springer milan springer milan nov 2014 (50 résultats)

Taschenbuch. Etat : Neu. Neuware -This handbook is a concise practical guide for residents and general radiologists that will offer reliable assistance during the performance and reporting of multidetector row computed tomography and magnetic resonance imaging in patients with Liver Bile Ducts and Pancreas conditions. It is organized alphabetically, primarily according to disease or condition, permitting easy and fast consultation. Entries typically include a short description of pathological and clinical characteristics, guidance on selection of the most appropriate imaging technique, a schematic review of potential diagnostic clues, and useful tips and tricks. Some helpful illustrations and schemes are also included. The book is the fourth in the new Springer handbook series, A-Z Notes in Radiological Practice and Reporting.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -The interaction between mathematicians and statisticians reveals to be an effective approach to the analysis of insurance and financial problems, in particular in an operative perspective.The Maf2006 conference, held at the University of Salerno in 2006, had precisely this purpose and the collection published here gathers some of the papers presented at the conference and successively worked out to this aim. They cover a wide variety of subjects in insurance and financial fields.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -The increasingly risky environment in which companies operate is characterized by a rising number of risk components, factors, sources, and drivers. The identification, evaluation, and management of these risks require the capability to coordinate various skills within a company and in upstream and downstream relationships. This handbook provides an integrated approach to the assessment, transfer, and communication of critical risks and highlights emerging methodologies that can help to protect businesses from adverse events and their effects. It explains how different risk management perspectives should be combined, and in particular how the corporate governance vision should be integrated with the perspectives of operations management, financial management, and business continuity management. In this sense the handbook provides concrete directions on how to develop a risk management team and culture, taking into account business challenges and employing appropriate managerial tools.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 152 pp. Englisch.

Buch. Etat : Neu. Neuware -Thisencompassing volumegathers contributions by renowned experts in the field of pediatric urology to offer a systematic and complete review of the field. The book opens with a general section covering the basis of renal function from the fetus to adulthood, diagnostic imaging, anesthesia and infections. In subsequent sections on the kidneys, upper urinary tract, bladder, urethra and genitalia, specific anomalies are described in depth, from embryological, clinical and diagnostic aspects through to surgical treatment options. Detailed attention is devoted to the role of new technologies such as endoscopic and robotic surgery, but without disregarding the classical principles of pediatric urologic surgery. Urogenital tumors are fully covered and the book closes with a large chapter on renal transplantation. Numerous black and white and color illustrations will assist the reader in better understanding the various anomalies and the surgical procedures.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch.

Buch. Etat : Neu. Neuware -MRI provides the best means of imaging the bone marrow directly and of non-invasively assessing its composition. Normal age-related bone marrow changes, alterations related to red marrow reconversion, and pathological bone marrow processes generally conform to certain patterns that reflect the underlying marrow changes and can be clearly recognized on MR images. In addition to conventional pulse sequences, advanced MRI techniques such as Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging depict marrow changes at the microvascular and cellular level respectively.This book provides radiologists with in-depth information on the MRI appearances of normal, abnormal and treated marrow following a structured, pattern-based approach. MRI findings for various diseases that affect the bone marrow, particularly those of a malignant nature, are presented in detail. MRI pattern recognition not only offers a systematic approach to image interpretation and diagnosis but also has prognostic implications with regard to some disease entities. Each chapter includes a wealth of high-quality images, together with Key Points summarizing the most important information.In addition to radiologists, practitioners with an interest in hematology and oncology will find this textbook-atlas to be a valuable resource for the latest, clinically relevant advances in bone marrow imaging.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Not nothing without you but not the same Erich Fried (1979) How do I know that I am the person who is moving The neuroscience of action has identified specific cognitive processes that allow the organism to refer the cause or origin of an action to its agent. This sense of agency has been defined as the sense that I am the one who is causing or generating an action or a certain thought in my stream of consciousness. As such, one can distinguish actions that are self-generated from those generated by others, giving rise to the experience of a self-other disti- tion in the domain of action. A tentative list of the features distinguishing the concept of agency includes awareness of a goal, of an intention to act, and of initiation of action; awareness of movements; a sense of activity, of mental effort, and of control; and the concept of authorship. However, it remains unclear how these various aspects of action and agency are related, to what extent they are dissociable, and whether some are more basic than others. Their sources remain to be specified and their relationship to action specification and action control mechanism is as yet unknown.