npg (129 résultats)

Paperback. Etat : Very Good. The book has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.

Paper Cover. Etat : Near Fine. with 64pp b&w plates.

VG, unmarked 9 1/4" x 11 1/4" Hardback; DJ-VG. [Photographs throughout] viii + 111 pp.

Signed, inscribed on title-page by co-author Judd. Brief biography and portrait of each poet. -- Hardcover, 63 pages. Condition: very good (light corner bumps; no jacket). ISBN 1855142031.

Paperback. Etat : Good. Illustrated. Virginia Woolf: Art, Life and Vision.

No Binding. Etat : Very Good. Yep. we've all had beach trips like this one. A Continental postcard of the 1910s or thereabouts, with "Rain, Rain, Go Away" lines in three different languages on the back; never mailed and in nice shape.

14,0 x 9,0 cm. Wohlfahrts-Postkarte. Die Portokosten betragen im Inland 1,00 Euro.

Etat : Good / Bien. London: NPG, cop. 1999.- 64 p.: ilus.; 8º menor.- (Character Sketches). Book in english LITERATURA Y ESTUDIOS LITERARIOS EXTRANJEROS DE LOS SIGLOS XVI-XXI.

Hardcover. Etat : Very Good. Etat de la jaquette : Very Good. inscribed by previous owner. illustrated. HEAVY BOOK.

Etat : Good.

24Mo CD. Etat : Very Good. Etat de la jaquette : Very Good. 2-CD set in bifold sleeve. Discs are clean, any incidental surface marks do not affect play.

Etat : Good. Light scratches/marks to cover & fading/scuffs around edges. Light tanning at page edges. Content very good.

First Edition. Fine cloth copy in an equally fine dust-wrapper. Particularly and surprisingly well-preserved; tight, bright, clean and especially sharp-cornered. Literally as new, still in the publisher's original shrink wrap. Physical description; 176 p. : ill. (chiefly col.), ports. ; 28 cm. SummarySynopsis: Hundreds of painted and photographic images exist of Queen Elizabeth II. Throughout her reign, she has inspired photographers and painters not only to embrace tradition but also to extend the genre of royal portraiture. To coincide with her Diamond Jubilee, this book presents portraits and images by artists including Dorothy Wilding, Cecil Beaton, Pietro Annigoni, Gerhard Richter, Patrick Lichfield, Andy Warhol, Lucian Freud, Gilbert & George, Hiroshi Sugimoto and Annie Leibovitz, that collectively chart the changing portrayal of Queen Elizabeth II, and the different ways in which her image has been appropriated and manipulated by artists as well as the mass-media. Over the last sixty years, the Queen's image has provided a fruitful and evocative area for investigation by a range of contemporary artists. Author Paul Moorhouse explores the complex evolution of these representations. Beginning with formal royal portraits, he probes the dialogue between traditional portraiture and a progressive informality in the mass-media. The author shows how this interaction has produced a new iconography that has profoundly extended the idea of the royal portrait and influenced the modern perception of monarchy. The author demonstrates that the broad range of artworks illustrated in the book provide a fascinating lens through which her reign may be viewed, evoking a wider artistic, social and historical context. The result is an inspirational book that sheds new light on the changing face of royal portraiture. Subjects; Windsor, House of. Elizabeth II, Queen of Great Britain 1926- Portraits Exhibitions. 4 Kg.

Paper covers. Etat : Fine. No Jacket. 1st edition. Scarcely used. Weight: 1.0 Language: English.

Paper covers. Etat : Good. No Jacket. 1st edition. Cover a bit soiled, no inscriptions. Weight: 1 Language: English.

Encuadernación de tapa dura. Etat : Muy bien. X2110J06516. 156 g. 66 pp. Estado, muy bien. English. Filología, biografía. With 37 illustrations, 22 in colour.

