springer new york jun 2009 (44 résultats)

Taschenbuch. Etat : Neu. Neuware -This book will be a key trailblazer in a new and upcoming field. The author¿s predictive approach relies on simple and intuitive probability formulations that will appeal to readers with a modest knowledge of astronomy, mathematics, and statistics. Wells¿ carefully erected theory stands on a sure footing and thus should serve as the basis of many rational predictions of survival in the face of not only natural disasters such as hits by asteroids or comets, but perhaps more surprisingly from man-made hazards arising from genetic engineering or robotics.Any formula for predicting human survival will invite controversy. Dr Wells counters anticipated criticism with a thorough approach in which four lines of reasoning are used to arrive at the same survival formula. One uses empirical survival statistics for business firms and stage shows. Another is based on uncertainty of risk rates. The third, more abstract, invokes Laplace¿s principle of insufficient reason and involves an observer¿s random arrival in the lifetime of the entity (the human race) in question. The fourth uses Bayesian theory.The author carefully explains and gives examples of the conditions under which his principle is valid and provides evidence that can counteract the arguments of critics who would reject it entirely. His deflection of possible criticisms results from two major premises: selecting the proper random variable and ¿reference class¿ to make predictions, and the recognition that if one does not know the law that governs a process, then the best prediction that can be made is his own formula.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -To commemorate the momentous 50th anniversary of Yuri Gagarin¿s pioneering journey into space on 12th April 2011, a series of five books ¿ to be published annually ¿ will explore this half century, decade by decade, to discover how humanity¿s knowledge of flying, working and living in space has changed. Each volume will focus not only upon the individual missions within ¿its¿ decade, but also upon the key challenges facing human space exploration at specific points within those 50 years: from the simple problems of breathing and eating in space to the challenges of venturing outside in a pressurised spacesuit and locomotion on the Moon.The first volume of this series will focus upon the 1960s, exploring each mission from April 1961 to April 1971 in depth: from the pioneering Vostok flights to the establishment of the first Salyut space station and from Alan Shepard¿s modest sub-orbital ¿hop¿ into space to his triumphant arrival at the Moon¿s Fra Mauro foothills almost a decade later.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 512 pp. Englisch.

