springer new york mai 2011 (109 résultats)

Taschenbuch. Etat : Neu. Neuware -Space medicine has been an important component of the success of human spaceflight and will continue to play a critical role in the future ventures. To prepare for the day when astronauts will leave low Earth orbit for long-duration exploration missions, space medicine experts must develop a thorough understanding of the effects of microgravity on the human body, as well as ways of migrating these effects. To gain a complete understanding of the effects of space on the human body and to create the tools and technologies required for successful exploration, space medicine will become an increasingly collaborative discipline incorporating the skills of physicians, biomedical scientists, engineers, and mission planners. In this work, Dr. Erik Seedhouse examines the future of space medicine in relation to human space exploration. He describes what is necessary to keepa crew alive in space, how it will be accomplished in the future, and the medical challenges faced by interplanetary astronauts. The book is divided into three sections. The first looks at space medicine on board the ISS, where astronaut stays are often of long duration. The second section considers the Exploration Class medical dangers, beginning with radiation and the consequent Acute Radiation Syndrome (ARS). The final section looks at future developments and the importance of telemedicine and how revolutionary technologies will protect interplanetary astronauts from the space environment. The book ends with a description of the kind of hibernation necessary to insure the well being of interplanetary astronauts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

Buch. Etat : Neu. Neuware -Krantz takes the reader on a journey around the globe and through centuries of history , exploring the many transformations that mathematical proof has undergone from its inception at the time of Euclid and Pythagoras to its versatile, present-day use . The author elaborates on the beauty, challenges and metamorphisms of thought that have accompanied the search for truth through proof.The first two chapters examine the early beginnings of concept of proof and the creation of its elegant structure and language, touching on some of the logic and philosophy behind these developments. The history then unfolds as the author explains the changing face of proofs. The more well-known proofs , the mathematicians behind them, and the world that surrounded them are all highlighted . Each story has its own unique past; there was often a philosophical, sociological, technological or competitive edge that restricted or promoted progress. But the author's commentary and insights create a seamless thread throughout the many vignettes.Though there are many truths to be discovered in this book, by the end it is clear that there is no formalized approach or standard method of discovery to date. This is shown in noting some of the more prominent discussions currently underway, such as Gorenstein's effort to classify finance groups, Thomas Hale's resolution of the Kepler sphere-packing problem, and other modern tales. Most of the proofs are discussed in detail with figures and some equations accompanying them, allowing both the professional mathematician and those less familiar with mathematics to derive the same joy from reading this book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Books on time series models deal mainly with models based on Box-Jenkins methodology which is generally represented by autoregressive integrated moving average models or some nonlinear extensions of these models, such as generalized autoregressive conditional heteroscedasticity models. Statistical inference for these models is well developed and commonly used in practical applications, due also to statistical packages containing time series analysis parts. The present book is based on regression models used for time series. These models are used not only for modeling mean values of observed time se ries, but also for modeling their covariance functions which are often given parametrically. Thus for a given finite length observation of a time series we can write the regression model in which the mean value vectors depend on regression parameters and the covariance matrices of the observation depend on variance-covariance parameters. Both these dependences can be linear or nonlinear. The aim of this book is to give an unified approach to the solution of statistical problems for such time series models, and mainly to problems of the estimation of unknown parameters of models and to problems of the prediction of time series modeled by regression models.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -In the period since the first edition was published, I have appreciated the corre spondence from all parts of the world expressing thanks for the presentation of statistics from a user's perspective. It has been particularIy pleasing to have been invited to contribute to course restructuring and development based on the ap proach to learning and applying statistics that underlies this book. In addition, I have taken account of suggestions and criticisms, and I hope that this new edition will address all major concerns. The range of readily accessible statistical methods has greatly expanded over the past decade, particularly with the growing accessibility of comprehensive statisti cal computing packages. The approach adopted in this book has anticipated the changes by its emphasis on building understanding and skills in method selection and interpretation of findings. There has been a reduction in computational for mulas to reflect the fact that basic statistical analyses are now almost universally undertaken on computers. This has allowed the inclusion of a more general cover age of unifying methodology, particularly Generalized linear methodology, which permits users to more accurately match their requirements to statistical models and methods. A major addition is a chapter on the commonly used multivariate methods.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 672 pp. Englisch.