Medical research: Missing patients Effective clinical studies must consider all ethnicities ? exclusion can endanger populations, says Esteban G. Burchard. Developing world: Discuss inequality Confront economic differences to strengthen global research, urge P. Wenzel Geissler and Ferdinand Okwaro. Mental health: Tailor informed-consent processes The first step in studying mental-health interventions across cultures is to adjust procedures to participants' needs, says Mónica Ruiz-Casares. Collaboration: Strength in diversity Richard B. Freeman and Wei Huang reflect on a link between a team's ethnic mix and highly cited papers. Genetics: Under the skin Nathaniel Comfort wonders at the enduring trend of misrepresenting race. Review of A Troublesome Inheritance: Genes, Race and Human History, Race Unmasked: Biology and Race in the 20th Century & The Myth of Race: The Troubling Persistence of an Unscientific Idea Nicholas Wade, Michael Yudell & Robert Wald Sussman Physics: In thrall to uncertainty A history of how quantum theory has permeated Western culture refreshes Jim Baggott. Review of The Quantum Moment: How Planck, Bohr, Einstein, and Heisenberg Taught Us to Love Uncertainty Robert P. Crease & Alfred Scharff Goldhaber New in paperback Linguistics: The write stuff Steven Pinker's provocative treatise on language use and abuse would benefit from more data, finds Paul Raeburn. Review of The Sense of Style: The Thinking Person's Guide to Writing in the 21st Century Steven Pinker Evolution: Tribes like us Tim Lenton is intrigued by E. O. Wilson's sweeping perspective on humanity's past ? and possible futures. Review of The Meaning of Human Existence Edward O. Wilson Climate policy: A societal sea change Nico Stehr ponders Naomi Klein's call for strategic mass action on climate change. Review of This Changes Everything: Capitalism vs the Climate Naomi Klein Internet: Technology and its discontents Jaron Lanier surveys four studies probing the vexed nexus of mind and digisphere. Review of Mind Change: How Digital Technologies Are Leaving Their Mark on Our Brains, The Organized Mind: Thinking Straight in the Age of Information Overload, The Impulse Society: What's Wrong With Getting What We Want? & The Glass Cage: Automation and Us Susan Greenfield, Daniel J. Levitin, Paul Roberts & Nicholas Carr When disease strikes from nowhere When healthy parents have a child with a genetic disorder, the cause is sometimes a new mutation. Tools are emerging to meet the challenge of finding such changes. Insight: Exoplanets Exoplanets Leslie Sage Doppler spectroscopy as a path to the detection of Earth-like planets Michel Mayor, Christophe Lovis & Nuno C. Santos See also Insight by Lissauer et al. See also Insight by Pepe et al. Advances in exoplanet science from Kepler Jack J. Lissauer, Rebekah I. Dawson & Scott Tremaine Highlights in the study of exoplanet atmospheres Adam S. Burrows The role of space telescopes in the characterization of transiting exoplanets Artie P. Hatzes See also Insight by Lissauer et al. Instrumentation for the detection and characterization of exoplanets Francesco Pepe, David Ehrenreich & Michael R. Meyer See also Insight by Mayor et al. GATM locus does not replicate in rhabdomyolysis study James S. Floyd, Joshua C. Bis, Jennifer A. Brody, Susan R. Heckbert, Kenneth Rice + et al. Mangravite et al. reply Lara M. Mangravite, Barbara E. Engelhardt, Matthew Stephens & Ronald M. Krauss News & Views Top Evolutionary biology: Radiating genomes Chris D. Jiggins See also Article by Brawand et al. Condensed-matter physics: Catching relativistic electrons Zhihuai Zhu & Jennifer E. Hoffman Animal behaviour: The evolutionary roots of lethal conflict Joan B. Silk See also Letter by Wilson et al. Astrophysics: Giant black hole in a stripped galaxy Amy E. Reines See also Letter by Seth et al. 50 & 100 Years Ago Neuroscience: Shedding light on a change of mind Tomonori Takeuchi & Richard G. M. Morris See also Letter by Redondo et al. Organic chemistry: Reactivity tamed one bond at a time Matthew T. Villaume & Phil S. Baran See also Article by Meng et al. Articles Top Multifunctional organoboron compounds for scalable natural product synthesis Fanke Meng, Kevin P. McGrath & Amir H. Hoveyda A catalytic process is reported that begins with a highly selective copper?boron addition to a monosubstituted allene, and in which the resulting boron-substituted organocopper intermediate then participates in a chemoselective, site-selective and enantioselective allylic substitution; this approach is used in the enantioselective synthesis of gram quantities of two natural products. See also News & Views by Villaume & Baran The genomic substrate for adaptive radiation in African cichlid fishOpen David Brawand, Catherine E. Wagner, Yang I. Li, Milan Malinsky, Irene Keller + et al. Genomes and transcriptomes of five distinct lineages of African cichlids, a textbook example of adaptive radiation, have been sequenced and analysed to reveal that many types of molecular changes contributed to rapid evolution, and that standing variation accumulated during periods of relaxed selection may have primed subsequent diversification. See also News & Views by Jiggins Proteogenomic characterization of human colon and rectal cancer Bing Zhang, Jing Wang, Xiaojing Wang, Jing Zhu, Qi Liu + et al. Proteome analysis of The Cancer Genome Atlas (TCGA) colorectal cancer specimens reveals that DNA- or RNA-level measurements cannot reliably predict protein abundance, colorectal tumours can be separated into distinct proteotypes, and that copy number alterations drive mRNA abundance changes but few extend to protein-level changes. Molecular architecture and mechanism of the anaphase-promoting complex Leifu Chang, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin & David Barford The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the compl.

