Springer basel birkhäuser basel jun 2012 (4 résultats)

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter. 332 pp. Englisch.…

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites ii) What determines the density and pattern of inner vation at reaching the effector iii) How do the nerves survive and maintain their position once established iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters v) What influence do nerves have on the structure, function and receptor expression of their effector cells vi) How do diseases interrupt these processes - see [1]. 424 pp. Englisch.…

Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present volume contains a collection of original research articles and expository contributions on recent developments in operator theory and its multifaceted applications. They cover a wide range of themes from the IWOTA 2010 conference held at the TU Berlin, Germany, including spectral theory, function spaces, mathematical system theory, evolution equations and semigroups, and differential and difference operators. The book encompasses new trends and various modern topics in operator theory, and serves as a useful source of information to mathematicians, scientists and engineers. 704 pp. Englisch.…

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biographie 11 2 Projektive Geometrie 31 3 Die Erfindung der Rechenmaschine 47 4 Das arithmetische Dreieck . . . . 59 5 Die Genesis der Wahrscheinlichkeitsrechnung . 77 6 Der Weg zur lnfinitesimalrechnung . . . . . 97 7 Reflexionen tiber die mathematische Methode 119 8 Physik 125 9 Der PAScALsche Kosmos 137 10 Epilog 149 11 Chronologie 152 Anmerkungen 159 163 Literatur Personentafel 167 Sachindex . 173 Bildnachweis . 176 FUR MARLIES 7 Vorwort BLAISE PASCAL ist eine faszinierende, aber schwer fassbare Person lichkeit universaler Pragung. Das geistige Vermachtnis des jugendli chen Genies erstreckt sich von der Mathematik, Physik und Philo sophie bis hin zur Literatur und Theologie. Der zweite Band der Serie Vita M athematica ist der Biogra phie und dem wissenschaftlichen Werk gewidmet, wobei hier die Mathematik im Vordergrund steht. Nach einer einfUhrenden Le bensbeschreibung werden die einzelnen Disziplinen vorgestellt, unter Einbezug gewisser allgemeiner entwicklungsgeschichtlicher Fakten. Es kommen zur Sprache: Die projektive Geometrie, die Rechenma schine, das arithmetische Dreieck (heute PAScALsches Dreieck ge nannt), die Wahrscheinlichkeitsrechnung und die Infinitesimalrech nung. Ein kurzes Kapitel ist auch der Physik gewidmet. 176 pp. Deutsch. …