Buch. Etat : Neu. Neuware -More people in communities of color are contracting, living with, and being treated for HIV/AIDS than ever before. In 2005, 71% of new AIDS cases were diagnosed in people of color. The rate of HIV infection in the African-American community alone has increased from 25% of total cases diagnosed in 1985 to 50% in 2005. Latinos similarly comprise a disproportionate segment of the AIDS epidemic: though they make up only 14% of the U.S. population, 20% of AIDS cases diagnosed in 2004 were Latino/a.Though the number of racial and ethnic minority HIV/AIDS cases continues to grow, the health care community has been unable to adequately meet the unique medical needs of these populations. African-American, Latino/Latina, and other patients of color are less likely to seek medical care, have sufficient access to the health care system, or receive the drugs they need for as long as they need them.HIV/AIDS in Minority Communities acknowledges the prevalence of HIV/AIDS within minority communities in the U.S. and strives to educate physicians about the barriers to treatment that exist for minority patients. By analyzing the main causes of treatment failure and promoting respect for individual and cultural values, this book effectively teaches readers to provide responsive, patient-centered care and devise preventive strategies for minority communities. Comprehensive chapters contributed by physicians with extensive experience dealing with HIV/AIDS in minority communities cover issues as far-reaching as: anti-retroviral therapy; dermatologic manifestations and co-morbidities of the disease in patients of color; unique risks to women and MSMs of color; participation of minority cases in HIV research; and substance abuse and mental health issues.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -This book gives you a step-by-step introduction to analysing time series using the open source software R. Each time series model is motivated with practical applications, and is defined in mathematical notation. Once the model has been introduced it is used to generate synthetic data, using R code, and these generated data are then used to estimate its parameters. This sequence enhances understanding of both the time series model and the R function used to fit the model to data. Finally, the model is used to analyse observed data taken from a practical application. By using R, the whole procedure can be reproduced by the reader. All the data sets used in the book are available on the website staff.elena.aut.ac.nz/Paul-Cowpertwait/ts/.The book is written for undergraduate students of mathematics, economics, business and finance, geography, engineering and related disciplines, and postgraduate students who may need to analyse time series as part of their taught programme or their research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Etat : Neu. Neuware -The field of sports medicine covers a tremendous territory. Athletes present to their physician with everything from sprained ankles to bowel problems while running. Many of the classic textbooks in sports medicine cover many of these issues in a cursory way. Two major organ systems that account for many injuries in athletes are the nervous system and the vascular system. Because of their widespread, diffuse nature, athletes can present with myriad signs and symptoms related to these systems. Drs. Akuthota and Herring have done an outstanding job in their textbook Nerve and Vascular Injuries in Sports Medicine to produce a commonsense, yet thorough, approach to potential nerve and vascular injuries in athletes. The text provides any physician or clinician who evaluates and treats athletes with a clear path to an appropriate history, physical examination, imaging studies, and electrophysiologic and vascular examinations of any athlete with potential nerve or vascular injuries. The first third of the book describes the appropriate evaluation of athletes with nerve and vascular symptoms and signs. Emphasis is placed on kinetic chain contributions to nerve and vascular injuries to address not only the cause of the injury but possible associated, contributing biomechanical deficiencies. The last two-thirds of the book cover regional specific nerve and vascular injuries with special attention to stingers, thoracic outlet syndrome, lumbar radiculopathy, and compartment syndromes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Buch. Etat : Neu. Neuware -Health Effects of Cell Phone Radiation will offer a concentrated and up-to-date overview on the effects of radio frequencies on human tissue. While significant advances are being made on many fronts, ranging in frequency from quasi-static to the optical regime, a special emphasis of this volume is on current understanding of biological interactions of cellular mobile communication radiation. The use of cell-phones has experienced phenomenal growth - some estimate that there will be more than 3.5 billion users of these wireless devices by the end of 2010, worldwide.The widespread impact of these new wireless technologies has raised concerns about the safety of human exposure to radio-frequency (RF) energy emitted by these telecommunication devices. A better understanding of the biological effects of RF electromagnetic field is needed to safeguard against possible harm to the general population. Fortunately in recent years there has been a resurgence of research interest in achieving a quantitative understanding of the relationships between the biological effects of RF radiation and the physical variables that may cause them. A significant number of results have and are beginning to appear in the literature. This volume reviews and assesses the biological effects of exposure to electromagnetic fields from wireless communication technology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Buch. Etat : Neu. Neuware -This book provides an introduction to two important aspects of modern bioch- istry, molecular biology, and biophysics: computer simulation and data analysis. My aim is to introduce the tools that will enable students to learn and use some f- damental methods to construct quantitative models of biological mechanisms, both deterministicandwithsomeelementsofrandomness;tolearnhowconceptsofpr- ability can help to understand important features of DNA sequences; and to apply a useful set of statistical methods to analysis of experimental data. The availability of very capable but inexpensive personal computers and software makes it possible to do such work at a much higher level, but in a much easier way, than ever before. TheExecutiveSummaryofthein uential2003reportfromtheNationalAcademy of Sciences, ¿BIO 2010: Transforming Undergraduate Education for Future - search Biologists¿ [12], begins The interplay of the recombinant DNA, instrumentation, and digital revolutions has p- foundly transformed biological research. The con uence of these three innovations has led to important discoveries, such as the mapping of the human genome. How biologists design, perform, and analyze experiments is changing swiftly. Biological concepts and models are becoming more quantitative, and biological research has become critically dependent on concepts and methods drawn from other scienti c disciplines. The connections between the biological sciences and the physical sciences, mathematics, and computer science are rapidly becoming deeper and more extensive.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Buch. Etat : Neu. Neuware -gain-sensitivityproductandthetwo-integratorloop.Chapter7d- cusses coupled forms and signal scaling, and Chapter 8 discusses various methods for immitance simulation. Wave active filters are discussed in v vi Preface Chapter9andleapfrogfiltersinChapter10.Finally,tuningtechniquesare discussedinChapter11. Textwithasmallerfontiseithersolvedexamplesormaterialthatthereader mayskipoverwithoutlosingthemainpoints.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Buch. Etat : Neu. Neuware -Adolescence is typically fraught with problems, even under optimal conditions. And when chronic illness is added to the picture, medical and related social issues can complicate, and even disrupt, the course of development. The first text geared toward the integrated care setting, Behavioral Approaches to Chronic Disease in Adolescence offers clinicians an evidence-based guide to helping their young clients manage their chronic conditions and treating the psychosocial effects¿from school problems and stigma to noncompliance and depression¿that frequently follow diagnosis. Expert contributors present up-to-date information on epidemiology, symptoms, comorbid psychosocial problems, and treatment options for a variety of common illnesses, arranged to foster effective interventions for adolescents and efficient collaboration with other care providers in the team. Coverage is comprehensive, authoritative, and accessible, ensuring best practice while respecting each client¿s individuality: Empirically-based treatment guidelines for illnesses commonly found in youth, including Type 1 and 2 diabetes, asthma, cancer, obesity, and chronic pain. Overview of the physiology of adolescence, particularly as it may be affected by medical conditions, and of adolescent brain development. Latest findings on the role of families in teens¿ adjustment to illness and treatment. Cultural considerations affecting ethnically diverse clients and their families. Detailed discussions of ethical issues relevant to treating chronically ill young people, and of controversies involving pharmacotherapy with this population. Chapters contain useful handouts for clinicians and clients. Taking Care of the Practitioner¿ chapter with helpful strategies for avoiding burnout. Its emphasis on specific practical information makes Behavioral Approaches to Chronic Disease in Adolescence a ¿go-tö reference for health psychologists, child and adolescent mental health practitioners, pediatriciansand family practitioners, and clinical social workers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Buch. Etat : Neu. Neuware -New and unpredicted technologies are emerging at an unprecedented pace around the world. Communication of those new discoveries is occurring faster than ever, meaning that the unique ownership of a piece of new technology is no longer a sufficient position, if not impossible. In today¿s world, recognition of the potential applications of a technology and a sense of purpose in exploiting it are far more important than simply having access to it. Technological surprise has and will continue to take many forms. A plethora of new technologies are under development for peaceful means but may have un- tended security consequences and will certainly require innovative counterme- ures. A relevant example is the tremendous development in biotechnology that has occurred since the advent of recombinant DNA and tissue culture-based processes in the 1970s. If US government agencies and the defense and academic commu- ties had more clearly recognized the potential for biotechnology to affect fun- mental security and warfighting doctrines 20 years ago, the situation today could be very different. Defense against chemical and biological weapons ¿ from both states and nonstate actors ¿ currently presents a threat that is difficult to predict and for which traditional solutions are increasingly less effective. Nanotechnology has emerged as a well-funded discipline that, like biote- nology, carries the potential for groundbreaking applications and the potential for unpredictable harm. The world is likely 20 years away from the full impact of the nanotechnology on defensive capabilities.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 172 pp. Englisch.

