp. Englisch.

Buch. Etat : Neu. Neuware - From the discovery of Pdx1, the first 'master gene' of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Diabetes is now reaching epidemic proportions, and the associated complications of this disease can be disabling and even life-threatening. In Type 2 Diabetes: Methods and Protocols, leading investigators provide up-to-date explanations of commonly used laboratory protocols used in diabetes research. Covering the commonly described in vivo and in vitro model systems, the volume ultimately leads to an overall view of how cellular dysfunction and degeneration leads to susceptibility and diabetes disease progression. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and expert notes on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Type 2 Diabetes: Methods and Protocols offers succinct, proven techniques to aid research scientists and clinicians in continuing the study of this debilitating disease. 288 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on higher eukaryote (animal) and cancer genomes. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include a brief introduction to their respective subjects, lists of the necessary materials and reagents, step-by-step protocols, and time-saving notes on troubleshooting and avoiding known pitfalls.Authoritative and easy-to-use, Microarray Analysis of the Physical Genome: Methods and Protocols is of great value to the molecular biologist or computational biologist interested in understanding the principles of these analyses or in planning future experiments using microarrays to characterize the physical genome. 236 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease. 160 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death. 412 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the publication of the first edition, the number of unique heritable mtDNA mutations recognized as being associated with bioenergetic dysfunction, cell death and disease has grown. Likewise, our understanding of the basic biology of somatic mtDNA mutations continues to improve. In Mitochondrial DNA: Methods and Protocols, Second Edition, specialists from eight countries share their expertise, providing detailed protocols for studying many aspects of mtDNA. The volume is divided into three sections, which cover the transduction of information from mtDNA to functionally active respiratory complexes, mitochondrial reactive oxygen species (ROS) production as well as mtDNA damage and its repair, and the identification and quantification of heteroplasmic mtDNA mutations. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, Mitrochondrial DNA: Methods and Protocols, Second Edition promises to aid researchers in further expanding our knowledge of this vital area of cell biology. 416 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Representing the most up-to-date knowledge of this family of diseases, this book presents a comprehensive overview of the inflammatory myopathies, including dermatomyositis, polymyositis and inclusion body myositis. The Inflammatory Myopathies covers clinical presentation, diagnosis and classification, ongoing assessment, treatment and pathogenesis. Physical findings, laboratory studies, imaging modalities and biopsy are discussed. The role and mechanism of the inflammatory response is also explored. The Inflammatory Myopathies is the gold-standard in the field, an essential resource for rheumatologists, neurologists and all healthcare professionals who treat afflicted patients. 356 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the years since the release of the popular first edition, the field of High Throughput Screening (HTS) has evolved considerably, from a small niche area of study to a major, essential scientific technique. In High Throughput Screening: Methods and Protocols, Second Edition, experts in the field fully update the previous edition to best serve as an introduction to HTS for scientists who are just entering the field, and as a provider of key, significant detail so as to be useful to scientists in established HTS operations. Featuring new screening technologies as well as many well established methods, chapters offer comprehensive treatment of the activities directly related to HTS, such as compound library management, data handling, and robotics. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work provides the kind of meticulous description and implementation advice that is crucial for getting optimal results.Authoritative and intrinsically practical, High Throughput Screening: Methods and Protocols, Second Edition promises to share the highest knowledge and enthusiasm with all those who use this versatile technology in their own labs. 280 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cardiovascular heart disease mortality in African Americans is the highest of all major racial/ethnic subpopulations in the United States. Examining race and ethnicity, Cardiovascular Disease in Racial and Ethnic Minorities will reveal that there are unacceptable healthcare disparities in risk factor prevalence, disease states, and cardiovascular outcomes in the United States. Written by a team of experts, Cardiovascular Disease in Racial and Ethnic Minorities examines to what degree biomedical and scientific literature can clarify the impact of genetic variation versus environment as related to cardiovascular disease. Chapters illustrate the magnitude of cardiovascular and metabolic disparities and the effect of environment on diseases. 