Policy: Bring sustainable energy to the developing world Investment and policies must support cheap, clean energy technologies to cut both poverty and climate change, say Reid Detchon and Richenda Van Leeuwen. Publishing: Credit where credit is due Liz Allen, Amy Brand, Jo Scott, Micah Altman and Marjorie Hlava are trialling digital taxonomies to help researchers to identify their contributions to collaborative projects. Astronomy: Art of the eclipse As the next solar eclipse approaches, Jay M. Pasachoff and Roberta J. M. Olson ponder how artists from the early Renaissance onwards have interpreted the phenomenon. Geology: Parsing eruptions Ted Nield weighs up histories of two momentous volcanic events in Iceland and Indonesia. Review of Island on Fire: The Extraordinary Story of Laki: The Volcano That Turned Eighteenth-Century Europe Dark Tambora: The Eruption That Changed the World Alexandra Witze, Jeff Kanipe & Gillen D'Arcy Wood Animal behaviour: Nomads of necessity Joel Greenberg casts an ornithologist's eye on a wide-ranging reading of animal migration. Review of The Homing Instinct: Meaning and Mystery in Animal Migration Bernd Heinrich Obesity Tony Scully Society at large Tony Scully Cell physiology: The changing colour of fat Brian Owens Treatment: Marginal gains Emily Anthes Perspective: Obesity is not a disease D. L. Katz Heritability: The family roots of obesity Cassandra Willyard Microbiome: A complicated relationship status Sarah Deweerdt Neuroscience: Dissecting appetite Bijal P. Trivedi Perspective: Tricks of the trade Stephen J. Simpson & David Raubenheimer Evolutionary biology: Dating chimpanzees Michael Haslam Genetics: Up and down in Down's syndrome Benjamin D. Pope & David M. Gilbert See also Article by Letourneau et al. Organic chemistry: Catalysis marches on James P. Morken See also Article by Mei et al. Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía See also Letter by Prindle et al. Thermoelectricity: The ugly duckling Joseph P. Heremans See also Letter by Zhao et al. Review Top The ensemble nature of allostery Hesam N. Motlagh, James O. Wrabl, Jing Li & Vincent J. Hilser Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another, often distal, functional site, allowing for the regulation of activity; here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed, and a framework to unify the description of allosteric mechanisms for different systems is proposed. Articles Top Enantioselective construction of remote quaternary stereocentres Tian-Sheng Mei, Harshkumar H. Patel & Matthew S. Sigman A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group. See also News & Views by Morken Domains of genome-wide gene expression dysregulation in Down?s syndrome Audrey Letourneau, Federico A. Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez + et al. By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21, this paper finds that differential expression between the twins is organized in domains along all chromosomes; these gene expression dysregulation domains are conserved in the mouse model of Down?s syndrome and correlate with the lamina-associated domains and replication domains. See also News & Views by Pope & Gilbert Brainstem nucleus MdV mediates skilled forelimb motor tasks Maria Soledad Esposito, Paolo Capelli & Silvia Arber The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements; in particular they discover that the medullary reticular formation ventral part (MdV) is functionally specialized for skilled forelimb motor control. Skilled reaching relies on a V2a propriospinal internal copy circuit Eiman Azim, Juan Jiang, Bror Alstermark & Thomas M. Jessell Cervical propriospinal neurons (PNs) form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals; their ablation in mice impairs reaching movements selectively, and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement. Letters Top Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars Heather B. Franz, Sang-Tae Kim, James Farquhar, James M. D. Day, Rita C. Economos + et al. Isotopic analyses of 40 Martian meteorites indicate that assimilation of sulphur into Martian magmas was a common occurrence throughout much of the planet?s history and that the atmospheric imprint of photochemical processing preserved in Martian meteoritic sulphide and sulphate is distinct from that observed in terrestrial analogues. Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles Ioan M. Pop, Kurtis Geerlings, Gianluigi Catelani, Robert J. Schoelkopf, Leonid I. Glazman + et al. The long-predicted suppression of quasiparticle dissipation in a Josephson junction when the phase difference across the junction is ? is inferred from a sharp maximum in the energy relaxation time of a superconducting artificial atom. Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals Li-Dong Zhao, Shih-Han Lo, Yongsheng Zhang, Hui Sun, Gangjian Tan + et al. The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity, whereas one ideally wants to raise the former while lowering the latter: a simple layered crystalline material ? SnSe ? is now reported that seems to have these qualities built in. See also News & Views by Heremans Mid-latitude interhemispheric hydrologic seesaw over the past 550,000 years Kyoung-nam Jo, Kyung Sik Woo.

