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  • Robert P. Hawkins

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306460815 ISBN 13 : 9780306460814

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Here is an efficient guide to measuring and graphing behavioral outcomes, and letting the results influence clinical decisions. The authors, all clinical psychologists, describe how the `continuous' measurement of outcomes can document clinical results and provide practical methods for clinicians to routinely get and use credible, precise data. They provide numerous clinical examples that illustrate how behavioral health outcomes can be measured directly and simply. 208 pp. Englisch.

  • Gustaaf De Monie

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384318 ISBN 13 : 9780792384311

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 106,99

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -PROF. DR. anus PEETERS PRESIDENT- ExECUTIVE DIRECTOR, POLICY RESEARCH CORPORATION N. V. The 'Strategies for Global and Regional Ports' confirms that container shipping in the wider Caribbean is in for tumultuous development in the years to come. One of the driving forces behind the momentous changes expected in the provision of maritime liner services in the region, is the growing reliance by major container carriers on multi-layered transhipment concepts and hub ports. Given its favourable location at the junction of North-South and East West trades, the Caribbean region is increasingly becoming a crucial factor in the service pattern of major carriers. As a result, global terminal operating companies such as Hutchison Port Holdings and Stevedoring Services of America, are already tapping the potential for developing port activity that was, until recently, dormant. In anticipation of the new shipping patterns to emerge in the coming months and years, major political decisions with respect to shipping and port development need to be taken by Caribbean Governments. Many of these decisions will be made under pressure of well meaning lobbies, but which do not always have the necessary insight into liner shipping developments. The Netherlands Antilles is one of those nations whose ports are at a crossroads and may either become regional hub ports or turn into feeder ports. In view of the changes in the Caribbean maritime geography, the Ministry of Traffic and Transport of the Netherlands Antilles commissioned Policy Research Corporation N. 252 pp. Englisch.

  • Fuad T. Aleskerov

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384512 ISBN 13 : 9780792384519

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aggregation of individual opinions into a social decision is a problem widely observed in everyday life. For centuries people tried to invent the `best' aggregation rule. In 1951 young American scientist and future Nobel Prize winner Kenneth Arrow formulated the problem in an axiomatic way, i.e., he specified a set of axioms which every reasonable aggregation rule has to satisfy, and obtained that these axioms are inconsistent. This result, often called Arrow's Paradox or General Impossibility Theorem, had become a cornerstone of social choice theory. The main condition used by Arrow was his famous Independence of Irrelevant Alternatives. This very condition pre-defines the `local' treatment of the alternatives (or pairs of alternatives, or sets of alternatives, etc.) in aggregation procedures. Remaining within the framework of the axiomatic approach and based on the consideration of local rules, Arrovian Aggregation Models investigates three formulations of the aggregation problem according to the form in which the individual opinions about the alternatives are defined, as well as to the form of desired social decision. In other words, we study three aggregation models. What is common between them is that in all models some analogue of the Independence of Irrelevant Alternatives condition is used, which is why we call these models Arrovian aggregation models. Chapter 1 presents a general description of the problem of axiomatic synthesis of local rules, and introduces problem formulations for various versions of formalization of individual opinions and collective decision. Chapter 2 formalizes precisely the notion of `rationality' of individual opinions and social decision. Chapter 3 deals with the aggregation model for the case of individual opinions and social decisions formalized as binary relations. Chapter 4 deals with Functional Aggregation Rules which transform into a social choice function individual opinions defined as choice functions. Chapter 5 considers another model &endash; Social Choice Correspondences when the individual opinions are formalized as binary relations, and the collective decision is looked for as a choice function. Several new classes of rules are introduced and analyzed. 260 pp. Englisch.

  • Marian Kryszewski

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306418029 ISBN 13 : 9780306418020

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The subject of this book is stochastic partial differential equations, in particular, reaction-diffusion equations, Burgers and Navier-Stokes equations and the corresponding Kolmogorov equations. For each case the transition semigroup is considered and irreducibility, the strong Feller property, and invariant measures are investigated. Moreover, it is proved that the exponential functions provide a core for the infinitesimal generator. As a consequence, it is possible to study Sobolev spaces with respect to invariant measures and to prove a basic formula of integration by parts (the so-called 'carré du champs identity'. Several results were proved by the author and his collaborators and appear in book form for the first time. Presenting the basic elements of the theory in a simple and compact way, the book covers a one-year course directed to graduate students in mathematics or physics. The only prerequisites are basic probability (including finite dimensional stochastic differential equations), basic functional analysis and some elements of the theory of partial differential equations. 302 pp. Englisch.