Buch. Etat : Neu. Neuware -In studying the past, archaeologists have focused on the material remains of our ancestors. Prehistorians generally have only artifacts to study and rely on the diverse material record for their understanding of past societies and their behavior. Those involved in studying historically documented cultures not only have extensive material remains but also contemporary texts, images, and a range of investigative technologies to enable them to build a broader and more reflexive picture of how past societies, communities, and individuals operated and behaved. Increasingly, historical archaeology refers not to a particular period, place, or a method, but rather an approach that interrogates the tensions between artifacts and texts irrespective of context. In short, historical archaeology provides direct evidence for how humans have shaped the world we live in today.Historical archaeology is a branch of global archaeology that has grown in the last 40 years from its North American base into an increasingly global community of archaeologists each studying their area of the world in a historical context. Where historical archaeology started as part of the study of the post-Columbian societies of the United States and Canada, it has now expanded to interface with the post-medieval archaeologies of Europe and the diverse post-imperial experiences of Africa, Latin America, and Australasia.The 36 essays in the International Handbook of Historical Archaeology have been specially commissioned from the leading researchers in their fields, creating a wide-ranging digest of the increasingly global field of historical archaeology. The volume is divided into two sections, the first reviewing the key themes, issues, and approaches of historical archaeology today, and the second containing a series of case studies charting the development and current state of historical archaeological practice around the world. This key reference work captures the energy and diversity of this global discipline today.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 720 pp. Englisch.

