solitek publishing (4 résultats)

Etat : New.

Paperback or Softback. Etat : New. The Solid-State Mindset: Lessons, Surprises, and Strategies from the Front Lines of Drug Development. Book.

Paperback. Etat : new. Paperback. Drugs don't fail because their chemistry is wrong-they fail because their physical reality is misunderstood.Most molecules entering development today are poorly soluble, structurally complex, and polymorphically rich. They behave unpredictably under stress, at scale, or in formulation-unless their solid-state landscape is understood from the start.The Solid-State Mindset is a practical, insightful journey through the science that underpins every successful small-molecule program: polymorphism and crystallisationsolubility and dissolutionamorphous materials and particle engineeringearly formulation and preclinical vehiclesCMC strategy and regulatory expectationssolid-form IP, risk management, and the hidden business consequencesDrawing on years of hands-on experience in the pharmaceutical industry, Victor M. Diaz Perez brings together real case studies-including ritonavir, paroxetine, and gatifloxacin-along with clear explanations of the physical chemistry behind them.This book is not a manual. It is a perspective, a way of thinking that helps scientists, founders, CMC leaders, and generic manufacturers make better decisions, earlier, with fewer surprises.If you work with small molecules, this book will change how you see your drug. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Paperback. Etat : new. Paperback. Drugs don't fail because their chemistry is wrong-they fail because their physical reality is misunderstood.Most molecules entering development today are poorly soluble, structurally complex, and polymorphically rich. They behave unpredictably under stress, at scale, or in formulation-unless their solid-state landscape is understood from the start.The Solid-State Mindset is a practical, insightful journey through the science that underpins every successful small-molecule program: polymorphism and crystallisationsolubility and dissolutionamorphous materials and particle engineeringearly formulation and preclinical vehiclesCMC strategy and regulatory expectationssolid-form IP, risk management, and the hidden business consequencesDrawing on years of hands-on experience in the pharmaceutical industry, Victor M. Diaz Perez brings together real case studies-including ritonavir, paroxetine, and gatifloxacin-along with clear explanations of the physical chemistry behind them.This book is not a manual. It is a perspective, a way of thinking that helps scientists, founders, CMC leaders, and generic manufacturers make better decisions, earlier, with fewer surprises.If you work with small molecules, this book will change how you see your drug. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.