Cell membrane role interaction (10 résultats)

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Taschenbuch. Etat : Neu. MBP Interacts with PIP2 at the Oligodendroglial Cell Membrane | The Role of Phosphoinositides in the Interaction of Myelin Basic Protein with the Oligodendroglial Cell Membrane | Schanila Nawaz | Taschenbuch | 104 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838120799 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). The association of MBP as a positively-charged protein with negatively charged membranes is crucial for myelination, but the mechanisms by which MBP associates with the myelin membrane remains elusive. Here I demonstrate that the signaling lipid PIP2 is important for the stable association of MBP with cellular membranes. This association is lost upon specific decrease of membrane charges through selective hydrolyzation of PIP2 levels or through elevated intracellular Ca2+ levels. Further experiments implicate that one putative PIP2 binding domain of MBP lies within the exon-1 encoded region. The relevance of this protein-lipid interaction was demonstrated for the corpus callosum of mice, after decreasing membrane surface charges in acute brain slices. Here, PIP2 hydrolysis led to the loss of myelin compaction. The results demonstrate that PIP2 plays an important role in MBP association to the plasma membrane. These findings provide a novel link between phosphoinositol metabolism and MBP function in oligodendrocytes in development and disease.…

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The contents of this book reflect a symposium held in honor of Professor Herman Kalckar's seventy-fifth birthday. His impact on the history of biochemistry is reflected by the diversity of the contributions of his former students and friends. Speakers came from Asia, Europe, and the United States to discuss both procaryotes and eukaryotes. The unifying theme was the cell membrane, both its organization and its function. Ektobiology, a topic that has held the attention of Professor Kalckar for many years, was clearly defined as a central topic in biology. This subject deals with the key structure whereby the cell interacts with the outside world and which, in a sense, defines the boundary between what is the cell and what is not. Topics discussed include the biogenesis of membrane proteins, sugars and lipids, the role of membrane components in osmoregula tion, and mechanisms of nutrient transport. Of great interest is the system for surface recognition evolved in vertebrates, exemplified by the HLA system of man. Neoplasia causes changes in the cell membrane that may be of significant future potential in the diagnosis and treatment of malignancies as well as in the understanding of the process of transformation. The changes in glycosphingolipids and carbohydrate antigens in relation to oncogenesis are detailed. I should like to recognize Doctors Kurt J. Isselbacher, Phillips W. Robbins, Victor Ginsburg, and Hiroshi Nikaido for their ,assistance in organizing the symposium. Ms. Jean Brumbaugh deserves special thanks for putting this book together.…