Mental health: A road map for suicide research and prevention It is time for policy-makers, funders, researchers and clinicians to tackle high suicide rates, say André Aleman and Damiaan Denys. Evolutionary biology: Darwin and the women Sarah S. Richardson relishes a study of how nineteenth-century US feminists used the biologist's ideas. Review of From Eve to Evolution: Darwin, Science, and Women's Rights in Gilded Age America Kimberly A. Hamlin Information technology: Forgotten prophet of the Internet Philip Ball ponders the tale of a librarian who dreamed of networking information. Review of Cataloging the World: Paul Otlet and the Birth of the Information Age Alex Wright European pollution: Investigate smog to inform policy Paul S. Monks Databases: Soil observatory lets researchers dig deep Russell Lawley, Bridget A. Emmett & David A. Robinson Health care: Strict vaccine quality control in China Zhenglun Liang, Qunying Mao & Junzhi Wang Political ecology: Rethink Campania's toxic-waste scandal Giacomo D'Alisa, Marco Armiero & Salvatore Paolo De Rosa Technology: Internal factors drive Chinese patent surge Ching-Yan Wu, Mei-Chih Hu & John A. Mathews Epigenetics: Keeping one's sex Douglas L. Chalker See also Article by Singh et al. Astrophysics: Windy stars that go with a bang John J. Eldridge See also Letter by Gal-Yam et al. Physiology: Double function at the blood?brain barrier Christer Betsholtz See also Letter by Nguyen et al. See also Letter by Ben-Zvi et al. Materials chemistry: Selectivity from flexibility Ryotaro Matsuda Cancer: Darwinian tumour suppression Eduardo Moreno See also Article by Martins et al. Earth science: Fertile fields for seismicity Paul Lundgren See also Letter by Amos et al. Articles Top Genome-defence small RNAs exapted for epigenetic mating-type inheritance Deepankar Pratap Singh, Baptiste Saudemont, Gérard Guglielmi, Olivier Arnaiz, Jean-François Goût + et al. The molecular basis for mating-type determination in the ciliate Paramecium has been elucidated, revealing a novel function for a class of small RNAs ? these scnRNAs are typically involved in reprogramming the Paramecium genome during sexual reproduction by recognizing and excising transposable elements, but they are now found to be co-opted to switch off expression of the newly identified mating-type gene mtA by excising its promoter, and to mediate epigenetic inheritance of mating types across sexual generations. See also News & Views by Chalker Amygdala interneuron subtypes control fear learning through disinhibition Steffen B. E. Wolff, Jan Gründemann, Philip Tovote, Sabine Krabbe, Gilad A. Jacobson + et al. Plasticity within neuronal microcircuits is believed to be the substrate of learning, and this study identifies two distinct disinhibitory mechanisms involving interactions between PV+ and SOM+ interneurons that dynamically regulate principal neuron activity in the amygdala and thereby control auditory fear learning. Contrasting forms of cocaine-evoked plasticity control components of relapse Vincent Pascoli, Jean Terrier, Julie Espallergues, Emmanuel Valjent, Eoin Cornelius O?Connor + et al. Information integration in the nucleus accumbens is commandeered by cocaine at discrete synapses to allow relapse. Cell competition is a tumour suppressor mechanism in the thymus Vera C. Martins, Katrin Busch, Dilafruz Juraeva, Carmen Blum, Carolin Ludwig + et al. T cells develop from thymic precursor cells that are constantly replaced with newly arriving bone marrow progenitor cells, and the ?old? and ?new? cells are shown here to compete; in the absence of cell competition, when the influx of new bone marrow progenitor cells is blocked, the old cells acquire the ability to self-renew and eventually become transformed, leading to the development of a form of leukaemia. See also News & Views by Moreno Letters Top A Wolf?Rayet-like progenitor of SN 2013cu from spectral observations of a stellar wind Avishay Gal-Yam, I. Arcavi, E. O. Ofek, S. Ben-Ami, S. B. Cenko + et al. The detection of strong emission lines in an early-time spectrum of type IIb supernova SN 2013cu reveals Wolf?Rayet-like wind signatures, suggesting that the supernova?s progenitor may have been a Wolf?Rayet star with a wind dominated by helium and nitrogen, with traces of hydrogen. See also News & Views by Eldridge Practical quantum key distribution protocol without monitoring signal disturbance Toshihiko Sasaki, Yoshihisa Yamamoto & Masato Koashi Conventional quantum cryptography relies on monitoring signal disturbance to make sure that information leakage is negligible; here a new quantum method of achieving security is described, in which little information is leaked to the eavesdropper regardless of the signal disturbance. Future increases in Arctic precipitation linked to local evaporation and sea-ice retreat R. Bintanja & F. M. Selten Precipitation is expected to increase far more over the twenty-first century in the Arctic than the global average; climate models show that this is driven mainly by increased local evaporation and sea-ice retreat, rather than by increased moisture transport from lower latitudes. Uplift and seismicity driven by groundwater depletion in central California Colin B. Amos, Pascal Audet, William C. Hammond, Roland Bürgmann, Ingrid A. Johanson + et al. Human-caused groundwater depletion in California?s San Joaquin Valley contributes to uplift of the surrounding mountains and may affect the stability of the San Andreas Fault. See also News & Views by Lundgren High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells Yuexin Zhou, Shiyou Zhu, Changzu Cai, Pengfei Yuan, Chunmei Li + et al. This study describes the construction of a focused CRISPR/Cas-based lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis. Copper is required for oncogenic BRAF signalling and tumorigenesis Donita C. Brady, M.