  • Jim Stewart

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384334 ISBN 13 : 9780792384335

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 117,69

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book deals with the role of the State in pension provision as an employer, regulator and provider. Part I deals with problems and reforms of public sector pension systems in OECD countries. The countries covered are Denmark, Finland, Germany, The Netherlands, Norway, and the USA. Part II considers the regulation of occupational pension schemes in The Netherlands and the United Kingdom, and whether there is still a role for the State in providing earnings-related pensions in the United Kingdom. Part III presents demographic projections for the next half-century, using Ireland as an example, looks at some of the options which have been used in Finland, and proposed in the United States, to cope with population ageing, and examines issues of intergenerational equity which are posed by these options. All the chapters deal with recent reforms. The chapters are written by acknowledged experts in their field who are independent of both the pensions industry and Government. Hence the chapters provide an informed critical account of current developments in relation to the reform of occupational pension schemes in the public sector and of the debate about the State's role as a regulator of private pension schemes and a provider of pensions based on the social insurance principal. The book is important as a source of information about pension schemes in OECD countries. It shows that there is not a unique model of occupational pension provision for public sector employees and that the pension benefits which are provided in different countries are quite variable. It also shows that public sector occupational pension systems have changed and are in the process of considerable further change in a number of OECD countries. 180 pp. Englisch.

  • Keisuke Iida

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384598 ISBN 13 : 9780792384595

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -International Monetary Cooperation among the United States, Japan, and Germany offers a first - and overdue - book- length study of counterproductive cooperation. It takes to task the critical importance of conducting systematic theory-guided empirical research to examine the validity of arguments that international monetary cooperation could be highly counterproductive. This book combines various methods - formal, quantitative, and qualitative - to study the theories of counterproductive monetary cooperation by focusing on the cooperative episodes among the major industrial countries - the United States, Japan, and Germany. For the first time, this book presents all theories of counterproductive cooperation in one place, subjects them to systematic, empirical scrutiny in the light of the experience of G-3 (U.S., Germany, and Japanese) cooperation since the 1970s, and suggests policy recommendations in the light of the findings. 132 pp. Englisch.

  • Paul R. Mullins

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306460890 ISBN 13 : 9780306460890

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 139,09

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An archaeological analysis of the centrality of race and racism in American culture. Using a broad range of material, historical, and ethnographic resources from Annapolis, Maryland, during the period 1850 to 1930, the author probes distinctive African-American consumption patterns and examines how those patterns resisted the racist assumptions of the dominant culture while also attempting to demonstrate African-Americans' suitability to full citizenship privileges. 236 pp. Englisch.

  • Gerald B. Sheblé

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 079238475X ISBN 13 : 9780792384755

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 160,49

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -`Electric energy must be treated as a commodity which can be bought, sold, and traded, taking into account its time- and space-varying values and costs.` Spot Pricing of Electricity, Schweppe et al, 1988. Computational Auction Mechanisms for Restructured Power Industry Operation outlines the application of auction methods for all aspects of power system operation, primarily for a competitive environment. A complete description of the industry structure as well as the various markets now being formed is given. A thorough introduction to auction basics is included to explain how auctions have grown in other industries. Auction methods are compared to classical techniques for power system analysis, operations, and planning. The traditional applications of economic dispatch, optimal power flow and unit commitment are compared to auction mechanisms. Algorithms for auctions using linearized power flow equations, DC power flow equations, and AC power flow equations are included. The bundling of supportive services, known as ancillary services within the United States, is discussed. Extensions to the basic auction algorithms for inclusion of supportive services as well as algorithms for scheduling and bidding on generation for GENCOs or independent power producers are presented. Algorithms for scheduling and contracting with customers are also presented for energy service companies. An introduction to the various commodity and financial market products includes the use of futures and options for GENCOs. The material is useful for students performing research on the new business environment based on competition. Regulators will find information on initial methods of designing and evaluating market systems, and power exchange and financial analysts will find information on the interdependence of markets and power system-based techniques for risk management. This information compares the new business environment solutions with old business environment solutions. Computational Auction Mechanisms for Restructured Power Industry Operation provides a first introduction to how electricity will be traded as a commodity in the future. 356 pp. Englisch.