Buch. Etat : Neu. Neuware - Symmetry is a key ingredient in many mathematical, physical, and biological theories. Using representation theory and invariant theory to analyze the symmetries that arise from group actions, and with strong emphasis on the geometry and basic theory of Lie groups and Lie algebras, Symmetry, Representations, and Invariants is a significant reworking of an earlier highly-acclaimed work by the authors. The result is a comprehensive introduction to Lie theory, representation theory, invariant theory, and algebraic groups, in a new presentation that is more accessible to students and includes a broader range of applications.The philosophy of the earlier book is retained, i.e., presenting the principal theorems of representation theory for the classical matrix groups as motivation for the general theory of reductive groups. The wealth of examples and discussion prepares the reader for the complete arguments now given in the general case.Key Features of Symmetry, Representations, and Invariants: (1)Early chapters suitable for honors undergraduate or beginning graduate courses, requiring only linear algebra, basic abstract algebra, and advanced calculus; (2) Applications to geometry (curvature tensors), topology (Jones polynomial via symmetry), and combinatorics (symmetric group and Young tableaux); (3) Self-contained chapters, appendices, comprehensive bibliography; (4) More than 350 exercises (most with detailed hints for solutions) further explore main concepts; (5) Serves as an excellent main text for a one-year course in Lie group theory; (6) Benefits physicists as well as mathematicians as a reference work.

Taschenbuch. Etat : Neu. Neuware -Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care.The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine.Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Buch. Etat : Neu. Neuware -Biomedical Materials provides a comprehensive discussion of contemporary biomaterials research and development. Highlighting important topics associated with Engineering, Medicine and Surgery, this volume reaches a wide scope of professionals, researchers and graduate students involved with biomaterials. A pedagogical writing style and structure provides readers with an understanding of the fundamental concepts necessary to pursue research and industrial work on biomaterials, including characteristics of biomaterials, biological processes, biocompatibility, and applications of biomaterials in implants and medical instruments.Written by leading researchers in the field, this text book takes readers to the forefront of biomedical materials development, providing them with a taste of how the field is changing, while also serving as a useful reference to physicians and engineers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 592 pp. Englisch.

Buch. Etat : Neu. Neuware -This volume contains ve chapters. The topics covered are the cathodic reduction of nitrate, for which the key issues are pr- uct selectivity and current ef ciency; a discussion of ionic l- uids known as molten or fused salts in key industrial processes; the properties of nanowires made of metals and semiconductors by means of electrodeposition into porous templates and template synthesis; and an overview of a range of alloys used in elect- plating, and trends in ammonium electrolysis. Also, included is a review of the applications of synchroton x-ray scattering to the electrochemical interphase. Chapter 1 by Celia Milhano and Derek Pletcher reviews the cathodic reduction of nitrate as a ¿truly fascinating reaction¿ since processes for nitrate removal from drinking water and effluents and reducing nitrates in nuclear waste is an essential step in n- lear waste disposal. The authors also review electrochemical membrane technology not involving the cathodic reduction of - trate. In Chapter 2, the authors discuss substances called ionic l- uids, and the fact that this is really a new more modern term for molten or fused salts. However, the label of ionic liquids is usu- ly applied to the liquid state of salts at or near room temperature, which is a way to differentiate low-melting salts from higher me- ing cousins. These molten or fused salts form the basis of several key industrial processes, and this chapter is primarily devoted to the non-haloaluminate ionic liquids as reviewed by Tetsuya Tsuda and Charles L. Hussey.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Buch. Etat : Neu. Neuware -Knowledge about the outer heliosphere and the interstellar medium, which were long treated as two separate fields, has improved dramatically over the past 25 years as a consequence of recent developments: The discovery of interstellar pickup ions and neutral helium inside the heliosphere, the determination of the interstellar hydrogen distribution in the heliosphere obtained using backscattered solar Lyman-alpha radiation, the prediction and subsequent detection of the hydrogen wall just outside of the heliopause, the development of detailed global models for the interaction of solar wind plasma with the interstellar medium, and most recently, direct in-situ plasma and field measurements inside of the heliosheath. At the same time, our understanding of the nearby galactic environment, including the composition and dynamics of the warm gas clouds and hot gas in the local bubble, has benefited greatly from absorption-line spectroscopy using nearby stars as background sources and dynamic modeling. The present volume provides a synopsis of these developments organised into seven sections: Dominant physical processes in the termination shock and heliosheath, three-dimensional shape and structure of the dynamic heliosphere, relation of the plasmas and dust inside and outside of the heliosphere, origin and properties of the very local interstellar medium, energy and pressure equilibria in the local bubble, physical processes in the multiphase interstellar medium inside of the local bubble, and the roles that magnetic fields play in the outer heliosphere and the local bubble. The last theme is probably the most basic of all as magnetic fields play important roles in most of the phenomena discussed here. The volume concludes with four papers providing the 'big picture' by looking at the time evolution of both the heliosphere and the local bubble, looking beyond the local bubble, and finally addressing the challenges in modeling the interface between the two media.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 484 pp. Englisch.

