comparative qsar (14 résultats)

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Paperback. Etat : Brand New. 108 pages. 8.66x5.91x0.25 inches. In Stock.

Taschenbuch. Etat : Neu. Comparative QSAR Studies of Benzamidine Derivatives via in-silico tool | Chemoinformatics for making better decisions faster in the area of drug lead identification | Upendra Bhele | Taschenbuch | 108 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783659260469 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Etat : Neu. Prediction of Glycine/NMDA Receptor Antagonism | Comparative QSAR and Molecular Docking Simulations | Manish Sharma (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659179723 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Hardcover. Etat : Very Good Plus. Book measures 24x16.5.cm. ix, 371pp. Bound in original publishers laminated hardcover, with title lettering. Covers very lightly marked, rubbed. Binding in very good clean firm condition. Internally, pages clean throughout. A good clean copy. Size: 8vo.

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods. 108 pp. Englisch.

Etat : New. Print on Demand.

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bhele UpendraAs a Bioinformatics postgraduate(MSc, MTech), Upendra Bhele has worked on various Chemoinfomatics and Pharmacoinformatics projects. He has various research papers published under his name.Thrombosis - localized clott.

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 108 pp. Englisch.

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods.

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The book comprises detailed Comparative QSAR and Molecular Docking Simulation study on selective glycine/NMDA receptor antagonists. Multiple regression Hansch analysis was conducted on fourteen diverse series. Equations generated were internally, externally and laterally validated. They indicated the importance of lipophilic, electronic and steric parameters of various substituents on quinoxalines, quinoxalin-4-ones and quinazoline-2-carboxylates. Comparison among equations with scaled CMR parameter indicated involvement of unique dual allosteric (normal and inverse) effects. Such allosterism in glycine/NMDA receptor has not been reported before. Inversion point in both relationships was amazingly 10. Accuracy in prediction of biological activity of compounds with aromatic substituents in docking simulations could not be calculated irrespective of their presence in either upward or downward legs of both closed and open parabola. This is suggestive of a mechanism wherein aromatic substituents are involved in changing the shape of active site residues of the glycine subsite. Based on non-linear closed parabolic relationships, some new promising molecules were proposed.