Climate science: Understand Arctic methane variability Expand ground monitoring of polar sources of this greenhouse gas to find out how climate change will influence its release, says Torben R. Christensen. Policy: NIH to balance sex in cell and animal studies Janine A. Clayton and Francis S. Collins unveil policies to ensure that preclinical research funded by the US National Institutes of Health considers females and males. Sociobiology: The distributed brain Herbert Gintis salutes the follow-up to a study on sociality and hominin brain size. Review of Thinking Big: How the Evolution of Social Life Shaped the Human Mind Clive Gamble, John Gowlett & Robin Dunbar Books in brief Chemistry: Intoxicating science Jamie Goode drinks in two views of that most venerable and destructive drug ? alcohol. Review of Proof: The Science of Booze & The Drunken Monkey: Why We Drink and Abuse Alcohol Adam Rogers & Robert Dudley Development: Dammed dreams Monya Baker is swept along by a documentary film tracing humanity's complex relationship with water. Review of Watermark Edward Burtynsky & Jennifer Baichwal Climate science: Shifting storms Hamish Ramsay See also Letter by Kossin et al. Synthetic biology: New letters for life's alphabet Ross Thyer & Jared Ellefson See also Letter by Malyshev et al. Organic chemistry: Collaborative synthesis John L. Wood See also Article by Mercado-Marin et al. Neurobiology: To care or not to care Ivan Rodriguez See also Article by Wu et al. 50 & 100 Years Ago Sensory biology: Radio waves zap the biomagnetic compass Joseph L. Kirschvink See also Letter by Engels et al. Evolution: Geology and climate drive diversification Rosemary G. Gillespie & George K. Roderick Articles Top Total synthesis and isolation of citrinalin and cyclopiamine congeners Eduardo V. Mercado-Marin, Pablo Garcia-Reynaga, Stelamar Romminger, Eli. F. Pimenta, David K. Romney + et al. Natural products citrinalin B and cyclopiamine B, which contain basic nitrogen atoms that are susceptible to oxidation during synthesis, can be synthesized by the selective introduction and removal of functional groups. See also News & Views by Wood Galanin neurons in the medial preoptic area govern parental behaviour Zheng Wu, Anita E. Autry, Joseph F. Bergan, Mitsuko Watabe-Uchida & Catherine G. Dulac Sexual experience brings radical changes in how male mice behave with pups?virgin males attack them whereas mature fathers display parental care; here the authors identify a subset of hypothalamic neurons whose ablation leads to parental deficits in both males and females, and whose activation in virgin males suppresses aggression and induces pup grooming. See also News & Views by Rodriguez Space?time wiring specificity supports direction selectivity in the retina Jinseop S. Kim, Matthew J. Greene, Aleksandar Zlateski, Kisuk Lee, Mark Richardson + et al. Motion detection by the retina is thought to rely largely on the biophysics of starburst amacrine cell dendrites; here machine learning is used with gamified crowdsourcing to draw the wiring diagram involving amacrine and bipolar cells to identify a plausible circuit mechanism for direction selectivity; the model suggests similarities between mammalian and insect vision. c-kit+ cells minimally contribute cardiomyocytes to the heart Jop H. van Berlo, Onur Kanisicak, Marjorie Maillet, Ronald J. Vagnozzi, Jason Karch + et al. Whether or not endogenous c-kit+ cells residing within the heart contribute cardiomyocytes during physiological ageing or after injury remains unknown; here, using an inducible lineage tracing system, the c-kit+ lineage is shown to generate cardiomyocytes at very low levels, and, by contrast, contributes substantially to cardiac endothelial cell generation. Letters Top Cepheid variables in the flared outer disk of our galaxy Michael W. Feast, John W. Menzies, Noriyuki Matsunaga & Patricia A. Whitelock Five classical Cepheids have been detected in the outer parts of our Galaxy beyond the Galactic bulge; they are probably associated with the gas in the flared disk and, if so, they are the first stars to be identified in the flare. Tracking excited-state charge and spin dynamics in iron coordination complexes Wenkai Zhang, Roberto Alonso-Mori, Uwe Bergmann, Christian Bressler, Matthieu Chollet + et al. Femtosecond resolution X-ray fluorescence spectroscopy is shown to track the charge and spin dynamics triggered when an iron coordination complex is excited by light, and establishes the critical role of intermediate spin states in the de-excitation process. The poleward migration of the location of tropical cyclone maximum intensity James P. Kossin, Kerry A. Emanuel & Gabriel A. Vecchi Analysis of global historical data in the Northern and Southern hemispheres reveals a statistically significant, poleward migration of 1° per decade in the average latitude at which tropical cyclones have achieved their lifetime-maximum intensity over the past 30 years. See also News & Views by Ramsay Anthropogenic electromagnetic noise disrupts magnetic compass orientation in a migratory bird Svenja Engels, Nils-Lasse Schneider, Nele Lefeldt, Christine Maira Hein, Manuela Zapka + et al. For the first time under reproducible and fully double-blinded conditions, it is shown that anthropogenic electromagnetic noise below the WHO limits affects a biological system: night-migrating birds lose the ability to use the Earth?s magnetic field for orientation when exposed to anthropogenic electromagnetic noise at strengths routinely produced by commonly used electronic devices. See also News & Views by Kirschvink Dynamics and associations of microbial community types across the human body Tao Ding & Patrick D. Schloss The microbiome composition of 300 individuals sampled over 12?18 months was partitioned into microbial community types, which could be associated with the type found at other body sites, as well as with whether individuals were breastfed as an infant, their gender and thei.