  • John Mills

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306461072 ISBN 13 : 9780306461071

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientists and clinicians attending the last 'New Directions in Antiviral Therapy' conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since. Two new classes of antiretrovirals have been licensed, the second-site RT inhibitors and the protease inhibitors; the long in cubation period of active HIV infection, when the infection is clinically latent, is now un derstood to be a period of intense viral replication and turnover of CD4 lymphocytes; measurements of HI V RNA concentration in plasma have been shown to be essential tools for monitoring the course of HIV infection, deciding when to treat, and assessing the re sults of treatment; and finally, combinations of antiretrovirals, particularly combinations including protease inhibitors, have been shown to have dramatically beneficial effects on patients with HIV infection. These advances, coupled with new drugs for the management of herpesvirus infections, have made dramatic differences in the quality and length of life of HIV-infected patients. Additional advances have been made since 1994 in the prevention or management of influenza virus (zanamavir), respiratory syncytial virus (palvizumab), hepatitis B virus (lamivudine and famciclovir), and enterovirus infections (pleconaril). It is difficult to re member that only slightly more than a decade ago there were only a handful of antiviral agents available (none of which were antiretrovirals), and a number of those were either highly toxic, of dubious efficacy, or both. 282 pp. Englisch.

  • Robert P. Hawkins

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306460807 ISBN 13 : 9780306460807

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Here is an efficient guide to measuring and graphing behavioral outcomes, and letting the results influence clinical decisions. The authors, all clinical psychologists, describe how the `continuous' measurement of outcomes can document clinical results and provide practical methods for clinicians to routinely get and use credible, precise data. They provide numerous clinical examples that illustrate how behavioral health outcomes can be measured directly and simply. 212 pp. Englisch.

  • Arno Kunzmann

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384768 ISBN 13 : 9780792384762

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 165,80

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Reuse Techniques for VLSI Design is a reflection on the current state of the art in design reuse for microelectronic systems. To that end, it is the first book to garner the input of leading experts from both research and application areas. These experts document herein not only their more mature approaches, but also their latest research results. Firstly, it sets out the background and support from international organisations that enforce System-on-a-Chip (SoC) design by reuse- oriented methodologies. This overview is followed by a number of technical presentations covering different requirements of the reuse domain. These are presented from different points of view, i.e., IP provider, IP user, designer, isolated reuse, intra-company or inter-company reuse. More general systems or case studies, e.g., metrics, are followed by comprehensive reuse systems, e.g., reuse management systems partly including business models. Since design reuse must not be restricted to digital components, mixed- signal and analog reuse approaches are also presented. In parallel to the digital domain, this area covers research in reuse database design. Design verification and legal aspects are two important topics that are closely related to the realization of design reuse. These hot topics are covered by presentations that finalize the survey of outstanding research, development and application of design reuse for SoC design. Reuse Techniques for VLSI Design is an invaluable reference for researchers and engineers involved in VLSI/ASIC design. 172 pp. Englisch.

  • Swapnajit Mittra

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384776 ISBN 13 : 9780792384779

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 171,19

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Principles of Verilog PLI is a `how to do' text on Verilog Programming Language Interface. The primary focus of the book is on how to use PLI for problem solving. Both PLI 1.0 and PLI 2.0 are covered. Particular emphasis has been put on adopting a generic step-by-step approach to create a fully functional PLI code. Numerous examples were carefully selected so that a variety of problems can be solved through ther use. A separate chapter on Bus Functional Model (BFM), one of the most widely used commercial applications of PLI, is included. Principles of Verilog PLI is written for the professional engineer who uses Verilog for ASIC design and verification. Principles of Verilog PLI will be also of interest to students who are learning Verilog. 404 pp. Englisch.

  • Paul Grefen

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384148 ISBN 13 : 9780792384144

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 192,55

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Database Support for Workflow Management: The WIDE Project presents the results of the ESPRIT WIDE project on advanced database support for workflow management. The book discusses the state of the art in combining database management and workflow management technology, especially in the areas of transaction and exception management. This technology is complemented by a high-level conceptual workflow model and associated workflow application design methodology. In WIDE, advanced base technology is applied, like a distributed computing model based on the corba standard. The usability of the WIDE approach is documented in this book by a discussion of two real-world applications from the insurance and health care domains. Database Support for Workflow Management: The WIDE Project serves as an excellent reference, and may be used for advanced courses on database and workflow management systems. 300 pp. Englisch.

