springer basel springer basel mär 2012 (11 résultats)

Buch. Etat : Neu. Neuware -This book is a collection of essays on the reception of Leibniz¿s thinking in the sciences and in the philosophy of science in the 19th and 20th centuries. Authors studied include C.F. Gauss, Georg Cantor, Kurd Lasswitz, Bertrand Russell, Ernst Cassirer, Louis Couturat, Hans Reichenbach, Hermann Weyl, Kurt Gödel and Gregory Chaitin. In addition, we consider concepts and problems central to Leibniz¿s thought and that of the later authors: the continuum, space, identity, number, the infinite and the infinitely small, the projects of a universal language, a calculus of logic, a mathesis universalis etc. The book brings together two fields of research in the history of philosophy and of science (research on Leibniz, and the research concerned with some major developments in the 19th and 20th centuries); it describes how Leibniz¿s thought appears in the works of these authors, in order to better understand Leibniz¿s influence on contemporary science and philosophy; but it also assesses that reception critically, confronting it in particular with the current state of Leibniz research and with the various editions of his work.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 292 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success.This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 116 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -The Autumn 2011 (vol. 13 no. 3) issue of the Nexus Network Journal features nine papers guest edited by José Calvo-Lopez dedicated to the theme ¿From Mediaeval Stonecutting to Projective Geometry ¿. This is an outgrowth of the session by the same name which took place during the eighth international, interdisciplinary conference ¿Nexus 2010: Relationships between Architecture and Mathematics, held in Porto, Portugal, in June 2010. The topics discussed range from the theoretical mathematics to built examples both historical and contemporary. The issue is completed with other research papers, conference reports and book reviews.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 296 pp. Englisch.

Buch. Etat : Neu. Neuware -In the 1970s Hirzebruch and Zagier produced elliptic modular forms with coefficients in the homology of a Hilbert modular surface. They then computed the Fourier coefficients of these forms in terms of period integrals and L-functions. In this book the authors take an alternate approach to these theorems and generalize them to the setting of Hilbert modular varieties of arbitrary dimension. The approach is conceptual and uses tools that were not available to Hirzebruch and Zagier, including intersection homology theory, properties of modular cycles, and base change. Automorphic vector bundles, Hecke operators and Fourier coefficients of modular forms are presented both in the classical and adèlic settings. The book should provide a foundation for approaching similar questions for other locally symmetric spaces.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 272 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -This book presents recent results on nonlinear parabolic-hyperbolic coupled systems such as the compressible Navier-Stokes equations, and liquid crystal system. It summarizes recently published research by the authors and their collaborators, but also includes new and unpublished material. All models under consideration are built on compressible equations and liquid crystal systems. This type of partial differential equations arises not only in many fields of mathematics, but also in other branches of science such as physics, fluid dynamics and material science.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 184 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the 'First Inter national Conference on Oxidative Stress and Aging' in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 416 pp. Englisch.

Buch. Etat : Neu. Neuware -Medical research involving human subjects has contributed to considerable advancements in our knowledge, and to medical benefits. At the same time the development of new technologies as well as further globalisation of medical research raises questions that require the attention of researchers from a range of disciplines. This book gathers the contributions of researchers from nine different countries, who analyse recent developments in medical research from ethical, historical, legal and socio-cultural perspectives. In addition to reflections on innovations in science such as genetic databases and the concept of ¿targeted therapy¿ the book also includes analyses regarding the ethico-legal regulation of new technologies such as human tissue banking or the handling of genetic information potentially relevant for participants in medical research. Country and culture-specific aspects that are relevant to human medical research from a global perspective also play a part. The value of multi- and interdisciplinary analysis that includes the perspectives of scholars from normative and empirical disciplines is a shared premise of each contribution.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 204 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Volume 45 of 'Progress in Drug Research' contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug design, with natri uretic hormones and with the recent developments in the chemotherapy of osteoporosis. In the 36 years that PDR has existed, the Editor has enjoyed the valu able help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a series of monographs. So far, it has been the Editor's intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the nonspecialist, who can obtain an overview of a particular field of drug research in a relatively short time.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 392 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -One of the currently most expanding and exciting areas in cardiovascular research is the study of receipt and dispatch of chemical signals by different cell types. Major progress has been made during the last years and a number of intercellular mediators have been structurally identified and their regulation studied. The impressive developments in molecular biology have provided most effective tools, enabling us to understand message generation in much more detail than anyone would have appreciated a couple of years ago. These developments also have a major impact on cardiovascular pharmacology. This involves both the molecular design of new drugs as well as an improved understanding of how established drugs act. Clearly, changes in one mediator system will also affect others and it might be difficult to take out just one factor and to ignore others. This is definitely true for myocardial ischemia where many different mediators are synthesized and released at about the same time, resulting in a complex picture of events and an even more difficult selection of the most appropriate drug therapy.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 460 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.