Climate policy: Streamline IPCC reports As the Intergovernmental Panel on Climate Change asks how its assessment process should evolve, Dave Griggs argues for decadal updates and eased workloads. Global warming: Improve economic models of climate change Costs of carbon emissions are being underestimated, but current estimates are still valuable for setting mitigation policy, say Richard L. Revesz and colleagues. Biotechnology: Recombinant gold Nathaniel Comfort applauds a nuanced history of genetic engineering's early years. Review of Gene Jockeys: Life Science and the Rise of Biotech Enterprise Nicolas Rasmussen Ecology: Wilson in Africa Stuart Pimm enjoys a fellow naturalist's first visit to sub-Saharan Africa, and the global lessons drawn from it. Review of A Window on Eternity: A Biologist's Walk Through Gorongosa National Park Edward O. Wilson New in paperback Highlights of this season's releases Climate Economics: A strained relationship Scott Barrett examines a study probing the nexus between climate change and energy. Review of Planetary Economics: Energy, Climate Change and the Three Domains of Sustainable Development Michael Grubb, Jean-Charles Hourcade & Karsten Neuhoff Medicine: Outside the fold Giovanna Mallucci assesses the autobiography of Stanley Prusiner, the discoverer of prions. Review of Madness and Memory: The Discovery of Prions ? A New Biological Principle of Disease Stanley B. Prusiner Drugs: Gut response Maryn McKenna finds much to digest in a warning about the demise of our bodily bacteria. Review of Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues Martin J. Blaser Education: Digital lessons learned Robert Lue enjoys a deft study of online pedagogy. Review of The War on Learning: Gaining Ground in the Digital University Elizabeth Losh Energy: The new oil era Chris Nelder relishes a lively history of fracking that delves into the complexities. Review of The Boom: How Fracking Ignited the American Energy Revolution and Changed the World Russell Gold Solar system: Cracking up on asteroids Heather A. Viles See also Letter by Delbo et al. Cancer: Damage prevention targeted Dan Dominissini & Chuan He See also Article by Gad et al. See also Article by Huber et al. Biogeoscience: Africa's greenhouse-gas budget is in the red Cheikh Mbow Metabolism: Targeting a fat-accumulation gene Charles Brenner See also Letter by Kraus et al. Quantum physics: A strong hybrid couple Luming Duan See also Letter by Reiserer et al. See also Letter by Tiecke et al. Structural biology: The purple heart of photosynthesis Richard J. Cogdell & Aleksander W. Roszak See also Article by Niwa et al. Articles Top Transcriptional landscape of the prenatal human brain Jeremy A. Miller, Song-Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng + et al. A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders. A mesoscale connectome of the mouse brain Seung Wook Oh, Julie A. Harris, Lydia Ng, Brent Winslow, Nicholas Cain + et al. In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A. Jacques + et al. In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 ? in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models. See also News & Views by Dominissini & He See also Article by Huber et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy Kilian V. M. Huber, Eidarus Salah, Branka Radic, Manuela Gridling, Jonathan M. Elkins + et al. A chemoproteomic screen is used here to identify MTH1 as the target of SCH51344, an experimental RAS-dependent cancer drug; a further search for inhibitors revealed (S)-crizotinib as a potent MTH1 antagonist, which suppresses tumour growth in animal models of colon cancer, and could be part of a new class of anticancer drugs. See also News & Views by Dominissini & He See also Article by Gad et al. Structure of the LH1?RC complex from Thermochromatium tepidum at 3.0 Å Satomi Niwa, Long-Jiang Yu, Kazuki Takeda, Yu Hirano, Tomoaki Kawakami + et al. The near-atomic-level structure of a complete bacterial light-harvesting antenna?reaction centre (LH1?RC) complex is described here; the structure reveals how energy is transferred from the LH1 to the RC in a highly efficient way and suggests how ubiquinone might cross a closed LH1 barrier. See also News & Views by Cogdell & Roszak Letters Top Thermal fatigue as the origin of regolith on small asteroids Marco Delbo, Guy Libourel, Justin Wilkerson, Naomi Murdoch, Patrick Michel + et al. Thermal fatigue resulting from diurnal temperature variations is shown to be the dominant means of rock fragmentation and, consequently, regolith formation on small asteroids. See also News & Views by Viles A quantum gate between a flying optical photon and a single trapped atom Andreas Reiserer, Norbert Kalb, Gerhard Rempe & Stephan Ritter Quantum gates ? in which stationary quantum bits are combined with ?flying? quantum bits, that is, photons ? will be essential in quantum networks; such a gate, between a laser-trapped atomic quantum bit and a single photon, is now reported. See also News & Views by.