Buch. Etat : Neu. Neuware - Offers a unique combination of informative text, magnificent illustrations and stylish design Examines the 100 most important discoveries since the invention of the telescope Features spectacular photographs, taken with the largest telescopes on Earth and in space, that portray distant corners of the universe Author Govert Schilling is a renowned astronomy journalist and science communicator In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. Doing what Schilling does best, he takes the reader on an adventure through both space and time. Photographs and amazing pictures line the pages of this book, offering the reader an escape from this world and an invitation to a world far beyond what the unaided human eye can detect.

Taschenbuch. Etat : Neu. Neuware -Higher-Dimensional Algebraic Geometry studies the classification theory of algebraic varieties. This very active area of research is still developing, but an amazing quantity of knowledge has accumulated over the past twenty years. The author's goal is to provide an easily accessible introduction to the subject.The book covers in the beginning preparatory and standard definitions and results, moves on to discuss various aspects of the geometry of smooth projective varieties with many rational curves, and finishes in taking the first steps towards Mori's minimal model program of classification of algebraic varieties by proving the cone and contraction theorems.The book is well-organized and the author has kept the number of concepts that are used but not proved to a minimum to provide a mostly self-contained introduction to graduate students and researchers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -The Journey Ahead At the heart of transcendental number theory lies an intriguing paradox: While essen tially all numbers are transcendental, establishing the transcendence of a particular number is a monumental task. Thus transcendental numbers are an enigmatic species of number: We know they are all around us and yet it requires enormous effort to catch one. More often than not, they slip through our fingers and dissappear back into the dense jungle of numbers. Here we will venture to tame a few of these incredible creatures. In the pages ahead we offer an approach to transcendence that not only includes the intricate analysis but also the beautiful ideas behind the technical details. The phrase 'classical transcendental number theory' in the title of this book refers to the most widely known results that were obtained in the nineteenth and early twentieth centuries. The reason for this focus is threefold. Firstly, this body of work requires only the mathematical techniques and tools familiar to advanced undergraduate mathematics students, and thus this area can be appreciated by a wide range of readers. Secondly, the ideas behind modem transcendence results are almost always an elaboration of the classical arguments we will explore here. And finally, and perhaps more importantly, this early work yields the transcendence of such admired and well-known numbers as e, rr, and even 2v'2.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 276 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -The guiding principle in this book is to use differential forms as an aid in exploring some of the less digestible aspects of algebraic topology. Accord ingly, we move primarily in the realm of smooth manifolds and use the de Rham theory as a prototype of all of cohomology. For applications to homotopy theory we also discuss by way of analogy cohomology with arbitrary coefficients. Although we have in mind an audience with prior exposure to algebraic or differential topology, for the most part a good knowledge of linear algebra, advanced calculus, and point-set topology should suffice. Some acquaintance with manifolds, simplicial complexes, singular homology and cohomology, and homotopy groups is helpful, but not really necessary. Within the text itself we have stated with care the more advanced results that are needed, so that a mathematically mature reader who accepts these background materials on faith should be able to read the entire book with the minimal prerequisites. There aremore materials here than can be reasonably covered in a one-semester course. Certain sections may be omitted at first reading with out loss of continuity. We have indicated these in the schematic diagram that follows. This book is not intended to be foundational; rather, it is only meant to open some of the doors to the formidable edifice of modern algebraic topology. We offer it in the hope that such an informal account of the subject at a semi-introductory level fills a gap in the literature.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware - The present dire economic environment has greatly affected business and the opportunities for advancement or even holding a job. Even universities, although not directly in business, are feeling the impact of diminishing endowments, resulting in lower disposable funds and reduction in innovative, unproven programs, which, in the past, often led to breakthroughs. These conditions we hope are only temporary, and they will not affect careers in the long run.This book is written to guide the reader on how to progress in his or her chosen career, how to reach a high position in which one is actually in charge of a unit, department, school, or business and how to run it successfully.