Buch. Etat : Neu. Neuware -Carbon nanotubes (CNTs) and Boron nitride nanotubes (BNNTs) are part of the so-called B-C-N material system, which includes novel nanostructures of carbon (C), doped-carbon, boron (B), boron nitride (BN), carbon nitride (CNx), boron-carbon nitride (BxCyNz), and boron carbide (BxCy). BNNTs and CNTs are structurally similar and share extraordinary mechanical properties, but they differ in chemical, biological, optical, and electrical properties. Therefore, hybrid nanotubes constructed of B, C, N elements are expected to form a new class of nanotubes with tunable properties between those of CNTs and BNNTs. In addition, these B-C-N nanostructures will further enhance and complement the applications of CNTs and BNNTs. With contributions from leading experts, B-C-N Nanotubes and Related Nanostructures is the first book to cover all theoretical and experimental aspects of this emerging material system, and meets the need for a comprehensive summary of the tremendous advances in research on B-C-N materials in recent years.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Buch. Etat : Neu. Neuware -Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells¿and not the major bulk of the tissue¿that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy.The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.

Buch. Etat : Neu. Neuware -Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trendsfor understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Buch. Etat : Neu. Neuware -Advanced probes and new fabrication techniques enable nanomaterials to pervade multiple disciplines, including physics, chemistry, engineering and biology. Na- materials have been extensively investigated with various kinds of morphologies (nanoparticles, nanowhiskers, nanorods, nanowires, nanoclusters, quantum dots, etc. ) and compositions (semiconductor, metal, polymer, etc. ). Impressive progress has been made on directed assembly and synthesis, structure, and property ch- acterization, as well as nanoscale device concepts and performance by a diverse group of experts. However, in spite of continued advancements in various aspects of functional nanomaterials, numerous challenges must still be overcome at different stages for practical applications to be realized. It seems that there is a need for a book in which individual research groups comprehensively review their up-to-date efforts and simulate further developments in other laboratories. Therefore, I believe that this book, which consists of twelve chapters from nine countries, is a timely undertaking. ¿Fabrication of Oxide Nanoparticles by Ion Implantation and Thermal Oxi- tion¿ is an in-depth review of the formation of oxide nanoparticles by metal ion implantation and subsequent thermal oxidation. Amekura and Kishimoto believe that there is a potential for an ¿embedded¿ breakthrough in the eld of oxide nanoparticles similar to ¿Hache¿s nding of a breakthrough¿ in the eld of metal nanoparticles. In¿DesignofSolution-GrownZnONanostructures¿,Pauporter ¿ eviews signi cant progress toward the growth of well-controlled ZnO nanostructures in solution. He argues that solution-based methods are cost-effective and that the resulting nanostructures are easy to scale up for applications.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 496 pp. Englisch.