History: A medieval multiverse Ideas in a thirteenth-century treatise on the nature of matter still resonate today, say Tom C. B. McLeish and colleagues. Policy: The art of science advice to government Peter Gluckman, New Zealand's chief science adviser, offers his ten principles for building trust, influence, engagement and independence. Books and Arts Top In retrospect: Sylva Gabriel Hemery celebrates the 350th anniversary of John Evelyn's treatise on the science and practice of forestry. Review of Sylva; Or a Discourse of Forest-Trees, and the Propagation of Timber in His Majesties Dominions John Evelyn Particle physics: Higgs on the big screen Alexandra Witze savours a behind-the-scenes look at physics's most famous arrival. Review of Particle Fever Mark Levinson Evolutionary biology: Sex, lies and butterflies David W. Loehlin & Sean B. Carroll See also Letter by Kunte et al. Astrophysics: Cosmic lens reveals spinning black hole Guido Risaliti See also Letter by Reis et al. Geology: Earth's deep water reservoir Hans Keppler See also Letter by Pearson et al. Neurodegenerative diseases: G-quadruplex poses quadruple threat J. Paul Taylor See also Article by Haeusler et al. Neuroscience: Ordered randomness in fly love songs Bence P. Ölveczky See also Letter by Coen et al. 50 & 100 Years Ago Evolutionary biology: Speciation undone Peter R. Grant & B. Rosemary Grant Articles Top Alveolar progenitor and stem cells in lung development, renewal and cancer Tushar J. Desai, Douglas G. Brownfield & Mark A. Krasnow Lung alveoli are lined by two types of alveolar epithelial cells, squamous alveolar type (AT) 1 cells that mediate gas exchange and cuboidal AT2 cells that secrete surfactant to prevent alveolar collapse during breathing; here alveolar markers, genetic lineage tracing and clonal analysis are used in mice to identify alveolar progenitor and stem cells in vivo, and to map their locations and potential during lung development, maintenance and cancer. C9orf72 nucleotide repeat structures initiate molecular cascades of disease Aaron R. Haeusler, Christopher J. Donnelly, Goran Periz, Eric A. J. Simko, Patrick G. Shaw + et al. Structurally polymorphic C9orf72 hexanucleotide repeats cause an impairment in transcriptional processivity and lead to accumulation of truncated repeat-containing transcripts that bind to specific ribonucleoproteins, such as nucleolin, in a conformation-dependent manner resulting in nucleolar stress and C9orf72-linked pathology in amyotrophic lateral sclerosis and frontotemporal dementia. See also News & Views by Taylor Proof of principle for epitope-focused vaccine design Bruno E. Correia, John T. Bates, Rebecca J. Loomis, Gretchen Baneyx, Chris Carrico + et al. Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine; artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques. Letters Top Reflection from the strong gravity regime in a lensed quasar at redshift z = 0.658 R. C. Reis, M. T. Reynolds, J. M. Miller & D. J. Walton Observations of a gravitationally lensed quasar at redshift 0.658 imply a high spin parameter, which indicates that this supermassive black hole grew by coherent accretion rather than in a chaotic manner. See also News & Views by Risaliti Interrogating selectivity in catalysis using molecular vibrations Anat Milo, Elizabeth N. Bess & Matthew S. Sigman A set of parameters based on the response of a molecule?s properties to infrared vibrations can be used to model and predict selectivity trends for molecular reactions with interlinked steric and electronic effects at positions of interest Conformation-induced remote meta-C?H activation of amines Ri-Yuan Tang, Gang Li & Jin-Quan Yu In anilines and benzylic amines, a recyclable chemical template can direct the olefination and acetoxylation of meta-C?H bonds as far as 11 bonds away from a functional group; in particular, it is able to direct the meta-selective C?H functionalization of bicyclic heterocycles via a highly strained, tricyclic-cyclophane-like palladated intermediate. Hydrous mantle transition zone indicated by ringwoodite included within diamond D. G. Pearson, F. E. Brenker, F. Nestola, J. McNeill, L. Nasdala + et al. X-ray diffraction, Raman and infrared spectroscopic evidence for the inclusion of water-rich ringwoodite in diamond from Juína, Brazil, indicates that, at least locally, the Earth?s transition zone is hydrous to about 1 weight per cent. See also News & Views by Keppler Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European Iñigo Olalde, Morten E. Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W. K. Chiang + et al. A complete pre-agricultural European human genome from a ~7,000-year-old Mesolithic skeleton suggests the existence of a common genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic, and ancestral alleles in several skin pigmentation genes suggest that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. doublesex is a mimicry supergene K. Kunte, W. Zhang, A. Tenger-Trolander, D. H. Palmer, A. Martin + et al. The phenomenon of sex-limited mimicry is phylogenetically widespread in the swallowtail butterfly genus Papilio ? now, a single gene, doublesex, is shown to control supergene mimicry, a finding that is in contrast to the long-held view that supergenes are likely to be controlled by a tightly linked cluster of loci. See also News & Views by Loehlin & Carroll Dynamic sensory cues shape song structure in Drosophila Philip Coen, Jan Clemens, Andrew J. Weinstein, Diego A. Pacheco, Yi Deng + et al. Drosophila male courtship songs were thought to have a fixed structure with song repetition variations introduced unintentionally because of neural noise; this behavioural assay and computational modelli.