  • Jacques Janssen

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306423626 ISBN 13 : 9780306423628

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 192,55

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is the result of the International Symposium on Semi Markov Processes and their Applications held on June 4-7, 1984 at the Universite Libre de Bruxelles with the help of the FNRS (Fonds National de la Recherche Scientifique, Belgium), the Ministere de l'Education Nationale (Belgium) and the Bernoulli Society for Mathe matical Statistics and Probability. This international meeting was planned to make a state of the art for the area of semi-Markov theory and its applications, to bring together researchers in this field and to create a platform for open and thorough discussion. Main themes of the Symposium are the first ten sections of this book. The last section presented here gives an exhaustive biblio graphy on semi-Markov processes for the last ten years. Papers selected for this book are all invited papers and in addition some contributed papers retained after strong refereeing. Sections are I. Markov additive processes and regenerative systems II. Semi-Markov decision processes III. Algorithmic and computer-oriented approach IV. Semi-Markov models in economy and insurance V. Semi-Markov processes and reliability theory VI. Simulation and statistics for semi-Markov processes VII. Semi-Markov processes and queueing theory VIII. Branching IX. Applications in medicine X. Applications in other fields v PREFACE XI. A second bibliography on semi-Markov processes It is interesting to quote that sections IV to X represent a good sample of the main applications of semi-Markov processes i. e. 604 pp. Englisch.

  • Shuping Chen

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0412837900 ISBN 13 : 9780412837906

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the mathematical treatment of many problems which arise in physics, economics, engineering, management, etc., the researcher frequently faces two major difficulties: infinite dimensionality and randomness of the evolution process. Infinite dimensionality occurs when the evolution in time of a process is accompanied by a space-like dependence; for example, spatial distribution of the temperature for a heat-conductor, spatial dependence of the time-varying displacement of a membrane subject to external forces, etc. Randomness is intrinsic to the mathematical formulation of many phenomena, such as fluctuation in the stock market, or noise in communication networks. Control theory of distributed parameter systems and stochastic systems focuses on physical phenomena which are governed by partial differential equations, delay-differential equations, integral differential equations, etc., and stochastic differential equations of various types. This has been a fertile field of research with over 40 years of history, which continues to be very active under the thrust of new emerging applications. Among the subjects covered are: Control of distributed parameter systems; Stochastic control; Applications in finance/insurance/manufacturing; Adapted control; Numerical approximation . It is essential reading for applied mathematicians, control theorists, economic/financial analysts and engineers. 348 pp. Englisch.

  • Raffi Fass

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306461021 ISBN 13 : 9780306461026

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Pollution of the environment with organic compounds, mostly due to industrial ac tivities, has become a major environmental issue. The situation is getting worse due to the continued release of large amounts of chemicals and the broadening of the spectrum of xenobiotics that to which the biosphere is exposed to. The field of biodegradation and bioremediation has experienced a dynamic and in tense period of development during the last few years, encompassing all its different disci plines: Isolation and characterization of new microorganisms with novel catabolic activities, understanding the specific enzymatic mechanisms underlying biodegradation, rational design of genetically engineered degrading microorganisms, and studying the in teraction of the degrading organism with biotic and abiotic components within the envi ronment to allow development of efficient bioremediation processes. nd This book, devoted to the proceedings of the 42 OHOLO Conference on 'Novel Approaches for Bioremediation of Organic Pollution' which was held in Eilat, Israel, in May 1998, obviously does not cover the full range of bioremediation research. However, an attempt has been made to address the major issues in bioremediation of organic pollu tion. The four sessions of the conference covered a wide spectrum of topics, from the lab research-characterization of enzymes and pathways, genetic design of degradative mi croorganisms, to the field application issues-bioaccessibility, bioavailability, process de velopment and field studies. 332 pp. Englisch.

