Structure antigens (12 résultats)

Hardcover. Etat : Very Good+. No Jacket. 563pp.incl.index; HB blue w/yellow&white; some rub; PONft.endpaper; clean,tight pgs. "This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses." 128 figures & 91 tables.…

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Couverture rigide. Etat : bon. RO60067586: 1970. In-8. Relié. Bon état, Couv. convenable, Dos satisfaisant, Intérieur acceptable. 412 pages. Illustré de schémas et photos en noir et blanc dans le texte. . . . Classification Dewey : 420-Langue anglaise. Anglo-saxon.

Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.…

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in 'immune surveillance' against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.…