Buch. Etat : Neu. Neuware - Random variables are rarely independent in practice and so many multivariate distributions have been proposed in the literature to give a dependence structure for two or more variables. In this book, we restrict ourselves to the bivariate distributions for two reasons: (i) correlation structure and other properties are easier to understand and the joint density plot can be displayed more easily, and (ii) a bivariate distribution can normally be extended to a multivariate one through a vector or matrix representation. This volume is a revision of Chapters 1-17 of the previous book Continuous Bivariate Distributions, Emphasising Applications authored by Drs. Paul Hutchinson and Chin-Diew Lai.The book updates the subject of copulas which have grown immensely during the past two decades. Similarly, conditionally specified distributions and skewed distributions have become important topics of discussion in this area of research. Thisvolume, which provides an up-to-date review of various developments relating to bivariate distributions in general, should be of interest to academics and graduate students, as well as applied researchers in finance, economics, science, engineering and technology.N. BALAKRISHNAN is Professor in the Department of Mathematics and Statistics at McMaster University, Hamilton, Ontario, Canada. He has published numerous research articles in many areas of probability and statistics and has authored a number of books including the four-volume series on Distributions in Statistics, jointly with Norman L. Johnson and S. Kotz, published by Wiley. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and the Editor-in-Chief of Communications in Statistics and the Executive Editor of Journal of Statistical Planning and Inference.CHIN-DIEW LAI holds a Personal Chair in Statistics at Massey University, Palmerston North, New Zealand. He has published more than 100 peer-reviewed research articles and co-authored three well-received books. He was a former editor-in-chief and is now an Associate Editor of the Journal of Applied Mathematics and Decision Sciences.

Buch. Etat : Neu. Neuware - The Proceedings of the 2007National Conference on Environmental Science and Technology contains current and emerging issues and advances in pollution prevention, fate and transport of contaminants, bioremediation, bio-processing, innovative environmental technologies, global climate change, and environmental justice and ethics. Several discussions about these topics among federal environmental agencies, private environmental agencies and university environmental professors set the stage for the 2007 National Conference on Environmental Science and Technology and this book. The purpose of the conference was to address pollution prevention, solutions, and research needs, and foster relationships that could result in partnerships needed to protect and sustain the environment and improve the quality of life.

Buch. Etat : Neu. Neuware - This research program began in 1993. The idea of developing representative samples of those active in the business creation process, now called nascent entrepreneurs, developed from the success of using regional characteristics to 1 predict variations in new firm birth rates in six countries. The initial purpose was to determine those external factors that encouraged individuals to initiate the business creation process and become, as they are now called, nascent entrepreneurs. The research procedures, mainly the critical aspects of the scre- ing procedures, were developed with the Survey Research Laboratory at the University of Wisconsin in Madison to complete the Wisconsin Entrepreneurial 2 Climate Study. Support for an initial test with a national sample was provided by the Institute for Social Research at the University of Michigan. Richard Curtin became involved with the incorporation of the screening module as part 3 of the Survey of Consumers in October and November in 1993. The success of these efforts in providing a detailed description of the ent- preneurial process based on representative samples led to substantial interest among entrepreneurial scholars. A founding team of Nancy Carter, William Gartner, and Paul Reynolds was able to organize the Entrepreneurial Research Consortium (ERC), a collaborative network of 34 research units that shared the financial cost and sweat equity required to implement the first national project, 4 PSED I.

Buch. Etat : Neu. Neuware - In today's world, three great classes of non-infectious diseases - the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders - have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease.The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional detailsintegrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Buch. Etat : Neu. Neuware - It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize this growing knowledge and present all the current studies concerning the basic research of SpA.Over the last decade, enormous progress has been made in the understanding of the molecular and cellular processes that lead to disease pathology. Recognition of the pathways involved in the pathogenic mechanisms of disease and the potential to target specific immune effector functions have opened the door to a wide range of innovative treatment opportunities for the SpA. Thus, we believe that the understanding of the specific molecular mechanisms involved would help to design highly specific drugs in the future. The contributors are among the best in their field and reflect the state of the art of research and current opinion of rheumatologists and immunologists.