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -(i.e., thedisplacement current introducedby Maxwell)or, alternatively,neglectingthe time derivative of the magnetic induction.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Intensive care is a rapidly changing area of medicine, and after four years from the 2nd edition the volume editors and authors have deemed necessary to update it. In the recent years, in fact, five new randomised controlled trials and five new meta-analyses demonstrate that selective decontamination of the digestive tract [SDD] is an antimicrobial prophylaxis to prevent severe infections of not only lower airways but also of blood. Additionally, SDD has been shown to reduce inflammation including multiple organ failure and mortality. An intriguing observation is the evidence that SDD using parenteral and enteral antimicrobials reduces rather than increases antimicrobial resistance. Moreover, a new chapter on microcirculation had been added.The volume will be an invaluable tool for all those requiring in depth knowledge in the ever expanding field of infection control.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 532 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Football is probably the most widespread sport in the world: youngsters, adults, women, amateurs, beginners, professionals all make up a legion of practitioners. Lesions associated with football are on the increase and their typology has also changed over the years. Football, like many other sports, has undergone major changes: the increase in the intensity and speed of the game, the modern training methodologies, the technical and tactical innovations are all factors contributing to increased risks of traumatic injury. The footballers, the trainers, the sport's medical staff are asking for greater information and knowledge on the traumatic lesions associated with this sport. The primary role of those who are concerned with the health of footballers is to enforce preventive measures to reduce wherever possible the risks of trauma.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -In questo volume: Fondamentali di patogenesi e di diagnosi clinica e strumentale - Complicanze dei tumori - Complicanze neurologiche delle malattie internistiche e della gravidanza - Traumi del sistema nervoso centrale e periferico - Infezioni.Inoltre, principi generali di: Terapia del dolore - Neuroradiologia intervenzionale - Neuroanestesia - Riabilitazione motoria - Riabilitazione cognitiva - Terapia genica - Farmacoterapia psichiatrica - Terapia palliativa.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 696 pp. Italienisch.

Taschenbuch. Etat : Neu. Neuware -Questovolume illustra le principali tecniche di preparazione del campione con particolare enfasi sulle tecniche innovative e sui sistemi on-line che mirano a ridurre il tempo di analisi, la manipolazione del campione e il consumo di solventi. L¿analisi chimica prevede infattigeneralmente una fase di preparazione del campione, che ha lo scopo di isolare gli analiti di interesse dalla matrice ed eliminare i potenziali interferenti prima della determinazione analitica finale. Il testo è arricchito da numerosi esempi applicativi nel settore dell¿analisi chimica degli alimenti e in particolare dei contaminanti. Il volume è rivolto, oltre che a studenti universitari, dottorandi e ricercatori, anche ai tecnici di laboratorio che devono acquisire conoscenze e competenze per la preparazione del campione per l¿analisi chimica nel settore alimentare, ambientale e farmaceutico.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Italienisch.

Taschenbuch. Etat : Neu. Neuware -Questo libro riporta lo stato dell¿arte delle più comuni malattie dell¿apparato respiratorio. La prima parte è dedicata all¿anatomia del polmone, alla regolazione della respirazione e alla meccanica respiratoria, seguita dall¿esame funzionale del paziente respiratorio e dalla diagnostica invasiva e non invasiva, inclusa la diagnostica per immagini in pneumologia. Nella descrizione delle malattie particolare importanza è stata data nel chiarire il 'perché' dei diversi sintomi e segni clinici mentre l¿approccio terapeutico, confrontato con le linee guida internazionali, fa comunque riferimento alla vasta esperienza clinica degli autori. L¿obiettivo principale di questo libro è quindi quello di riportare le più recenti acquisizioni nella fisiologia, fisiopatologia e clinica delle malattie dell¿apparato respiratorio, inclusa la ventilazione meccanica non invasiva, l¿ossigenoterapia e la riabilitazione respiratoria, e di combinare una chiara descrizione della fisiopatologia respiratoria con enfasi alla sua applicazione clinica. Il volume è rivolto sia agli studenti del corso di laurea specialistica in medicina e chirurgia, sia agli specializzandi in malattie dell¿apparato respiratorio. Rappresenta inoltre un valido riferimento per il medico di medicina generale, soprattutto quando quest¿ultimo intenda aumentare le proprie conoscenze cliniche, diagnostiche e terapeutiche nel settore delle patologie respiratorie, branca che sempre più frequentemente coinvolge il medico e lo specialista nella risoluzione di casi anche molto complessi.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 812 pp. Italienisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This handbook is a concise practical guide for residents and general radiologists that will offer reliable assistance during the performance and reporting of multidetector row computed tomography and magnetic resonance imaging in patients with Liver Bile Ducts and Pancreas conditions. It is organized alphabetically, primarily according to disease or condition, permitting easy and fast consultation. Entries typically include a short description of pathological and clinical characteristics, guidance on selection of the most appropriate imaging technique, a schematic review of potential diagnostic clues, and useful tips and tricks. Some helpful illustrations and schemes are also included. The book is the fourth in the new Springer handbook series, A-Z Notes in Radiological Practice and Reporting. 