Advances dna sequence specific agents (33 résultats)

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Hardcover. Etat : new. Hardcover. Advances in DNA Sequence-specific Agents, Volume 4 Describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders,and more. This volume includes features such as: drug design and therapeutic applications; Nucleic acid-protein interactions; and more. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

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Hardcover. Etat : new. Hardcover. Advances in DNA Sequence-specific Agents, Volume 4 Describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders,and more. This volume includes features such as: drug design and therapeutic applications; Nucleic acid-protein interactions; and more. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.…

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition. Englisch.…

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include. Expert contributors from the Biomedical world. Emerging areas of drug design and therapeutic applications. Nucleic acid-protein interactions. Color graphics of molecular modeling analyses. New and emerging methodologies 162 pp. Englisch.…