Buch. Etat : Neu. Neuware - It is a great honor to be asked to introduce this exciting new volume, having been heavily involved in the first comprehensive synthesis in the early 1980s. Gibbons are the most enthralling of primates. On the one hand, they are the most appealing animals, with their upright posture and body shape, facial markings, dramatic arm-swinging locomotion and suspensory postures, and devastating duets; on the other hand, the small apes are the most diverse, hence biologically valuable and informative, of our closest relatives. It is hard for me to believe that it is 40 years to the month since I first set foot on the Malay Peninsula to start my doctoral study of the siamang. I am very proud to have followed in the footsteps of the great pioneer of primate field study, Clarence Ray Carpenter (CR or Ray, who I was fortunate to meet twice, in Pennsylvania and in Zurich), first in Central America (in 1967) and then in Southeast Asia. It is 75 years since he studied howler monkeys on Barro Colorado Island in the Panama Canal Zone. It is 70 years since he studied the white-handed gibbon in Thailand.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book will be a key trailblazer in a new and upcoming field. The author's predictive approach relies on simple and intuitive probability formulations that will appeal to readers with a modest knowledge of astronomy, mathematics, and statistics. Wells' carefully erected theory stands on a sure footing and thus should serve as the basis of many rational predictions of survival in the face of not only natural disasters such as hits by asteroids or comets, but perhaps more surprisingly from man-made hazards arising from genetic engineering or robotics.Any formula for predicting human survival will invite controversy. Dr Wells counters anticipated criticism with a thorough approach in which four lines of reasoning are used to arrive at the same survival formula. One uses empirical survival statistics for business firms and stage shows. Another is based on uncertainty of risk rates. The third, more abstract, invokes Laplace's principle of insufficient reason and involves an observer's random arrival in the lifetime of the entity (the human race) in question. The fourth uses Bayesian theory.The author carefully explains and gives examples of the conditions under which his principle is valid and provides evidence that can counteract the arguments of critics who would reject it entirely. His deflection of possible criticisms results from two major premises: selecting the proper random variable and 'reference class' to make predictions, and the recognition that if one does not know the law that governs a process, then the best prediction that can be made is his own formula. 240 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -To commemorate the momentous 50th anniversary of Yuri Gagarin's pioneering journey into space on 12th April 2011, a series of five books - to be published annually - will explore this half century, decade by decade, to discover how humanity's knowledge of flying, working and living in space has changed. Each volume will focus not only upon the individual missions within 'its' decade, but also upon the key challenges facing human space exploration at specific points within those 50 years: from the simple problems of breathing and eating in space to the challenges of venturing outside in a pressurised spacesuit and locomotion on the Moon.The first volume of this series will focus upon the 1960s, exploring each mission from April 1961 to April 1971 in depth: from the pioneering Vostok flights to the establishment of the first Salyut space station and from Alan Shepard's modest sub-orbital 'hop' into space to his triumphant arrival at the Moon's Fra Mauro foothills almost a decade later. 512 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -More people in communities of color are contracting, living with, and being treated for HIV/AIDS than ever before. In 2005, 71% of new AIDS cases were diagnosed in people of color. The rate of HIV infection in the African-American community alone has increased from 25% of total cases diagnosed in 1985 to 50% in 2005. Latinos similarly comprise a disproportionate segment of the AIDS epidemic: though they make up only 14% of the U.S. population, 20% of AIDS cases diagnosed in 2004 were Latino/a. Though the number of racial and ethnic minority HIV/AIDS cases continues to grow, the health care community has been unable to adequately meet the unique medical needs of these populations. African-American, Latino/Latina, and other patients of color are less likely to seek medical care, have sufficient access to the health care system, or receive the drugs they need for as long as they need them.HIV/AIDS in Minority Communities acknowledges the prevalence of HIV/AIDS within minority communities in the U.S. and strives to educate physicians about the barriers to treatment that exist for minority patients. By analyzing the main causes of treatment failure and promoting respect for individual and cultural values, this book effectively teaches readers to provide responsive, patient-centered care and devise preventive strategies for minority communities. Comprehensive chapters contributed by physicians with extensive experience dealing with HIV/AIDS in minority communities cover issues as far-reaching as: anti-retroviral therapy; dermatologic manifestations and co-morbidities of the disease in patients of color; unique risks to women and MSMs of color; participation of minority cases in HIV research; and substance abuse and mental health issues. 320 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book gives you a step-by-step introduction to analysing time series using the open source software R. Each time series model is motivated with practical applications, and is defined in mathematical notation. Once the model has been introduced it is used to generate synthetic data, using R code, and these generated data are then used to estimate its parameters. This sequence enhances understanding of both the time series model and the R function used to fit the model to data. Finally, the model is used to analyse observed data taken from a practical application. By using R, the whole procedure can be reproduced by the reader. All the data sets used in the book are available on the website book is written for undergraduate students of mathematics, economics, business and finance, geography, engineering and related disciplines, and postgraduate students who may need to analyse time series as part of their taught programme or their research. 272 pp. Englisch.