Buch. Etat : Neu. Neuware -The central aim of the Sunrise project is to understand the structure and dynamics of the magnetic field in the solar atmosphere. The magnetic field is the source of solar activity, controls the space environment of the Earth and causes the variability of solar irradiance, which may be a significant driver of long-term changes of the terrestrial climate. Interacting with the convective plasma flow, the magnetic field in the solar photosphere develops intense field concentrations on scales below 100 km, which are crucial for the dynamics and energetics of the whole solar atmosphere. These spatial scales cannot be studied systematically from the ground because of image distortions due to atmospheric turbulence. The balloon-borne Sunrise telescope has, for the first time, provided measurements of the magnetic structure of the solar atmosphere on its intrinsic spatial and temporal scales. The book gives an overview about the instrumentation and the successful flight in 2009.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 128 pp. Englisch.

Buch. Etat : Neu. Neuware -Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial rejuvenatin it has untapped potential. The current state of PDT therapy and future applications are discussed in detail in this exciting new volume. Throughout, the focus is on evidence-based clinical uses of PDT, including pretreatment regimens, avoidance and management of complications, and posttreatment suggestions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 216 pp. Englisch.

Buch. Etat : Neu. Neuware -The book introduces the solar coronal mass ejection phenomena. This includes both those observed in the corona and those further from the Sun, known as interplanetary coronal mass ejections. We discuss the history and physics behind these phenomena, theories describing their launch and evolution, association with other solar eruptive phenomena, and methods employed for their detection and scientific data extraction. Instruments used for their study (past, present and future) are also discussed, along with their resulting space weather effectson Earth and other planets. The latter requires a description of the Earth¿s magnetosphere, which is also included. Coronal Mass Ejections brings together solar physics, heliospheric physics, and magnetospheric physics, three traditionally separate fields of study. The content is accessible to beginning graduate students who are trying to master difficult fundamental concepts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

Buch. Etat : Neu. Neuware -Based on an EU workshop at the end of 2005, the book discusses risk and our food supply. The introductory chapter will discuss all aspects of risk and how it applies to food, from risk classification to risk management. Following a discussion of risk, the authors will present three different case studies that will emphasize the following issues:¿ What do we want as individuals, as a society¿ What is the political context of the risk discussion¿ When do we act and what are the costs of not acting/acting¿ International trade and legal issues¿ Moral dimensions of decision making¿ How do we deal with the disproportionate 'power' of the various stakeholders¿ Rationality/emotive aspects of argumentation (connection between perception /live experiences, knowledge)¿ What are facts- and do they change with time¿ Psychological aspects: rapture of trust; the need for certainty; connection between danger, fear and riskSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 160 pp. Englisch.