Soft cover. Etat : Very Good. Very good book.300pp with colour illustrations. 0.

Etat : Used - Good. Good paperback. 4th ed. Cover a little worn. Used - Good. Good paperback.

Etat : Good. Item in good condition. Textbooks may not include supplemental items i.e. CDs, access codes etc.

Etat : good. This book is in good condition. The cover has minor creases or bends. The binding is tight and pages are intact. Some pages may have writing or highlighting.

Card Cover. Etat : Very Good. First Edition. Softcover Princes of Victorian Bohemia National Portait Gallery London95pp We carry a wide selection of titles in The Arts, Theology, History, Politics, Social and Physical Sciences. Academic and Scholarly books and Modern First Editions ,and all types of Educational Reference Literature.).

First Edition. Fine cloth copy in an equally fine dust-wrapper. Particularly and surprisingly well-preserved; tight, bright, clean and especially sharp-cornered. Literally as new, still in the publisher's original shrink wrap. Physical description; 176 p. : ill. (chiefly col.), ports. ; 28 cm. SummarySynopsis: Hundreds of painted and photographic images exist of Queen Elizabeth II. Throughout her reign, she has inspired photographers and painters not only to embrace tradition but also to extend the genre of royal portraiture. To coincide with her Diamond Jubilee, this book presents portraits and images by artists including Dorothy Wilding, Cecil Beaton, Pietro Annigoni, Gerhard Richter, Patrick Lichfield, Andy Warhol, Lucian Freud, Gilbert & George, Hiroshi Sugimoto and Annie Leibovitz, that collectively chart the changing portrayal of Queen Elizabeth II, and the different ways in which her image has been appropriated and manipulated by artists as well as the mass-media. Over the last sixty years, the Queen's image has provided a fruitful and evocative area for investigation by a range of contemporary artists. Author Paul Moorhouse explores the complex evolution of these representations. Beginning with formal royal portraits, he probes the dialogue between traditional portraiture and a progressive informality in the mass-media. The author shows how this interaction has produced a new iconography that has profoundly extended the idea of the royal portrait and influenced the modern perception of monarchy. The author demonstrates that the broad range of artworks illustrated in the book provide a fascinating lens through which her reign may be viewed, evoking a wider artistic, social and historical context. The result is an inspirational book that sheds new light on the changing face of royal portraiture. Subjects; Windsor, House of. Elizabeth II, Queen of Great Britain 1926- Portraits Exhibitions. 2 Kg.

Etat : Good. Original stapled wrappers, softcover, illustrated with numerous photographs in colour, unpaged, 4to.; Light scratching to rear cover.

Audio CD. Etat : Sehr gut. 1 CD, 11 Tracks. CD sehr gut erhalten. LÄUFT! TOP!! Sprache: Englisch Gewicht in Gramm: 550.