Langue: anglais
Edité par Academic Press Inc 2014-01-29, 2014
ISBN 10 : 0124186750 ISBN 13 : 9780124186750
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Ajouter au panierHardcover. Etat : New.
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Ajouter au panierHardcover. Etat : Brand New. 1st edition. 513 pages. 9.50x8.00x1.00 inches. In Stock.
Langue: anglais
Edité par Elsevier Science & Technology, 2013
ISBN 10 : 0124186750 ISBN 13 : 9780124186750
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Ajouter au panierEtat : new. Questo è un articolo print on demand.
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Ajouter au panierBuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.