Buch. Etat : Neu. Neuware -The Indian National Science Academy was established in January 1935 with the objective of promoting science in India and harnessing scientific knowledge for the cause of humanity and national welfare. In 1968 it was designated as the adhering organisation in India to the International Council for Scientific Union (ICSU) on behalf of the Government of India. Over the years, the Academy has published a number of journals, volumes, biographical memoirs, etc. The year 2009¿2010 will be specially celebrated to mark the Platinum Jubilee of the Academy. Many programmes are planned in different centres in India on this occasion. In addition, the Academy has decided to publish a number of special volumes on different s- jects ranging from earth sciences to life sciences. This volume is on Physics and Chemistry of the Earth¿s Interior. One of the main objectives of geophysicists is to establish the internal structure of the earth as revealed by seismic tomography. It is also their primary goal to correlate geophy- cal data to reveal thermal and chemical state of the crust, mantle and core of the earth. In - der to interpret seismic velocities and associated density and elastic properties in terms of mineralogical and petrological models of the earth¿s interior, thermodynamic and hi- pressure temperature data from mineral physics are essential. With the advent of different types of multi-anvil and laser-heated diamond anvil equipment, it is now possible to simulate conditions prevalent even in the lower mantle and core of the earth.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Closely paralleling the history of psychology is the history of its critics, their theories, and their contributions. The Critique of Psychology is the first book to trace this alternate history, from a unique perspective that complements the many existing empirical, theoretical, and social histories of the field.Thomas Teo cogently synthesizes major historical and theoretical narratives to describe two centuries of challenges töand the reactions of¿the mainstream. Some of these critiques of content, methodology, relevance, and philosophical worldview have actually influenced and become integrated into the canon; others pose moral questions still under debate. All are accessibly presented so that readers may judge their value for themselves: Kant¿s critique of rational and empirical psychology at the end of the 18th century The natural-scientific critique of philosophical psychology in the 19th century The human-scientific critique of natural-scientific psychology The Marxist traditions of critique Feminist and postmodern critiques and the contemporary mainstream Postcolonial critiques and the shift from cross-cultural to multicultural psychologyThis is not a book of critique for critique¿s sake: Teo defines the field as a work in progress with goals that are evolving yet constant. In emphasizing ethical and political questions faced by psychology as a discipline, this visionary book points students, academics, and practitioners toward new possibilities for their shared future.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Etat : Neu. Neuware -Behavioral and technological innovation has a special place in the future of graduate and medical education, both for students and for educators. A new multi-media pedagogy offers innovative techniques and technologies, drawing widely upon behavioral science.The psychology of multi-media education maximizes learning by involving many different sensory modalities. Although multi-media has long meant use of film and other electronic modality adjuncts like Powerpoint, newer technologies expand these horizons further. Now multi-media pedagogy means not only newer technologies, but also newer, and different education techniques. This book describes psychology innovation currently making educational settings competent and competitive.Student choice rules in education today. The technologically driven environment produces students whose preference is incumbent on electronic research means. Besides using these tools themselves, students thirst for multi-media pedagogy in the classroom online and on campus. It is therefore teachers who close the digital divide between generations in order to educate effectively. Approaches using new technologies and techniques have proven successful internationally with diverse audiences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 92 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Develops a unified mathematical framework for treating a wide variety of diffusion-related periodic phenomena in such areas as heat transfer, electrical conduction, and light scattering. Deriving and using Green functions in one and higher dimensions to provide a unified approach, the author develops the properties of diffusion-wave fields first for the well-studied case of thermal-wave fields and then applies the methods to nonthermal fields.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 756 pp. Englisch.

Buch. Etat : Neu. Neuware -A ground-breaking new volume and the first of its kind to concisely outline and explicate the emerging field of whole person care process, Whole Person Care: A New Paradigm for the 21st Century organizes the disparate strains of literature on the topic. It does so by clarifying the concept of 'whole person' and also by outlining the challenges and opportunities that death anxiety poses to the practice of whole person care. Whole person care seeks to study, understand and promote the role of health care in relieving suffering and promoting healing in acute and chronic illness as a complement to the disease focus of biomedicine. The focus is on the whole person -- physical, emotional, social, and spiritual. Using concise, easy-to-read language, the early chapters offer practitioners a thorough understanding of the concepts, skills and tools necessary for the practice of whole person care from a clinician-patient interaction standpoint, while the last two chapters review the myriad implications of whole person care for medical practice. An invaluable resource for all areas of medical practice and for practitioners at all stages of development, from medical students to physicians and allied health providers with many years of experience, Whole Person Care: A New Paradigm for the 21st Century will have a profound impact on western medical practice in North America and elsewhere.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -In the past three decades, great progress has been made in the theory and prac tice of financial derivative securities. Now huge volumes of financial derivative securities are traded on the market every day. This causes a big demand for experts who know how to price financial derivative securities. This book is designed as a textbook for graduate students in a mathematical finance pro gram and as a reference book for the people who already work in this field. We hope that a person who has studied this book and who knows how to write codes for engineering computation can handle the business of providing efficient derivative-pricing codes. In order for this book to be used by various people, the prerequisites to study the majority of this book are multivariable calculus, linear algebra, and basic probability and statistics. In this book, the determination of the prices of financial derivative secu rities is reduced to solving partial differential equation problems, i. e. , a PDE approach is adopted in order to find the price of a derivative security. This book is divided into two parts. In the first part, we discuss how to establish the corresponding partial differential equations and find the final and nec essary boundary conditions for a specific derivative product. If possible, we derive its explicit solution and describe some properties of the solution. In many cases, no explicit solution has been found so far.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 532 pp. Englisch.

