Anandhakumar (53 résultats)

XV, 114 p. Softcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses. Recognizing Outstanding Ph.D. Research. Sprache: Englisch.…

Etat : New. In English.

Etat : New. In English.

hardcover. Etat : Fine.

Etat : New. Softcover reprint of the original 1st ed. 2018 edition NO-PA16APR2015-KAP.

Etat : New.

Etat : New.

Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.…

Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.…

Paperback. Etat : Brand New. reprint edition. 132 pages. 9.25x6.10x0.30 inches. In Stock.

Hardcover. Etat : Brand New. 129 pages. 9.25x6.10x0.59 inches. In Stock.

Taschenbuch. Etat : Neu. Advancing Development of Synthetic Gene Regulators | With the Power of High-Throughput Sequencing in Chemical Biology | Anandhakumar Chandran | Taschenbuch | Springer Theses | xv | Englisch | 2019 | Springer | EAN 9789811348990 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Etat : As New. Unread book in perfect condition.

Etat : New.

Etat : As New. Unread book in perfect condition.

Etat : New. 1st edition NO-PA16APR2015-KAP.

Etat : New.

HRD. Etat : New. New Book. Shipped from UK. Established seller since 2000.

Etat : New.

HRD. Etat : New. New Book. Shipped from UK. Established seller since 2000.

Etat : New.

Etat : New.

Etat : As New. Unread book in perfect condition.

Hardback. Etat : New. New copy - Usually dispatched within 4 working days.

Etat : New. In English.

Etat : New.

Etat : As New. Unread book in perfect condition.

Etat : New.

Hardback. Etat : New. This book presents a thorough examination of computational intelligence and its significant influence on solving intricate engineering challenges. It covers fundamental theories as well as advanced applications, illustrating how techniques in computational intelligence are transforming engineering practices. The book is organized into distinct sections, each concentrating on specific engineering domains in which computational intelligence assumes a critical role. The bookpresents a methodical coverage of computational intelligence principles and techniques, illustrated by examples from various engineering domainsemphasizes a problem-solving approach, demonstrating how computational intelligence can be used to tackle complex problemsoffers use cases and real-world examples to facilitate targeted learning and understanding, andincludes discussion on ethical considerations, advocating for the responsible use of technology and consideration of societal impactsThis reference book is for engineers, researchers, and scholars interested in computational intelligence techniques in engineering.…

Etat : New. Outlines the significance of phytochemicals in nanomaterial biosynthesis for sustainable applications Explores the efficiency of phytosynthesized nanomaterials in various biomedical applications, including cancer, diabetes and cardiovascul.