136 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We all know the hard fact: neither wealth nor income is ever uniform for us all. Justified or not, they are unevenly distributed; few are rich and many are poor! Investigations for more than hundred years and the recent availability of the income distribution data in the internet (made available by the finance ministries of various countries; from the tax return data of the income tax departments) have revealed some remarkable features. Irrespective of many differences in culture, history, language and, to some extent, the economic policies followed in different countries, the income distribution is seen to fol low a particular universal pattern. So does the wealth distribution. Barring an initial rise in population with income (or wealth; for the destitutes), the population decreases either exponentially or in a log-normal way for the ma jority of 'middle income' group, and it eventually decreases following a power law (Pareto law, following Vilfredo Pareto's observation in 1896) for the rich est 5-10 % of the population! This seems to be an universal feature - valid for most of the countries and civilizations; may be in ancient Egypt as well! Econophysicists tried to view this as a natural law for a statistical ma- body-dynamical market system, analogous to gases, liquids or solids: classical or quantum. 260 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book aims to investigate methods and techniques for spatial statistical analysis suitable to model spatial information in support of decision systems. Over the last few years there has been a considerable interest in these tools and in the role they can play in spatial planning and environmental modelling.One of the earliest and most famous definition of spatial planning was 'a geographical expression to the economic, social, cultural and ecological policies of society': borrowing from this point of view, this text shows how an interdisciplinary approach is an effective way to an harmonious integration of national policies with regional and local analysis.A wide range of spatial models and techniques is, also, covered: spatial data mining, point processes analysis, nearest neighbor statistics and cluster detection, Fuzzy Regression model and local indicators of spatial association; all of these tools provide the policy-maker with a valuable support to policy development. 168 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The interaction between mathematicians and statisticians reveals to be an effective approach to the analysis of insurance and financial problems, in particular in an operative perspective. The Maf2006 conference, held at the University of Salerno in 2006, had precisely this purpose and the collection here published gathers some of the papers presented at the conference and successively worked out to this aim. They cover a wide variety of subjects in insurance and financial fields, all treated in light of the successful cooperation between the two quantitative methods. 224 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In questo volume: Fondamentali di patogenesi e di diagnosi clinica e strumentale - Complicanze dei tumori - Complicanze neurologiche delle malattie internistiche e della gravidanza - Traumi del sistema nervoso centrale e periferico - Infezioni.Inoltre, principi generali di: Terapia del dolore - Neuroradiologia intervenzionale - Neuroanestesia - Riabilitazione motoria - Riabilitazione cognitiva - Terapia genica - Farmacoterapia psichiatrica - Terapia palliativa. 696 pp. Italienisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The book aims to investigate methods and techniques for spatial statistical analysis suitable to model spatial information in support of decision systems. Over the last few years there has been a considerable interest in these tools and in the role they can play in spatial planning and environmental modelling.One of the earliest and most famous definition of spatial planning was ¿a geographical expression to the economic, social, cultural and ecological policies of society¿: borrowing from this point of view, this text shows how an interdisciplinary approach is an effective way to an harmonious integration of national policies with regional and local analysis.A wide range of spatial models and techniques is, also, covered: spatial data mining, point processes analysis, nearest neighbor statistics and cluster detection, Fuzzy Regression model and local indicators of spatial association; all of these tools provide the policy-maker with a valuable support to policy development.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -We all know the hard fact: neither wealth nor income is ever uniform for us all. Justified or not, they are unevenly distributed; few are rich and many are poor! Investigations for more than hundred years and the recent availability of the income distribution data in the internet (made available by the finance ministries of various countries; from the tax return data of the income tax departments) have revealed some remarkable features. Irrespective of many differences in culture, history, language and, to some extent, the economic policies followed in different countries, the income distribution is seen to fol low a particular universal pattern. So does the wealth distribution. Barring an initial rise in population with income (or wealth; for the destitutes), the population decreases either exponentially or in a log-normal way for the ma jority of 'middle income' group, and it eventually decreases following a power law (Pareto law, following Vilfredo Pareto's observation in 1896) for the rich est 5-10 % of the population! This seems to be an universal feature - valid for most of the countries and civilizations; may be in ancient Egypt as well! Econophysicists tried to view this as a natural law for a statistical ma- body-dynamical market system, analogous to gases, liquids or solids: classical or quantum.