springer us springer new york jul 1994 (7 résultats)

Taschenbuch. Etat : Neu. Neuware -The mathematical theory of games has as its purpose the analysis of a wide range of competitive situations. These include most of the recreations which people usually call 'games' such as chess, poker, bridge, backgam mon, baseball, and so forth, but also contests between companies, military forces, and nations. For the purposes of developing the theory, all these competitive situations are called games. The analysis of games has two goals. First, there is the descriptive goal of understanding why the parties ('players') in competitive situations behave as they do. The second is the more practical goal of being able to advise the players of the game as to the best way to play. The first goal is especially relevant when the game is on a large scale, has many players, and has complicated rules. The economy and international politics are good examples. In the ideal, the pursuit of the second goal would allow us to describe to each player a strategy which guarantees that he or she does as well as possible. As we shall see, this goal is too ambitious. In many games, the phrase 'as well as possible' is hard to define. In other games, it can be defined and there is a clear-cut 'solution' (that is, best way of playing).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Probabilistic models of technical systems are studied here whose finite state space is partitioned into two or more subsets. The systems considered are such that each of those subsets of the state space will correspond to a certain performance level of the system. The crudest approach differentiates between 'working' and 'failed' system states only. Another, more sophisticated, approach will differentiate between the various levels of redundancy provided by the system. The dependability characteristics examined here are random variables associated with the state space's partitioned structure; some typical ones are as follows ¿ The sequence of the lengths of the system's working periods; ¿ The sequences of the times spent by the system at the various performance levels; ¿ The cumulative time spent by the system in the set of working states during the first m working periods; ¿ The total cumulative 'up' time of the system until final breakdown; ¿ The number of repair events during a fmite time interval; ¿ The number of repair events until final system breakdown; ¿ Any combination of the above. These dependability characteristics will be discussed within the Markov and semi-Markov frameworks. 256 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The books in this acclaimed series provide integrated, critical surveys of topics of current interest to the pharmaceutical industry. Cellular Adhesion: Molecular Definition to Therapeutic Potential covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules. 350 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Following three printings of the First Edition (1978), the publisher has asked for a Second Edition to bring the contents up to date. In doing so the authors aim to show how the newer microscopies are related to the older types with respect to theoretical resolving power (what you pay for) and resolution (what you get). The book is an introduction to students, technicians, technologists, and scientists in biology, medicine, science, and engineering. It should be useful in academic and industrial research, consulting, and forensics; how ever, the book is not intended to be encyclopedic. The authors are greatly indebted to the College of Textiles of North Carolina State University at Raleigh for support from the administration there for typing, word processing, stationery, mailing, drafting diagrams, and general assistance. We personally thank Joann Fish for word process ing, Teresa M. Langley and Grace Parnell for typing services, Mark Bowen for drawing graphs and diagrams, Chuck Gardner for photographic ser vices, Deepak Bhattavahalli for his work with the proofs, and all the other people who have given us their assistance. The authors wish to acknowledge the many valuable suggestions given by Eugene G. Rochow and the significant editorial contributions made by Elizabeth Cook Rochow.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 480 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume focuses on recent developments in our understanding of selected adhesion processes that may offer new approaches to developing therapeutics for a variety ofdiseases. The volume first introduces the molecules involved in key adhesive processes, then describes the biological consequences of several adhe sive interactions, and closes with a description of the initial therapeutic ap proaches to antagonizing. adhesion. These papers were originally presented at the SmithKline Beecham Pharmaceuticals Seventh U. S. Research Symposium held in Philadelphia in October of 1992. ofacell to asurface. In its simplestsense, cellularadhesion is the adherence The cells of interest in the context of this volume are bacterial and mammalian, with an emphasis on leukocytes; surfaces can be other cells and tissues (such as bone), matrix proteins, or inanimate objects such as in-dwelling medical devices and catheters. Interaction between adhesion molecules usually results in a spe cific biological response. Adhesion is a form ofcellularcommunication, and represents the way a cell senses its environment through contact. Like hormones and cytokines, the sol uble mediators used by cells for communication, adhesion molecules are defined molecular entities that recognize specific receptor structures on the surface to which they adhere. Recent activity has focused on defining the structure of the individual molecules responsible for many types ofcellularadhesion. New adhe sion proteins are being cloned with the help of specific antibodies and precise functional assays.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 350 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro degenerative disorders and assessing risk factors associated with neurotoxin ex posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 372 pp. Englisch.

Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Providing fresh insights into the complex relationship between stress and mental health, internationally recognized contributors identifie emerging conceptual issues, highlight promising avenues for further study, and detail novel methodological techniques for addressing contemporary empirical problems. Specific coverage includes stressful life events, chronic strains, psychosocial resources and mediators, vulnerability to stress, and mental health outcomes-thus providing researchers with a tool to take stock of the past and future of this field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.