Copeland robert a (104 résultats)

Hardback. Etat : Very Good. This title offers vital information for discovering and optimizing new drugs. 'Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors' - Paul S. Anderson, PhD. This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, "Evaluation of Enzyme Inhibitors in Drug Discovery" focuses on the questions that they need to address: what opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism; how are inhibitors evaluated for potency, selectivity, and mode of action; what are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo; and, what information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization. Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.…

Etat : very_good.

Etat : Good. . . All orders guaranteed and ship within 24 hours. Before placing your order for please contact us for confirmation on the book's binding. Check out our other listings to add to your order for discounted shipping.

Etat : very_good. Gently read. May have name of previous ownership, or ex-library edition. Binding tight; spine straight and smooth, with no creasing; covers clean and crisp. Minimal signs of handling or shelving. 100% GUARANTEE! Shipped with delivery confirmation, if you're not satisfied with purchase please return item! Ships USPS Media Mail.…

Etat : very_good. Fast Free Shipping â" Very Good condition book with a firm cover and clean pages. Shows normal use and some light wear or limited notes markings. A solid, nice copy to enjoy.

Hardback. Etat : Very Good. This title offers vital information for discovering and optimizing new drugs. 'Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors' - Paul S. Anderson, PhD. This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, "Evaluation of Enzyme Inhibitors in Drug Discovery" focuses on the questions that they need to address: what opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism; how are inhibitors evaluated for potency, selectivity, and mode of action; what are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo; and, what information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization. Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.…

Mass Market Paperback. Etat : Good to Very Good-. First Edition. 1st printing, Sept. 1980. Cover art by is uncredited [Paul Alexander]. Paperback original. Includes "The Last Days of (Parallel?) Earth" by Robert Sheckley; "The Day After the End of the World" by Harry Harrison; "A Very Good Year, Fire And/Or Ice, Exeunt Omnes" by Roger Zelazny; "Sungrab" by William F. Nolan; "Where Are You Now, Eric Scorbic?" by K. Copeland Shea; "Bud" by Ian Watson; "The Making of Revelation" by Philip Jose Farmer; "Rebecca Rubinstein's Seventeeth Birthday" by Simon Gandolfi; "The Revelation" by Thomas M. Disch; "Nirvana Is a Nowhere Place" by Joel Schulman; "Heir" by J. A. Lawrence; "The Kingdom of O'Ryan" by Bob Shaw; "Just Another End of the World" by Maxim Jakubowski. Scarred at upper rear spine corner; edge and corner bumps and wear; bumps and dings; light tanning. Book. …

Hardcover. Etat : Acceptable. Connecting readers with great books since 1972. Used textbooks may not include companion materials such as access codes, etc. May have condition issues including wear and notes/highlighting. We ship orders daily and Customer Service is our top priority.

Etat : Good. Former library copy. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Includes library markings. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

Etat : Good. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

Etat : Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.…

Etat : New. In English. Kaufenberg, Mr Hans A (illustrateur).

Etat : Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.…

Etat : Fair. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,800grams, ISBN:9780471359296.…

Etat : Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition, suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,600grams, ISBN:9780471686965. …

hardcover. Etat : Good. Please Note: Book has different front cover than stock photo shown. Published is Chapman and Hall. Book has hardcovers with spiral binding. No DJ. Includes separate page of errata for book. Minimal to moderate highlighting and underlining in first half of book. Book shows common (average) signs of wear and use. Binding is still tight. Covers are intact but may be repaired. We have 75,000 books to choose from -- Ship within 24 hours -- Satisfaction Guaranteed.…

Etat : New. Satisfaction Guaranteed or your money back.

PAP. Etat : New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Kaufenberg, Mr Hans A (illustrateur).

Etat : good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present.

XVII/271 S./pp., Originalpappband (publisher's cardboard covers), Bibliotheksexemplar von guter Erhaltung / fine exlibrary, keine Unterstreichungen oder Anmerkungen/no underlinings or remarks, Sprache: englisch.