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The idea for this text stemmed from the fruitful experience gathered during the training course of 9 Nigerian university students organized in Naples from 3 to 18 September 2008 by the team of Fondazione IDIS-Città della Scienza under the project Science Centre Owerri. The training course turned out to be not only an educational opportunity to acquire knowledge and skills for these students, but also a real and practical tool that later led to the realization of the first Science Festival of Owerri in Nigeria in May 2009. This in turn sparked the idea of creating a highly practical handbook for those who want to face the challenge of developing new projects for the dissemination and socialization of science in developing countries. In these countries, the role of scientific education and training in schools is not sufficient to arouse scientific curiosity among young people and make the population aware of the importance of scientific knowledge in everyday life. Moreover science and technology are indispensable tools for people's empowerment and should be supported with actions that encourage curiosity about science and the intelligent use of technology to bridge the divide with developed countries. It is therefore necessary to set up activities that are carefully targeted to promote and communicate science. The text has been designed as a practical guide to be used in a variety of contexts: scientific events or more structured science festivals, training, the creation of scientific cultural associations, and the development of new science centres. Besides being an excellent tool for training and supporting the design and planning phases, the manual can also be used as a reference work for institutions and local cultural services which have to select projectsof this type. 248 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The increasingly risky environment in which companies operate is characterized by a rising number of risk components, factors, sources, and drivers. The identification, evaluation, and management of these risks require the capability to coordinate various skills within a company and in upstream and downstream relationships. This handbook provides an integrated approach to the assessment, transfer, and communication of critical risks and highlights emerging methodologies that can help to protect businesses from adverse events and their effects. It explains how different risk management perspectives should be combined, and in particular how the corporate governance vision should be integrated with the perspectives of operations management, financial management, and business continuity management. In this sense the handbook provides concrete directions on how to develop a risk management team and culture, taking into account business challenges and employing appropriate managerial tools. 152 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Throughout the history of economics, a variety of analytical tools have been borrowed from the so-called exact sciences. As Schoe er (1955) puts it: 'They have taken their mathematics and their ded- tive techniques from physics, their statistics from genetics and agr- omy, their systems of classi cation from taxonomy and chemistry, their model-construction techniques from astronomy and mechanics, and their methods of analysis of the consequences of actions from en- neering'. The possibility of similarities of structure in mathematical models of economic and physical systems has been an important f- tor in the development of neoclassical theory. To treat the state of an economy as an equilibrium, analogous to the equilibrium of a mech- ical system has been a key concept in economics ever since it became a mathematically formalized science. Adopting a Newtonian paradigm neoclassical economics often is based on three fundamental concepts. Firstly, the representative agent who is a scale model of the whole society with extraordinary capacities, particularly concerning her - pability of information processing and computation. Of course, this is a problematic reduction as agents are both heterogeneous and bou- edly rational and limited in their cognitive capabilities. Secondly, it often con ned itself to study systems in a state of equilibrium. But this concept is not adequate to describe and to support phenomena in perpetual motion. 188 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Not nothing without you but not the same Erich Fried (1979) How do I know that I am the person who is moving The neuroscience of action has identified specific cognitive processes that allow the organism to refer the cause or origin of an action to its agent. This sense of agency has been defined as the sense that I am the one who is causing or generating an action or a certain thought in my stream of consciousness. As such, one can distinguish actions that are self-generated from those generated by others, giving rise to the experience of a self-other disti- tion in the domain of action. A tentative list of the features distinguishing the concept of agency includes awareness of a goal, of an intention to act, and of initiation of action; awareness of movements; a sense of activity, of mental effort, and of control; and the concept of authorship. However, it remains unclear how these various aspects of action and agency are related, to what extent they are dissociable, and whether some are more basic than others. Their sources remain to be specified and their relationship to action specification and action control mechanism is as yet unknown. 