  • Vaughn Betz

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384601 ISBN 13 : 9780792384601

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since their introduction in 1984, Field-Programmable Gate Arrays (FPGAs) have become one of the most popular implementation media for digital circuits and have grown into a $2 billion per year industry. As process geometries have shrunk into the deep-submicron region, the logic capacity of FPGAs has greatly increased, making FPGAs a viable implementation alternative for larger and larger designs. To make the best use of these new deep-submicron processes, one must re-design one's FPGAs and Computer- Aided Design (CAD) tools. Architecture and CAD for Deep-Submicron FPGAs addresses several key issues in the design of high-performance FPGA architectures and CAD tools, with particular emphasis on issues that are important for FPGAs implemented in deep-submicron processes. Three factors combine to determine the performance of an FPGA: the quality of the CAD tools used to map circuits into the FPGA, the quality of the FPGA architecture, and the electrical (i.e. transistor-level) design of the FPGA. Architecture and CAD for Deep-Submicron FPGAs examines all three of these issues in concert. In order to investigate the quality of different FPGA architectures, one needs CAD tools capable of automatically implementing circuits in each FPGA architecture of interest. Once a circuit has been implemented in an FPGA architecture, one next needs accurate area and delay models to evaluate the quality (speed achieved, area required) of the circuit implementation in the FPGA architecture under test. This book therefore has three major foci: the development of a high-quality and highly flexible CAD infrastructure, the creation of accurate area and delay models for FPGAs, and the study of several important FPGA architectural issues. Architecture and CAD for Deep-Submicron FPGAs is an essential reference for researchers, professionals and students interested in FPGAs. 264 pp. Englisch.

  • K. L. Gupta

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792384040 ISBN 13 : 9780792384045

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Foreign aid has been an area of active scholarly investigation since the end of the Second World War, but particularly since the early 1950s when a large number of the erstwhile colonies became independent. Few areas of public policy involving the developed and developing countries have aroused more passion and ideological debate than foreign aid. In spite of the massive amount of research in the field, there is still not enough work in two areas: the first involves the mechanisms through which aid influences the economies of the donor and the recipient countries; and the second, country-specific assessments of the effectiveness of foreign aid. Foreign Aid: New Perspectives is aimed at making a contribution in these two areas. The contents of this volume are divided into four parts. Part I deals with some theoretical aspects of foreign aid, while the second part analyzes some general policy aspects. Part III turns to the donor experience and includes one paper on the Danish experience. The last part considers the recipient experience and consists of five case studies. 308 pp. Englisch.

  • Yigal H. Ehrlich

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306460408 ISBN 13 : 9780306460401

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 234,33

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications. 242 pp. Englisch.

  • Nydia G. Testa

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0306459620 ISBN 13 : 9780306459627

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 255,73

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express ing adenosine deaminase (the defective enzyme in patients with this disorder). The partial success of this treatment was perhaps responsible for undue optimism among those proposing other gene therapy treatments within the hematopoietic system, and it has since become clear that there are a number of technical and biological difficulties to overcome before hematopoietic gene therapy becomes a mainstream therapeutic strategy. The chapters in this book evaluate the need for gene therapy in the hematopoietic system, discuss how efficient gene transfer and expression can be achieved in the target cells, highlight areas of difficulty to be addressed, and examine a number of potential applications of the gene therapy approach. The book begins with a chapter by Testa and colleagues, discussing the various sources of hematopoietic cells for both transplantation and gene therapy. 404 pp. Englisch.

  • W. S. Chen

    Edité par Springer US Mrz 1999, 1999

    ISBN 10 : 0792356349 ISBN 13 : 9780792356349

    Langue: anglais

    Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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    EUR 298,53

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    Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Lognormal distributions are one of the most commonly studied models in the sta tistical literature while being most frequently used in the applied literature. The lognormal distributions have been used in problems arising from such diverse fields as hydrology, biology, communication engineering, environmental science, reliability, agriculture, medical science, mechanical engineering, material science, and pharma cology. Though the lognormal distributions have been around from the beginning of this century (see Chapter 1), much of the work concerning inferential methods for the parameters of lognormal distributions has been done in the recent past. Most of these methods of inference, particUlarly those based on censored samples, involve extensive use of numerical methods to solve some nonlinear equations. Order statistics and their moments have been discussed quite extensively in the literature for many distributions. It is very well known that the moments of order statistics can be derived explicitly only in the case of a few distributions such as exponential, uniform, power function, Pareto, and logistic. In most other cases in cluding the lognormal case, they have to be numerically determined. The moments of order statistics from a specific lognormal distribution have been tabulated ear lier. However, the moments of order statistics from general lognormal distributions have not been discussed in the statistical literature until now primarily due to the extreme computational complexity in their numerical determination. 884 pp. Englisch.