Hardcover. Etat : Very Good. Prompt Shipment, shipped in Boxes, Tracking PROVIDEDVery good.

Etat : NEW.

Etat : New. In English.

Hardcover. 306 p. In good condition. The pages are clean and free from markings. Shows slight signs of storage and wear. A withdrawn library copy with the relevant markings. Otherwise, a decent copy. 9780471186212 Sprache: Englisch Gewicht in Gramm: 1000.

PAP. Etat : New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Kaufenberg, Mr Hans A (illustrateur).

hardcover. Etat : New. 2nd Edition. Ships in a BOX from Central Missouri! UPS shipping for most packages, (Priority Mail for AK/HI/APO/PO Boxes).

Hardcover. Etat : Fine. Etat de la jaquette : Fine. 1st Edition. 1st ed., 4th printing ; xiv, 194 p. : ill. (some col.) ; 24 cm. ISBN 9781930897083 1930897081 LCCN 2002510026 ; LC SB61 .C67 2001 Dewey 635.0922 ; off-white textured boards in pictorial dustjacket ; SIGNED by both authors on the title page ; "One spring morning a lady walking through a garden in the Midwest was fascinated by a row of handsome, vigorous hollies. They were just what she needed for her own garden, and she asked her host what they were. "Those are Nellie Stevens hollies," was the reply. She looked again and couldn't help but wonder about the name. Who in the world is Nellie Stevens, and how did her name ever become associated with this plant? She noted other intriguing names, and she asked similar questions. She saw a beautifulblue clematis and wondered if Betty Corning was still alive and what stories she had to tell.She wondered about the places and people whose names are associated with so many popular garden plants. She is not alone. If necessity is the mother of invention, curiosity is the mother of research. In many cases, we wonder not what our gardens grow, but who our gardens grow. Until now, these accounts have not been compiled and unfortunately, many of the people are disappearing, their stories with them. Now gardeners can enjoy the beauty of their plants and delight in the tales they tell." ; Contents: Anna, Illinois -- Arnold Arboretum -- Janes Bath -- Lole Benedict -- ray Bracken -- Luther Burbank -- Molly Bush -- Cedar lane Farm -- John Champneys, Phillippe Noisette -- Corbett, maryland -- Betty Corning -- John Creech -- Roy Davidson -- Vince and Barbara Dooley -- Eco-Gardens -- Katie Ferguson -- Henry and Sally Fuller -- Fred Galle -- Gardenview Horticultural park -- Azilda Gerbing -- Goodness Grows -- Kim Hawks -- mary Gibson Henry -- Poly Hill -- Andre Iseli -- Tina James -- Joseph Kassab -- Hella Lacy -- Michael Lindsey -- Carol Mackie -- Frank N Meyer -- Montrose Nursery -- David Mooberry -- Mt. Airy Arboretum -- Jane Platt -- Saul Nurseries -- Shadow Nursery -- Betty Sheffield -- Nellie R Stevens -- Helene Strybing -- Sunny Border Nurseries -- George L Taber Sr -- Claudia Wannamaker -- Wave Hill -- Francis Williams ; FINE/FINE. Signed by Author(s). Book.…

hardcover. Etat : Like New. 2nd Edition. Ships in a BOX from Central Missouri! Like Brand NEW. No tears, highlighting or writing because it's never been used! May have minor shelf wear. UPS shipping for most packages, (Priority Mail for AK/HI/APO/PO Boxes).

Etat : New. Print on Demand.

Hardcover. Etat : Gut. 306 S. Ehem. Bibliotheksexemplar mit Signatur und Stempel. GUTER Zustand, ein paar Gebrauchsspuren. Ex-library with stamp and library-signature. GOOD condition, some traces of use. N06967 9781560819035 Sprache: Englisch Gewicht in Gramm: 700.