Buch. Etat : Neu. Neuware -This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow¿s SoC designs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Etat : Neu. Neuware -Health has been conceptualized by world and national health organizations (WHO, CDC, Healthy People 2010) as more than the absence of disease. It involves a focus on physical, psychosocial, and functional aspects of life as well as the prevention of future illnesses. At this point in the development of quality health care for cancer survivors, there is sufficient knowledge and expert opinion to push efforts forward to improve the health of cancer survivors. Clearly there is more research in the most prevalent forms of cancers (e.g., breast cancer) than others that provide us with guidance on how to optimize their health, but there are data on other forms of cancers that can also better inform practice. There may also be general care practices that can cut across cancer types. There has been an emergence of epidemiological and clinical research in cancer survivors that can form the basis for a revolution in the quality and nature of health care that survivors receive. This book not only provides the reader with diverse perspectives and data but also integrates this information so it can serve as the foundation necessary to improve and maintain the health of cancer survivors.Reporting of symptoms to health care providers is a complex, multi-determined problem influenced not only by the pathophysiology but also, as we have learned over the years through pain research, by societal, cultural, and biobehavioral factors. This book will consider this important aspect of follow-up for millions of cancer survivors because of the strong reliance on symptom reporting for clinical decision making. In order for us to generate meaningful and effective treatment, we need to better understand the symptom experience in cancer survivors. This book provides much information that will assist us to better understand and manage this complicated end point. The presenting problems need to be articulated and ¿conceptualized¿ as clearly as possible by both parties soappropriate actions can be taken. Since health care costs are a major concern for patients, payers, and providers, this area will also be addressed in all the relevant sections.In taking an interdisciplinary perspective, this book illustrates the importance of a team approach to the improvement of health care and associated health, well-being, and functioning in cancer survivors. The 17 chapters cover critical topics of which physicians and providers of all types must be aware in order to provide the most comprehensive and responsive care for cancer survivors. All of the clinical care chapters include case studies to illustrate the real-world application of these approaches in cancer survivors. Information about sources of referral both within and outside the traditional health care communities will be provided in tabular form. There is no other text that provides both an overview of the problems and their challenges, case illustrations of direct application, and the reality of reimbursement for such care. The editors hope that there may be no need for the clinician or the survivor to adapt to a ¿new normal¿ if the presenting problems are understood and handled from an interdisciplinary perspective as outlined here.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch.

Buch. Etat : Neu. Neuware -Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Etat : Neu. Neuware -The study of the brain and behavior is illuminated with the discovery of invariances.Experimental brain research uncovers constancies amidst variation, with respect to interventions and transformations prescribed by experimental paradigms.Place cells, mirror neurons, event related potentials and areas differentially active in fMRI, all illustrate the pervasive role of invariances in neural systems in relation to their function.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 328 pp. Englisch.

Buch. Etat : Neu. Neuware -The purpose of this text is to provide not only the science and current knowledge of pediatric pain management but a rationale for intervention. The book is ground-breaking in that it provides pearls for the recognition and management of multiple childhood chronic pain syndromes. Also, uncommon yet confounding issues such as pain management for epidermolysis bullosa are adequately addressed. Concerns unique to pediatric patients are reviewed. While there are no firm standards in pediatric chronic pain, a care plan is offered to help guide practitioners when possible.The book will consist of 24 chapters, many co-written by a physician and a psychologist. Chapter 1 covers the history of pediatric chronic pain, the advancement pediatric pain as a clinical subspecialty, development of pediatric pain clinics, and characterization of the common pain syndromes. Chapters 2-4 cover, respectively, the research on early pain exposure and neuroplasticity, theories on the common adolescent pain syndromes, and the demographics of chronic pain in children. Chapters 5-16 discuss approaches to assessment and intervention for specific pediatric and adolescent pain syndromes. Chapters 17-23 address interventional techniques such as therapeutic blocks, neurablation, implantable systems, physical therapy, complementary therapy, and pharmacology including opioid tolerance. The final chapter discusses the role of the nurse practitioner in pediatric chronic pain.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.