212 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This encompassing volume gathers contributions by renowned experts in the field of pediatric urology to offer a systematic and complete review of the field. The book opens with a general section covering the basis of renal function from the fetus to adulthood, diagnostic imaging, anesthesia and infections. In subsequent sections on the kidneys, upper urinary tract, bladder, urethra and genitalia, specific anomalies are described in depth, from embryological, clinical and diagnostic aspects through to surgical treatment options. Detailed attention is devoted to the role of new technologies such as endoscopic and robotic surgery, but without disregarding the classical principles of pediatric urologic surgery. Urogenital tumors are fully covered and the book closes with a large chapter on renal transplantation. Numerous black and white and color illustrations will assist the reader in better understanding the various anomalies and the surgical procedures. 420 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - MRI provides the best means of imaging the bone marrow directly and of non-invasively assessing its composition. Normal age-related bone marrow changes, alterations related to red marrow reconversion, and pathological bone marrow processes generally conform to certain patterns that reflect the underlying marrow changes and can be clearly recognized on MR images. In addition to conventional pulse sequences, advanced MRI techniques such as Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging depict marrow changes at the microvascular and cellular level respectively. This book provides radiologists with in-depth information on the MRI appearances of normal, abnormal and treated marrow following a structured, pattern-based approach. MRI findings for various diseases that affect the bone marrow, particularly those of a malignant nature, are presented in detail. MRI pattern recognition not only offers a systematic approach to image interpretation and diagnosis but also has prognostic implications with regard to some disease entities. Each chapter includes a wealth of high-quality images, together with Key Points summarizing the most important information. In addition to radiologists, practitioners with an interest in hematology and oncology will find this textbook-atlas to be a valuable resource for the latest, clinically relevant advances in bone marrow imaging. 188 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics. 412 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Here is a new book on methods and issues in clinical research. Its objectives can be summarized in three points. 1. Integrate medical and statistical components of clinical research. 2. Do justice to the operational and practical requirements of clinical research. 3. Give space to the ethical implications of methodological issues in clinical research. The book ends with a brief description of the drug development process and the phases of clinical development. 372 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book deals with the mathematical analysis and the numerical approximation of time-harmonic eddy current problems. It is self-contained and suitable for mathematicians and engineers working in the field, and also accessible for beginners. Depending on the choice of the physical unknowns, these problems are formulated in different variational ways, with specific attention to the topology of the computational domain. Finite elements of nodal or edge type are used for numerical approximation, and a complete analysis of convergence is performed. A specific feature of the book is the emphasis given to saddle-point formulations in terms of the magnetic and electric fields. New results for voltage or current intensity excitation problems are also presented. 364 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Intensive care is a rapidly changing area of medicine, and after four years from the 2nd edition the volume editors and authors have deemed necessary to update it. In the recent years, in fact, five new randomised controlled trials and five new meta-analyses demonstrate that selective decontamination of the digestive tract [SDD] is an antimicrobial prophylaxis to prevent severe infections of not only lower airways but also of blood. Additionally, SDD has been shown to reduce inflammation including multiple organ failure and mortality. An intriguing observation is the evidence that SDD using parenteral and enteral antimicrobials reduces rather than increases antimicrobial resistance. Moreover, a new chapter on microcirculation had been added. The volume will be an invaluable tool for all those requiring in depth knowledge in the ever expanding field of infection control. 532 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease. Several pathophysiologic mechanisms have been postulated to explain the relationship between renal dysfunction and cardiovascular disease. Recent studies indicate an integrated response of the vascular smooth muscles and glomerular mesangial cells to traditional and uremia related cardiovascular risk factors. Traditional risk factors can incite renal impairment and cardiac damage. As renal function deteriorates, uremia-related risk factors play an increasing role both in reduction in glomerular filtration rate and cardiovascular damage. Several uremia related factors such as uncontrolled hypertension, disturbed glucose insulin metabolism, microalbuminuria, phosphate retention, secondary hyperparathyroidism, myocardial and vascular calcification, hypertensive-uremic cardiomyopathy, inflammation, oxidant injury, and neurohormonal dysregulation have been implicated in the pathogenesis of the cardiorenal syndrome. Recent data suggest that management of the cardiorenal syndrome requires aggressive control of traditional risk factors as well novel approaches to prevent or reverse uremia -related processes.This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome including epidemiology, pathophysiologic mechanisms, and therapeutic approaches. 416 pp. Englisch.