352 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -HANDBOOK OF MODERN BIOPHYSICSSeries Editor Thomas Jue, PhDHandbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fundamental concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to explore independently the ideas presented.Volume II: Biomembrane Frontiers: Nanostructures, Models, and the Design of LifeEditors: Roland Faller, PhD, Thomas Jue, PhD, Marjorie L. Longo, PhD, and Subhash H. Risbud, PhDIn Biomembrane Frontiers: Nanostructures, Models, and the Design of Life, prominent researchers have established a foundation for the study of biophysics related to the following topics:Perspectives: Complexes in Liquids, 1900-2008Molecular Theory Applied to Lipid Bilayers and Lipid-Protein InteractionsMembrane Elasticity and Mediated Interactions in Continuum Theory: A Differential Geometric ApproachStructure and Dynamics of Lipid Monolayers: Theory and ApplicationsMultiscale Modeling of Supported Lipid BilayersCollective Dynamics in Lipid Membranes:From Pore Formation to Flip-FlopsSpatiotemporal Organization of Spin-Coated Supported Model MembranesNanopore Analysis of Nucleic Acids: Single-MoleculeStudies of Molecular Dynamics, Structure, and Base SequenceComplex Applications of Simple FRAP on MembranesPunching Holes in Membranes: HowOligomericPore-Forming Proteins and Lipids Cooperate to Form Aqueous Channels in MembranesMorphogens, Membranes and Mechanotransduction in Articular CartilageLifecycle of a Lipoprotein from a Biophysical PerspectiveTargeting Apolipoproteins in Magnetic Resonance ImagingAbout the EditorsThe editors are internationally recognized biomembrane experts and have published extensively on the structure, dynamics, and function of model and cellular membranes. Roland Faller is an Associate Professor and the Joe & Essie Smith Endowed Chair in the Department of Chemical Engineering & Materials Science at the University of California Davis. He develops and uses modern molecular simulation techniques for soft condensed matter systems, particularly biomembranes. Thomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California Davis. He develops and applies magnetic resonance techniques to study biochemical regulation invivo. Marjorie L. Longo is a professor in the Department of Chemical Engineering andMaterials Science at the University of California Davis. She applies microscopy techniques to study surface and transport properties of lipid bilayers and monolayers. Subhash H. Risbud is the Blacutt-Underwood Distinguished Professor of Materials Science in the Department of Chemical Engineering and Materials Science at the University of California at Davis and a Visiting Professor at Stanford University. His group develops new materials for nano- and biotechnology. The materials include glasses, ceramics, and nanoporous substrates for biological membranes. 348 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, large-scale advances in technology have led to greater understanding of the world on a much tinier scale: the biomolecular level. InMicro and Nano Technologies in Bioanalysis: Methods and Protocols, expert researchers from across the globe explore the technology which makes this analysis possible, investigating the worlds of microfluidics and nanotechnologies, and examining physical science techniques for the separation, detection, manipulation, and analysis of biomolecules. This volume contains innovative protocols on the application of microfluidics andthe utilization of physical science-related technologies that will prove to be invaluable in the field of molecular biology. Chapters contain cutting edge applications of emerging nanotechnologies, including quantum dots and molecular fluorescence for the imaging and tracking of biomolecules. Composed in the highly successful Methods in Molecular Biology(TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Comprehensive and groundbreaking, Micro and Nano Technologies in Bioanalysis: Methods and Protocols is a necessary tool for cellular biologists, biochemists, microbiologists, geneticists and medical researchers alike. 688 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex 'genome-wide' assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as 'systems biology,' and its applications in drug discovery, medicine and basic disease research. The volume is divided into three convenient sections, covering the elucidation of protein, compound and gene interactions, analytical tools, including networks, interactome and ontologies, and applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work provides detailed descriptions and hands-on implementation advice. Authoritative and cutting-edge, Protein Networks and Pathway Analysis presents both 'wet lab' experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field. 424 pp. Englisch.