Taschenbuch. Etat : Neu. Neuware -During the last decades, there has been an explosion in computation and information technology. This development comes with an expansion of complex observational studies and clinical trials in a variety of fields such as medicine, biology, epidemiology, sociology, and economics among many others, which involve collection of large amounts of data on subjects or organisms over time. The goal of such studies can be formulated as estimation of a finite dimensional parameter of the population distribution corresponding to the observed time- dependent process. Such estimation problems arise in survival analysis, causal inference and regression analysis. This book provides a fundamental statistical framework for the analysis of complex longitudinal data. It provides the first comprehensive description of optimal estimation techniques based on time-dependent data structures subject to informative censoring and treatment assignment in so called semiparametric models. Semiparametric models are particularly attractive since they allow the presence of large unmodeled nuisance parameters. These techniques include estimation of regression parameters in the familiar (multivariate) generalized linear regression and multiplicative intensity models. They go beyond standard statistical approaches by incorporating all the observed data to allow for informative censoring, to obtain maximal efficiency, and by developing estimators of causal effects. It can be used to teach masters and Ph.D. students in biostatistics and statistics and is suitable for researchers in statistics with a strong interest in the analysis of complex longitudinal data.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 412 pp. Englisch.

Buch. Etat : Neu. Neuware -This authoritative book provides state-of-the-art practices and new developments in the imaging of cartilage, associated pathologies, and repair procedures. With a main focus on MRI, major advances in cartilage imaging are put into clinical context relevant for radiologists, rheumatologists, and orthopedic surgeons. International experts provide their insights on cartilage pathologies associated with such conditions as osteoarthritis, osteochondral trauma, and cartilage repair.Morphological MRI techniques are outlined, including new sequences and high field imaging. Molecular imaging techniques able to characterize the biochemical composition of the cartilage matrix are discussed, such as T2 relaxation time, T1rho, and dGEMRIC methods.The first book of its kind, Cartilage Imaging: Significance, Techniques, and New Developments encompasses the full scope of knowledge in this rapidly evolving field. Identifying key techniques for characterizing disease processes as wellas objectively and quantitatively evaluating the results of therapy, this outstanding resource is of benefit to all physicians interested in assessing cartilage disease and repair.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Buch. Etat : Neu. Neuware -Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

Buch. Etat : Neu. Neuware -This book explores the remarkable connections between two domains that, a priori, seem unrelated: Random matrices (together with associated random processes) and integrable systems. The relations between random matrix models and the theory of classical integrable systems have long been studied. These appear mainly in the deformation theory, when parameters characterizing the measures or the domain of localization of the eigenvalues are varied. The resulting differential equations determining the partition function and correlation functions are, remarkably, of the same type as certain equations appearing in the theory of integrable systems. They may be analyzed effectively through methods based upon the Riemann-Hilbert problem of analytic function theory and by related approaches to the study of nonlinear asymptotics in the large N limit. Associated with studies of matrix models are certain stochastic processes, the 'Dyson processes', and their continuum diffusion limits, which govern the spectrum in random matrix ensembles, and may also be studied by related methods.Random Matrices, Random Processes and Integrable Systems provides an in-depth examination of random matrices with applications over a vast variety of domains, including multivariate statistics, random growth models, and many others. Leaders in the field apply the theory of integrable systems to the solution of fundamental problems in random systems and processes using an interdisciplinary approach that sheds new light on a dynamic topic of current research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 544 pp. Englisch.

Buch. Etat : Neu. Neuware -High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.